2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Topoisomerase
  5. Topoisomerase Control

Topoisomerase Control

Topoisomerase Isoform Comparison

Topoisomerase Controls (4):

Cat. No. Product Name Effect Purity
  • HY-157797
    SN-38-CM2
    		Control
    SN-38-CM2 is a split esterase, and shows >95% conversion to SN-38 within 5 min in vitro. SN-38-CM2 induces protein-protein interactions (PPI)-dependent esterase to mediate cell death in MDA-MB-231 cells.
  • HY-16560B
    (R)-Camptothecin
    		Control
    (R)-Camptothecin is an enantiomer of Camptothecin (CPT), is inactive as an inhibitor of the DNA religation reaction and consequently do not poison Top1.
  • HY-154797
    N,N-Dimethyldoxorubicin
    		Control
    N,N-Dimethyldoxorubicin is a Doxorubicin (HY-15142A) analogue. N,N-Dimethyldoxorubicin shows cytotoxicity against a panel of tumor cell lines (IC50s < 0.3 μM).
  • HY-49556
    (S)-Benzyl 2-cyclopropyl-2-hydroxyacetate
    		Control 98.69%
    (S)-Benzyl 2-cyclopropyl-2-hydroxyacetate is an intermediate reactant in the synthesis of Camptothecin (HY-16560). Camptothecin is an inhibitor of the DNA topoisomerase Topo I, withIC50=679 nM.