1. Anti-infection
    Cell Cycle/DNA Damage
  2. Bacterial
    Topoisomerase
  3. Zabofloxacin

Zabofloxacin (Synonyms: DW-224a Free base)

Cat. No.: HY-106410
Handling Instructions

Zabofloxacin (DW-224a Free base) is a potent and seletive inhibitor of the bacterial type II and IV topoisomerases. Zabofloxacin has excellent activity against gram-positive pathogens including Steptococcus aureusStreptococcus pyogenes and S.pneumonia. Zabofloxacin is a novel fluoronaphthyridone quinolone that is considered as an alternative antibiotic for treatment of quinolone-susceptible (QSSP) and quinolone-resistant gonorrhea (QRSP).

For research use only. We do not sell to patients.

Zabofloxacin Chemical Structure

Zabofloxacin Chemical Structure

CAS No. : 219680-11-2

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Description

Zabofloxacin (DW-224a Free base) is a potent and seletive inhibitor of the bacterial type II and IV topoisomerases. Zabofloxacin has excellent activity against gram-positive pathogens including Steptococcus aureusStreptococcus pyogenes and S.pneumonia. Zabofloxacin is a novel fluoronaphthyridone quinolone that is considered as an alternative antibiotic for treatment of quinolone-susceptible (QSSP) and quinolone-resistant gonorrhea (QRSP)[1].

IC50 & Target

Topoisomerase I

 

Topoisomerase II

 

In Vitro

Zabofloxacin shows a highly potent in vitro activity against clinical isolates of penicillin-sensitive S. pneumoniae (minimum inhibitory concentration, MIC90: 0.03 mg/L) and penicillin-resistant S. pneumoniae (MIC90: 0.03 mg/L). Against quinolone-resistant S. pneumoniae, zabofloxacin (MIC90: 1 mg/L) is more active than ciprofloxacin, sparfloxacin, and moxifloxacin[1].

Clinical Trial
Molecular Weight

401.39

Formula

C₁₉H₂₀FN₅O₄

CAS No.

219680-11-2

SMILES

CO/N=C1C2(CNC2)CN(C3=C(F)C=C4C(N(C5CC5)C=C(C(O)=O)C4=O)=N3)C/1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

ZabofloxacinDW-224aBacterialTopoisomeraseSteptococcusaureuspyogenesS.pneumoniaantibioticQSSPQRSPInhibitorinhibitorinhibit

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Zabofloxacin
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HY-106410
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