2. Signaling Pathways
  3. Cell Cycle/DNA Damage
    Epigenetics
  4. Sirtuin

Sirtuin

Sirtuin

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Sirtuin (Sir2 proteins) are a class of proteins that possess either mono-ADP-ribosyltransferase, or deacylase activity, including deacetylase, desuccinylase, demalonylase, demyristoylase and depalmitoylase activity. Sirtuins regulate important biological pathways in bacteria, archaeaand eukaryotes. Sirtuins have been implicated in influencing a wide range of cellular processes like aging, transcription, apoptosis, inflammation and stress resistance, as well as energy efficiency and alertness during low-calorie situations. Sirtuins can also control circadian clocks and mitochondrial biogenesis.

Sirtuin Isoform Specific Products:

Sirtuin Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-161339
    SIRT2-IN-13
    		Inhibitor
    SIRT2-IN-13 (compound 7c) is an inhibitor of SIRT2 and induces apoptosis. SIRT2-IN-13 selectively inhibits colon cancer and leukemia cells and arrests the cell cycle in the G2 phase.
    SIRT2-IN-13
  • HY-118109
    SIRT3-IN-2
    		Inhibitor
    SIRT3-IN-2 (Inhibitor scaffolds in Scheme 1) is a SIRT3 inhibitor, reducing SIRT3 activity by 39% at a concentration of 200 µM. SIRT3-IN-2 is promising for research into metabolic homeostasis and tumor suppression.
    SIRT3-IN-2
  • HY-108331R
    3-TYP (Standard)
    		Inhibitor
    3-TYP (Standard) is the analytical standard of 3-TYP (HY-108331). This product is intended for research and analytical applications. 3-TYP is an inhibitor of SIRT3 (IC50of 38 μM) and an inhibitor of Methionine Adenosyltransferase (MAT) 2 and Indoleamine 2,3-Dioxygenase (IDO). There may be many off-target sites for 3-TYP that need to be examined, such as NAD-dependent enzymes, including dehydrogenases.
    3-TYP (Standard)
  • HY-101073R
    Salermide (Standard)
    		Inhibitor
    Salermide (Standard) is the analytical standard of Salermide (HY-101073). This product is intended for research and analytical applications. Salermide is an inhibitor of Sirt1 and Sirt2; can cause strong cancer-specific apoptotic cell death.
    Salermide (Standard)
  • HY-159126
    SIRT2-IN-15
    		Inhibitor
    SIRT2-IN-15 (compound 1) is a SIRT2 deacetylase and deamyloacylase inhibitor with IC50 7 and 37 μM, respectively.
    SIRT2-IN-15
  • HY-103636R
    PROTAC Sirt2 Degrader-1 (Standard)
    		Inhibitor
    PROTAC Sirt2 Degrader-1 (Standard) is the analytical standard of PROTAC Sirt2 Degrader-1 (HY-103636). This product is intended for research and analytical applications. PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a bona fide Cereblon ligand for E3 ubiquitin ligase. PROTAC Sirt2 Degrader-1 shows an IC50 of 0.25 μM for Sirt2, with no effect on Sirt1/Sirt3 (IC50s>100 μM).
    PROTAC Sirt2 Degrader-1 (Standard)
  • HY-174299
    SIRT1-IN-6
    		Inhibitor
    SIRT1-IN-6 (Compound NP1) is a SIRT1 inhibitor (IC50: 9.7 μM). SIRT1-IN-6 increases p53 acetylation. SIRT1-IN-6 can be used for research of prophylaxis and neurodegenerative diseases or cancer.
    SIRT1-IN-6
  • HY-101278R
    Thiomyristoyl (Standard)
    		Inhibitor
    Thiomyristoyl (Standard) is the analytical standard of Thiomyristoyl (HY-101278). This product is intended for research and analytical applications. Thiomyristoyl is a potent and specific SIRT2 inhibitor with an IC50 of 28 nM.
    Thiomyristoyl (Standard)
  • HY-103721R
    SIRT6-IN-2 (Standard)
    		Inhibitor
    SIRT6-IN-2 (Standard) is the analytical standard of SIRT6-IN-2 (HY-103721). This product is intended for research and analytical applications. SIRT6-IN-2 (Compound 5) is a selective and competitive SIRT6 inhibitor (IC50: 34 μM). SIRT6-IN-2 increases acetylation of H3K9 and increases glucose uptake in cultured cells. SIRT6-IN-2 also reduces T cell proliferation. SIRT6-IN-2 has immunosuppressive and chemosensitizing effects.
    SIRT6-IN-2 (Standard)
  • HY-100732R
    Cambinol (Standard)
    		Inhibitor
    Cambinol (Standard) is the analytical standard of Cambinol. This product is intended for research and analytical applications. Cambinol is a SIRT1 and SIRT2 inhibitor with IC50 values of 56 μM and 59 μM, respectively. Cambinol is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor).
    Cambinol (Standard)
  • HY-117442
    A2B57
    		Inhibitor
    A2B57 is a selective inhibitor for SIRT 2 with an IC50 of 6.3 µM.
    A2B57
  • HY-W109401
    SIRT-IN-6
    		Inhibitor
    SIRT-IN-6 (Compound 14) is a pan-inhibitor of SIRT1/2/3 with IC50 values of >50 μM. SIRT-IN-6 is promising for research of metabolic, inflammatory, oncologic and neurodegenerative disorders.
    SIRT-IN-6
  • HY-13515R
    Sirtinol (Standard)
    		Inhibitor
    Sirtinol (Standard) is the analytical standard of Sirtinol. This product is intended for research and analytical applications. Sirtinol is a sirtuin (SIRT) inhibitor, with IC50s of 48 μM, 57.7 μM and 131 μM for ySir2, hSIRT2 and hSIRT2, respectively.
    Sirtinol (Standard)
  • HY-101465R
    AK-1 (Standard)
    		Inhibitor
    AK-1 (Standard) is the analytical standard of AK-1 (HY-101465). This product is intended for research and analytical applications. AK-1 is a potent, specific and cell-permeable SIRT2 inhibitor, with an IC50 of 12.5 μM.
    AK-1 (Standard)
  • HY-107454R
    OSS_128167 (Standard)
    		Inhibitor
    OSS_128167 (Standard) is the analytical standard of OSS_128167 (HY-107454). This product is intended for research and analytical applications. OSS_128167 is a potent selective sirtuin 6 (SIRT6) inhibitor with IC50s of 89 μM, 1578 μM and 751 μM for SIRT6, SIRT1 and SIRT2, respectively. OSS_128167 has anti-HBV activity that inhibits HBV transcription and replication. OSS_128167 has anti-cancer, anti-inflammation and anti-viral effects.
    OSS_128167 (Standard)
  • HY-B0150S3
    Nicotinamide-d3
    		Inhibitor
    Nicotinamide-d3 (Niacinamide-d3) is deuterium labeled Nicotinamide. Nicotinamide is a form of vitamin B3 or niacin. Nicotinamide Hydrochloride inhibits SIRT2 activity (IC50: 2 μM). Nicotinamide also inhibits SIRT1. Nicotinamide increases cellular NAD+, ATP, ROS levels. Nicotinamide inhibits tumor growth and improves survival. Nicotinamide also has anti-HBV activity.
    Nicotinamide-d<sub>3</sub>
  • HY-178773
    SIRT2-IN-18
    		Inhibitor
    SIRT2-IN-18 (Compound 8) is a SIRT2 inhibitor with IC50s of 5.3  and 12.3 μM for SmSIRT2 and hSIRT2, respectively. SIRT2-IN-18 shows potent antischistosomal activities against both Liberian and Puerto Rican strains of Schistosoma mansoni and reduces schistosomula and adult worm pair viability, pairing, and egg production, with low cytotoxicity in mammalian cells. SIRT2-IN-18 increases histone H3 hyperacetylation and induces cytochrome c-mediated apoptosis.
    SIRT2-IN-18
  • HY-119889
    A1B11
    		Inhibitor
    A1B11 is a selective SIRT inhibitor (SIRT2:IC50=5.3 μM) that can be used in the study of neurodegenerative diseases.
    A1B11
  • HY-100578R
    AGK2 (Standard)
    		Inhibitor
    AGK2 (Standard) is the analytical standard of AGK2 (HY-100578). This product is intended for research and analytical applications. AGK2 is a selective SIRT2 inhibitor with an IC50 of 3.5 μM. AGK2 inhibits SIRT1 and SIRT3 with IC50s of 30 and 91 μM, respectively.
    AGK2 (Standard)
  • HY-N1926R
    Dihydrocoumarin (Standard)
    		Inhibitor
    Dihydrocoumarin (Standard) is the analytical standard of Dihydrocoumarin. This product is intended for research and analytical applications. Dihydrocoumarin is a compound found in Melilotus officinalis. Dihydrocoumarin is a yeast Sir2p inhibitor. Dihydrocoumarin also inhibits human SIRT1 and SIRT2 with IC50s of 208 μM and 295 μM, respectively.
    Dihydrocoumarin (Standard)
Cat. No. Product Name / Synonyms Application Reactivity
Sirtuin Isoform Comparison

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