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Cat. No.: HY-N10898

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(-)-Dihydroguaiaretic acid

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(-)-Dihydroguaiaretic acid is a Lipoxygenase inhibitor that has antioxidant activity. (-)-Dihydroguaiaretic acid inhibits the oxidation of unsaturated fatty acids and removes free radicals. (-)-Dihydroguaiaretic acid also has anticancer activity with an IC₅₀ value of 7.49 μM (A549 cells).

For research use only. We do not sell to patients.

Purity: 98.79%
CAS No.: 124649-78-1
Formula: C₂₀H₂₆O₄
Molecular Weight:330.42

Storage:

-20°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

(-)-Dihydroguaiaretic acid Chemical Structure

CAS No.: 124649-78-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Lipoxygenase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	31.2 μM Compound: 3	Induction of early stage apoptosis in human A549 cells assessed as mitotracker dye uptake Induction of early stage apoptosis in human A549 cells assessed as mitotracker dye uptake	[PMID: 19138858]
A549	IC₅₀	7.49 μM Compound: 3	Cytotoxicity against human A549 cells after 24 hrs by propidium iodide assay Cytotoxicity against human A549 cells after 24 hrs by propidium iodide assay	[PMID: 19138858]
A549	IC₅₀	7.49 μM Compound: 3	Cytotoxicity against human A549 cells after 24 hrs by YO-PRO-1 assay Cytotoxicity against human A549 cells after 24 hrs by YO-PRO-1 assay	[PMID: 19138858]
HeLa	EC₅₀	22 μM Compound: 4	Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 48 hrs by WST-8 assay Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 48 hrs by WST-8 assay	[PMID: 28754364]
HeLa	IC₅₀	26 μM Compound: 2	Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 48 hrs by WST-8 reduction assay Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 48 hrs by WST-8 reduction assay	[PMID: 27210431]
HL-60	EC₅₀	26 μM Compound: 4	Cytotoxicity against human HL60 cells assessed as reduction in cell viability after 48 hrs by WST-8 assay Cytotoxicity against human HL60 cells assessed as reduction in cell viability after 48 hrs by WST-8 assay	[PMID: 28754364]
HL-60	IC₅₀	22 μM Compound: 2	Cytotoxicity against human HL60 cells assessed as reduction in cell viability after 48 hrs by WST-8 reduction assay Cytotoxicity against human HL60 cells assessed as reduction in cell viability after 48 hrs by WST-8 reduction assay	[PMID: 27210431]
Sf9	IC₅₀	29 μM Compound: 2	Cytotoxicity against fall armyworm Sf9 cells assessed as reduction in cell viability after 48 hrs by WST-8 reduction assay Cytotoxicity against fall armyworm Sf9 cells assessed as reduction in cell viability after 48 hrs by WST-8 reduction assay	[PMID: 27210431]

Chemical Information

CAS No. 124649-78-1
Appearance Solid
Molecular Weight 330.42
Formula C₂₀H₂₆O₄
Color White to off-white
SMILES

COC(C=C1C[C@@H](C)[C@H](C)CC2=CC(OC)=C(C=C2)O)=C(C=C1)O
Structure Classification
- Phenols
- Polyphenols
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yamauchi S, et al. Antioxidant activity of butane type lignans, secoisolariciresinol, dihydroguaiaretic acid, and 7,7'-oxodihydroguaiaretic acid. Biosci Biotechnol Biochem. 2008 Nov;72(11):2981-6. [Content Brief]

[2]. Davis R A, et al. Isolation, structure elucidation and cytotoxic evaluation of endiandrin B from the Australian rainforest plant Endiandra anthropophagorum[J]. Bioorganic & medicinal chemistry, 2009, 17(3): 1387-1392.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
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Purity & Documentation
References

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(-)-Dihydroguaiaretic acid

High-Throughput Bioactive Compound Library

All Lipoxygenase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

(-)-Dihydroguaiaretic acid Related Classifications

HY-N10898 Related Classifications