1. Peptides

Vapreotide (Synonyms: RC160; BMY 41606)

Cat. No.: HY-P0061
Handling Instructions

Vapreotide, a synthetic analog of somatostatin, has NK1R antagonist activity.

For research use only. We do not sell to patients.
Vapreotide Chemical Structure

Vapreotide Chemical Structure

CAS No. : 103222-11-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO $348 In-stock
1 mg $110 In-stock
5 mg $220 In-stock
10 mg $280 In-stock
50 mg $600 In-stock
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Other Forms of Vapreotide:

  • Biological Activity

  • Protocol

  • Technical Information

  • References

Description

Vapreotide, a synthetic analog of somatostatin, has NK1R antagonist activity. target: NK1R In vitro: Vapreotide has NK1R antagonist activity. Vapreotide attenuates SP-triggered intracellular calcium increases and NF-κB activation in a dose-dependent manner. Vapreotide also inhibits SP-induced IL-8 and MCP-1 production in HEK293-NK1R and U373MG cell lines. Vapreotide inhibits HIV-1 infection of human MDM in vitro, an effect that is reversible by SP pretreatment.[1] In vivo: Vapreotide decreases portal pressure and blood flow of collateral circulation in rats with cirrhosis. Vapreotide administrated via the intravenous route is simple to use, with practically no contraindications and few, usually minor, side effects.

Clinical Trial
NCT Number Sponsor Condition Start Date Phase
NCT00014651 Mayo Clinic|National Cancer Institute (NCI) Pancreatic Cancer|Perioperative/Postoperative Complications March 2001 Phase 3
NCT00331188 Debiovision Esophageal Varices|Portal Hypertension|Gastric Varices|Esophageal Bleeding May 2006 Phase 3
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References
Preparing Stock Solutions
Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 0.8839 mL 4.4194 mL 8.8388 mL
5 mM 0.1768 mL 0.8839 mL 1.7678 mL
10 mM 0.0884 mL 0.4419 mL 0.8839 mL
References
Molecular Weight

1131.37

Formula

C₅₇H₇₀N₁₂O₉S₂

CAS No.

103222-11-3

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
Vapreotide
Cat. No.:
HY-P0061
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