Topoisomerase
Topoisomerases are enzymes that regulate the overwinding or underwinding of DNA. The winding problem of DNA arises due to the intertwined nature of its double-helical structure. Topoisomerases are isomerase enzymes that act on the topology of DNA. Type I topoisomerase cuts one strand of a DNA double helix, relaxation occurs, and then the cut strand is reannealed. Type I topoisomerases are subdivided into two subclasses: type IA topoisomerases, which share many structural and mechanistic features with the type II topoisomerases, and type IB topoisomerases, which utilize a controlled rotary mechanism. Type II topoisomerase cuts both strands of one DNA double helix, pass another unbroken DNA helix through it, and then reanneal the cut strands. This class is also split into two subclasses: type IIA and type IIB topoisomerases, which possess similar structure and mechanisms.
Topoisomerase Isoform Specific Products
All Product Categories
-
Topoisomerase Inhibitors
(751)
View all products
-
Topoisomerase Agonists
(2)
View all products
-
Topoisomerase Modulator
(1)
View all products
-
Topoisomerase Inducer
(1)
View all products
-
Topoisomerase Degraders
(3)
View all products
-
Topoisomerase Controls
(3)
View all products
-
Topoisomerase Ligands
(2)
View all products
-
Topoisomerase Proteins
(1)
View all products
-
DNA topoisomerase II Proteins
(1)
View all products
-
Topoisomerase Related Products (827)
Related Products (827)
-
Recombinant Proteins (1)
-
Antibodies (4)
-
Topoisomerase Isoform Comparison
-
N-(DBCO-PEG4)-N-(PEG4-Val-Cit-PAB-MMAE)-N-(PEG4-Val-Cit-PAB-Exatecan)
0 ImagesCat. No.: HY-177683N-(DBCO-PEG4)-N-(PEG4-Val-Cit-PAB-MMAE)-N-(PEG4-Val-Cit-PAB-Exatecan) is a drug-linker conjugate for ADC (Drug-Linker Conjugate for ADC), consisting of a tubulin polymerization inhibitor MMAE (HY-15162) and a DNA topoisomerase I inhibitor Exatecan (HY-13631), and an ADC linker composition. N-(DBCO-PEG4)-N-(PEG4-Val-Cit-PAB-MMAE)-N-(PEG4-Val-Cit-PAB-Exatecan) can be used for synthesis of ADCs and for cancer research.
-
N-(Mal)-N-(PEG8-Val-Cit-PAB-MMAE)-N-(PEG8-Val-Cit-PAB-Exatecan)
0 ImagesCat. No.: HY-177681N-(Mal)-N-(PEG8-Val-Cit-PAB-MMAE)-N-(PEG8-Val-Cit-PAB-Exatecan) is a drug-linker conjugate for ADC (Drug-Linker Conjugate for ADC), consisting of a tubulin polymerization inhibitor MMAE (HY-15162) and a DNA topoisomerase I inhibitor Exatecan (HY-13631), and an ADC linker composition. N-(Mal)-N-(PEG8-Val-Cit-PAB-MMAE)-N-(PEG8-Val-Cit-PAB-Exatecan) can be used for synthesis of ADCs and for cancer research.
-
Top1 inhibitor 1
0 ImagesTop1 inhibitor 1 (compound 28) is a potent human topoisomerase I (Top1) inhibitor with an IC50 value of 29 nM.
-
(5-Cl)-Exatecan
0 ImagesCat. No.: HY-160806CAS No.: 2813268-66-3(5-Cl)-Exatecan is a derivative of Exatecan (HY-13631) and a DNA topoisomerase inhibitor. (5-Cl)-Exatecan serves as the cytotoxic payload component in antibody-drug conjugates (ADC) targeting ROR1-positive cancers. (5-Cl)-Exatecan is applicable for the research of ROR1-positive cancers.
-
Camptothecin (Standard)
0 ImagesSynonyms: Campathecin (Standard); (S)-(+)-Camptothecin (Standard); CPT (Standard)Camptothecin (Standard) (Campathecin (Standard)) is the analytical standard of Camptothecin (HY-16560). This product is intended for research and analytical applications. Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC50 of 679 nM. Camptothecin (CPT) exhibits powerful antineoplastic activity against colorectal, breast, lung and ovarian cancers, modulates hypoxia-inducible factor-1α (HIF-1α) activity by changing microRNAs (miRNA) expression patterns in human cancer cells.
-
Decyclohexanamine-Exatecan
0 ImagesDecyclohexanamine-Exatecan (compound a) is a Camptothecin derivative, with a structure containing Exatecan (HY-13631), which can be used as a ADC cytotoxin.
-
XK469
0 ImagesSynonyms: NSC 697887XK469 (NSC 697887) is a quinoxaline-based topoisomerase II inhibitor. XK469 exhibits antiproliferative activity against neuroblastoma cells. XK469 can be used in the research of neuroblastoma.
-
Edotecarin
0 ImagesSynonyms: J 107088; PF 804950Edotecarin is a potent inhibitor of topoisomerase I that can induces single-strand DNA cleavage, with IC50 of 50 nM.
-
CH-0793076 TFA
0 ImagesSynonyms: TP3076 TFACH-0793076 (TP3076) TFA, a hexacyclic camptothecin analog, is active drug and major metabolite of TP300. CH-0793076 TFA inhibits DNA topoisomerase I with an IC50 of 2.3 μM. CH-0793076 TFA is efficacious against cells expressing BCRP (breast cancer resistance protein).
-
BWC0977
0 ImagesCat. No.: HY-162959CAS No.: 2254567-00-3BWC0977 acts as an inhibitor of bacterial Topoisomerase. BWC0977 stabilizes single-strand DNA breaks, inhibits DNA supercoiling and decatenation activities, binds to GyrA and ParC residues, and activates the SOS response. BWC0977 can be used in research related to multidrug-resistant bacterial infections.
-
Zabofloxacin
0 ImagesCat. No.: HY-106410CAS No.: 219680-11-2Synonyms: DW-224a Free baseZabofloxacin (DW-224a Free base) is a potent and seletive inhibitor of the bacterial type II and IV topoisomerases. Zabofloxacin has excellent activity against gram-positive pathogens including Steptococcus aureus, Streptococcus pyogenes and S.pneumonia. Zabofloxacin is a novel fluoronaphthyridone quinolone that is considered as an alternative antibiotic for treatment of quinolone-susceptible (QSSP) and quinolone-resistant gonorrhea (QRSP).
-
SN-38-CM2
0 ImagesCat. No.: HY-157797CAS No.: 2376127-86-3SN-38-CM2 is a split esterase, and shows >95% conversion to SN-38 within 5 min in vitro. SN-38-CM2 induces protein-protein interactions (PPI)-dependent esterase to mediate cell death in MDA-MB-231 cells.
-
Aminocaproyl-Val-Cit-PABC-Exatecan
0 ImagesCat. No.: HY-171931CAS No.: 3029114-39-1Aminocaproyl-Val-Cit-PABC-Exatecan is a drug-linker conjugate for ADC, consiting of a cleavable linker (Aminocaproyl-Val-Cit-PABC) and Exatecan (HY-13631) (topoisomerase I inhibitor). Aminocaproyl-Val-Cit-PABC-Exatecan can be used for ADC molecues synthesis.
-
Indotecan hydrochloride
0 ImagesSynonyms: LMP-400 hydrochloride; NSC-724998 hydrochlorideIndotecan hydrochloride, an indenoisoquinoline derivative, is a potent Topoisomerase I inhibitor, with IC50s of 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively. Indotecan hydrochloride prevents the relaxation of supercoiled DNA and can be used for the research of visceral leishmaniasis.
-
Gly-7-MAD-MDCPT TFA
0 ImagesCat. No.: HY-132164BGly-7-MAD-MDCPT (Compound 4b) TFA is an anticancer agent. Gly-7-MAD-MDCPT TFA is a Camptothecin (HY-16560) compound, which shows cytotoxicity to various cancer cells with IC50 values of 10-1000 nM.
-
SW044248
0 ImagesSW044248 is a non-canonical topoisomerase I inhibitor, and selectively toxic for certain non-small cell lung cancer (NSCLC) cell lines.
-
Betulinic acid-d3
0 ImagesCat. No.: HY-W744739Purity: 99%Synonyms: Lupatic acid-d3; Betulic acid-d3Betulinic acid-d3 (Lupatic acid-d3) is a deuterium labeled Betulinic acid (HY-10529). Betulinic acid is a natural pentacyclic triterpenoid, acts as a eukaryotic topoisomerase I inhibitor, with an IC50 of 5 μM, and possesses anti-HIV, anti-malarial, anti-inflammatory and anti-tumor properties. Betulinic acid can cross the blood-brain barrier.
-
1,4-Di-tert-butylbenzene
0 ImagesCat. No.: HY-W087058CAS No.: 1012-72-21,4-Di-tert-butylbenzene is a volatile compound identified in the hexane extracts of corn cob and green millet. 1,4-Di-tert-butylbenzene shows potent inhibition against receptor proteins of Bacterial type II topoisomerase (4PLB and LpxC) in docking analysis.
-
(5-Cl)-Exatecan TFA
0 ImagesCat. No.: HY-160806A(5-Cl)-Exatecan TFA is a derivative of Exatecan (HY-13631) and a DNA topoisomerase inhibitor. (5-Cl)-Exatecan TFA serves as the cytotoxic payload component in antibody-drug conjugates (ADC) targeting ROR1-positive cancers. (5-Cl)-Exatecan TFA is applicable for the research of ROR1-positive cancers.
-
Pixantrone free base
0 ImagesCat. No.: HY-13727CAS No.: 144510-96-3Synonyms: BBR 2778 free basePixantrone (BBR 2778 (free base)), a mitoxantrone analog, is a topoisomerase II inhibitor and DNA intercalator, with anti-tumor activity.
