1. Cell Cycle/DNA Damage
  2. Topoisomerase
  3. SW044248

SW044248 

Cat. No.: HY-19637 Purity: 99.60%
Handling Instructions

SW044248 is a non-canonical topoisomerase I inhibitor, and selectively toxic for certain non-small cell lung cancer (NSCLC) cell lines.

For research use only. We do not sell to patients.

SW044248 Chemical Structure

SW044248 Chemical Structure

CAS No. : 522650-83-5

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10 mM * 1 mL in DMSO USD 83 In-stock
Estimated Time of Arrival: December 31
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10 mg USD 130 In-stock
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50 mg USD 460 In-stock
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100 mg USD 750 In-stock
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Description

SW044248 is a non-canonical topoisomerase I inhibitor, and selectively toxic for certain non-small cell lung cancer (NSCLC) cell lines.

IC50 & Target[1]

Topoisomerase I

 

In Vitro

SW044248 is a non-canonical Top1 inhibitor, and is selectively toxic for certain NSCLC cell lines. SW044248 shows no effect on Top2. SW044248 (2, 5, 10 μM) rapidly inhibits transcription, translation and DNA synthesis in sensitive cells (HCC4017 and H292 cells) but not insensitive cells (HBEC30KT cells and HCC44 cells). SW044248 (10 μM) rapidly activates the integrated stress response through kinases GCN2 and PKR. The inhibition of Top1 in HCC4017 cells is helpful to the toxicity of SW044248. SW044248 (5, 10 μM) shows no effect on HBEC30KT and HCC44 cell lines due to the up-regulation of p21CDKN1A[1]. SW044248 is selectively toxic in 18/74 NSCLC lines[2].

Molecular Weight

421.52

Formula

C₂₂H₂₃N₅O₂S

CAS No.

522650-83-5

SMILES

CCC(SC1=NN=C2C(N(CC)C3=C2C=CC=C3)=N1)C(NC4=CC=CC=C4OC)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 30 mg/mL (71.17 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3724 mL 11.8618 mL 23.7237 mL
5 mM 0.4745 mL 2.3724 mL 4.7447 mL
10 mM 0.2372 mL 1.1862 mL 2.3724 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Cell Assay
[1]

100 μL of 50,000 cells/mL cell suspensions of individual cell lines are added in wells in 96-well plates. The next day, 100 μL of cell medium substituted with 2X concentration of SW044248 or camptothecin or DMSO in triplicates is added to each well. After 96 and 120 hours the ATP concentration in the wells is measured with CelTiter-Glo. The luminescence is measured with an plate reader[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

Purity: 99.60%

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SW044248
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