1. GPCR/G Protein
    Neuronal Signaling
  2. Neurokinin Receptor
  3. Vapreotide

Vapreotide (Synonyms: RC160; BMY 41606)

Cat. No.: HY-P0061 Purity: 98.83%
Handling Instructions

Vapreotide is a neurokinin-1 (NK1) receptor antagonist, with an IC50 of 330 nM.

For research use only. We do not sell to patients.

Vapreotide Chemical Structure

Vapreotide Chemical Structure

CAS No. : 103222-11-3

Size Price Stock Quantity
10 mM * 1  mL in Water USD 418 In-stock
Estimated Time of Arrival: December 31
1 mg USD 132 In-stock
Estimated Time of Arrival: December 31
5 mg USD 264 In-stock
Estimated Time of Arrival: December 31
10 mg USD 336 In-stock
Estimated Time of Arrival: December 31
50 mg USD 720 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Vapreotide:

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Vapreotide is a neurokinin-1 (NK1) receptor antagonist, with an IC50 of 330 nM.

IC50 & Target

330 nM (NK1R)[1].

In Vitro

Vapreotide attenuates the effect of SP on calcium release in a concentration-dependent manner. The concentration required for Vapreotide to completely inhibit the effect of SP is about 100 times higher than that required for the NK1R antagonist aprepitant. The effect of Vapreotide on cell proliferation is mediated primarily by SSTR2. In order to further establish the NK1R antagonist effect of Vapreotide, U373MG cells are pretreated with SSTR2 selective antagonist CYN followed by incubation with Vapreotide and SP stimulation. The results show that pretreatment with CYN does not reverse the inhibitory effect of Vapreotide on SP-stimulated IL-8 mRNA expression. Vapreotide reduces HIV-1 replication in MDM as indicated by limited HIV gag mRNA expression compared to control MDM. In addition, SP treatment (10 μM) reverses Vapreotide inhibition of HIV-1 replication in MDM. This observation indicates that the inhibition of HIV-1 replication by Vapreotide is most likely due to its interaction with NK1R[1].

Clinical Trial
Molecular Weight







Phe-Cys-Tyr-Trp-Lys-Val-Cys-Trp-NH2 (Disulfide bridge: Cys2-Cys7)

Sequence Shortening

FCYWKVCW-NH2 (Disulfide bridge: Cys2-Cys7)


[FCYWKVCW-NH2(Disulfide bridge: Cys2-Cys7)]


Room temperature in continental US; may vary elsewhere.

Protect from light
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (88.39 mM; Need ultrasonic)

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8839 mL 4.4194 mL 8.8388 mL
5 mM 0.1768 mL 0.8839 mL 1.7678 mL
10 mM 0.0884 mL 0.4419 mL 0.8839 mL
*Please refer to the solubility information to select the appropriate solvent.
Cell Assay

The HEK293-NK1R cells and U373MG cells are incubated with or without Vapreotide (0, 5, 10, 20 μM) for 10 minutes and then incubated with or without SP for 3 hours. In some experiments, cells are first incubated with CYN for 10 minutes, and then Vapreotide is added and incubated for an additional 10 minutes, followed by stimulation with SP for 3 hours. Mock treated cells are used as controls[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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VapreotideRC160BMY 41606RC 160RC-160BMY41606BMY-41606Neurokinin ReceptorNK receptorInhibitorinhibitorinhibit

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