Antioxidant activity of butane type lignans, secoisolariciresinol, dihydroguaiaretic acid, and 7,7'-oxodihydroguaiaretic acid

  • Biosci Biotechnol Biochem. 2008 Nov;72(11):2981-6. doi: 10.1271/bbb.80461.
Satoshi Yamauchi  1 ,  Toshiya Masuda ,  Takuya Sugahara ,  Yuya Kawaguchi ,  Maya Ohuchi ,  Tatsushi Someya ,  Jun Akiyama ,  Shiori Tominaga ,  Manami Yamawaki ,  Taro Kishida ,  Koichi Akiyama ,  Masafumi Maruyama
Affiliations
  • 1. Faculty of Agriculture, Ehime University, Japan.
PMID: 18997397 DOI: 10.1271/bbb.80461
Abstract

The antioxidant activity of butane-type Lignans was evaluated. Secoisolariciresinol (SECO) and dihydroguaiaretic acid (DGA) showed higher radical scavenging activity than that of 7,7'-dioxodihydroguaiaretic acid (ODGA). SECO and DGA inhibited the oxidation of unsaturated fatty acid. Both enantiomers of DGA were also Lipoxygenase inhibitors, but neither enantiomer of SECO inhibited the Lipoxygenase activity.

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