2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Fosribnicotinamide

β-Nicotinamide mononucleotide  (Synonyms: NMN; β-NM; ニコチンアミドモノヌクレオチド)

製品番号: HY-F0004 純度: 99.94%
COA 取扱説明書 Technical Support

Fosribnicotinamide (β-nicotinamide mononucleotide) is a product of the nicotinamide phosphoribosyltransferase (NAMPT) reaction and a key NAD+ intermediate. The pharmacological activities of Fosribnicotinamide include its role in cellular biochemical functions, cardioprotection, diabetes, Alzheimer's disease, and complications associated with obesity.

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CAS 番号 : 1094-61-7

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 41 在庫あり
Solution
10 mM * 1 mL in Water USD 41 在庫あり
Solid
5 mg $38 在庫あり
10 mg $60 在庫あり
50 mg $144 在庫あり
100 mg $216 在庫あり
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カスタマーレビュー

Based on 27 publication(s) in Google Scholar

Other Forms of Fosribnicotinamide:

β-Nicotinamide mononucleotide 関連抗体

Top Publications Citing Use of Products

顧客検証

Bio/Physico-chemical Assay
WB
In Vivo Efficacy Study
Flow Cytometry

    Fosribnicotinamide purchased from MedChemExpress. Usage Cited in: Theranostics. 2024 Apr 28;14(7):2794-2815.  [Abstract]

    RAW264.7 cells were treated with FK866 (1 nM) and β-NMN (100 μΜ) 30 min before the addition of TGF-β1 (20 ng/mL) for 24 h，ELISA assay of NAMPT releasing in the culture supernatant (left), Quantification of the intracellular NAD level using a commercial kit (right).

    Fosribnicotinamide purchased from MedChemExpress. Usage Cited in: Cell Metab. 2021 Jan 5;33(1):110-127.e5.  [Abstract]

    Tumor growth curves and tumor burdens in C57BL/6 mice injected subcutaneously with sgCtrl or sgNampt liver cancer cells (Hepa1–6) for 3 weeks (n = 6) and C57BL/6 mice injected subcutaneously with Hepa1–6 cells with solvent control (Ctrl) or NMN (Fosribnicotinamide;300 mg/kg body weight; daily;intraperitoneal injection for 2 weeks beginning on day 7 after LLC cells, Pan02 cells, or Hepa1-6-CD38 cells were subcutaneously implanted).

    Fosribnicotinamide purchased from MedChemExpress. Usage Cited in: Cell Metab. 2021 Jan 5;33(1):110-127.e5.  [Abstract]

    Representative flow staining indicated cells in tumor xenograft of indicated groups.(NMN, Fosribnicotinamide;300 mg/kg body weight; daily;intraperitoneal injection for 2 weeks beginning on day 7 after LLC cells, Pan02 cells, or Hepa1-6-CD38 cells were subcutaneously implanted)

    Fosribnicotinamide purchased from MedChemExpress. Usage Cited in: Cell Metab. 2021 Jan 5;33(1):110-127.e5.  [Abstract]

    Representative flow staining (left panel) and frequency (right panel) of CD8+ T cells and PD-1+ CD8+ T cells in tumor xenograft of indicated groups ((NMN, Fosribnicotinamide;300 mg/kg body weight; daily,ip; PD-L1 antibodies (100 μg of anti-PD-L1 per mouse; twice a week) or combination via intraperitoneal injection for 2 weeks beginning on day 7 after LLC cells, Pan02 cells, or Hepa1-6-CD38 cells were subcutaneously implanted).

    Fosribnicotinamide purchased from MedChemExpress. Usage Cited in: Proc Natl Acad Sci U S A. 2019 Sep 24;116(39):19626-19634.  [Abstract]

    p53−/− mice were treated per divided lowdose Dox protocol and with either vehicle control or NMN (Fosribnicotinamide; 500 mg/kg, i.p., 3 times per week on alternating days) over the duration of the entire study. Unless indicated, all analyses were performed at study week 10. LV ejection fraction (LVEF) of p53−/−mice treated with Dox only or Dox plus NMN was measured by echocardiogram at study week 7 and 10 (n = 8). Mitochondrial respiration and ATP levels were measured in cardiac tissue (n ≥ 3).

    Fosribnicotinamide purchased from MedChemExpress. Usage Cited in: Proc Natl Acad Sci U S A. 2019 Sep 24;116(39):19626-19634.  [Abstract]

    p53−/− mice were treated per divided lowdose Dox protocol and with either vehicle control or NMN (Fosribnicotinamide; 500 mg/kg, i.p., 3 times per week on alternating days) over the duration of the entire study. Unless indicated, all analyses were performed at study week 10. Immunoblot of representative mtDNA-encoded protein MT-CO1 in cardiac tissue. GAPDH is shown as protein loading control.

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    製品説明

    Fosribnicotinamide (β-nicotinamide mononucleotide) is a product of the nicotinamide phosphoribosyltransferase (NAMPT) reaction and a key NAD+ intermediate. The pharmacological activities of Fosribnicotinamide include its role in cellular biochemical functions, cardioprotection, diabetes, Alzheimer's disease, and complications associated with obesity[1].

    IC50 & Target

    Human Endogenous Metabolite

     

    体外実験

    Fosribnicotinamide (β-nicotinamide mononucleotide) has several beneficial pharmacological activities. Mostly mediated by its involvement in NAD+ biosynthesis, the pharmacological activities of NMN include its role in cellular biochemical functions, cardioprotection, diabetes, Alzheimer's disease, and complications associated with obesity[1].
    The intracellular NAD+ levels are significantly decreased by knockdown or knockout of Nampt (Nampt KD or Nampt KO) or treatment with Nampt inhibitor FK866, whereas NAD+ levels are dramatically increased by supplement of NAD+ precursors NAM or NMN (0.5-1 mM). NAD+ precursor NMN treatment inhibited CD8+ T cells activation and function[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    β-Nicotinamide mononucleotide 関連抗体
    体内実験

    Fosribnicotinamide (β-nicotinamide mononucleotide) (500 mg/kg; i.p.; 3 times per week for 7-10 week) prevents mtDNA damage and Dox-induced cardiac dysfunction[3].
    Nampt KO markedly inhibits tumor progression, whereas Nampt metabolite Fosribnicotinamide (300 mg/kg body weight; i.p.; once every two days for 2 weeks) significantly promotes tumor growth in C57BL/6 mice (bearing wildtype Hepa1-6 cells). The reduction and increase in NAD+ level of respective Nampt KO and Fosribnicotinamide-treated tumors are confirmed[2].
    Fosribnicotinamide ameliorates glucose intolerance by restoring NAD+ levels in HFD-induced T2D mice.Fosribnicotinamide also enhances hepatic insulin sensitivity and restores gene expression related to oxidative stress, inflammatory response, and circadian rhythm, partly through SIRT1 activation[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: C57BL6 mice (p53−/− mice)[3]
    Dosage: 500 mg/kg
    Administration: I.p.; 3 times per week for 7-10 week
    Result: Prevented the significant decline in cardiac function of Dox-treated p53−/− mice (study week 7 versus 10) along with rescuing the decreased mitochondrial respiration and tissue ATP depletion caused by Doxorubicin (Dox).
    分子量

    334.22

    分子式

    C11H15N2O8P
    CAS 番号
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O[C@@H]1[C@H](O)[C@@H](COP(O)([O-])=O)O[C@H]1[N+]2=CC=CC(C(N)=O)=C2
    Structure Classification
    Initial Source
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    4°C, protect from light

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
    溶剤 & 溶解度
    体外: 

    H2O : 83.33 mg/mL (249.33 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.9920 mL 14.9602 mL 29.9204 mL
    5 mM 0.5984 mL 2.9920 mL 5.9841 mL
    10 mM 0.2992 mL 1.4960 mL 2.9920 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 100 mg/mL (299.20 mM); Clear solution; Need ultrasonic

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    純度とドキュメンテーション

    純度: 99.94%

    COA (248 KB) HNMR (265 KB) RP-HPLC (205 KB) MS (67 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 2.9920 mL 14.9602 mL 29.9204 mL 74.8010 mL
    5 mM 0.5984 mL 2.9920 mL 5.9841 mL 14.9602 mL
    10 mM 0.2992 mL 1.4960 mL 2.9920 mL 7.4801 mL
    15 mM 0.1995 mL 0.9973 mL 1.9947 mL 4.9867 mL
    20 mM 0.1496 mL 0.7480 mL 1.4960 mL 3.7401 mL
    25 mM 0.1197 mL 0.5984 mL 1.1968 mL 2.9920 mL
    30 mM 0.0997 mL 0.4987 mL 0.9973 mL 2.4934 mL
    40 mM 0.0748 mL 0.3740 mL 0.7480 mL 1.8700 mL
    50 mM 0.0598 mL 0.2992 mL 0.5984 mL 1.4960 mL
    60 mM 0.0499 mL 0.2493 mL 0.4987 mL 1.2467 mL
    80 mM 0.0374 mL 0.1870 mL 0.3740 mL 0.9350 mL
    100 mM 0.0299 mL 0.1496 mL 0.2992 mL 0.7480 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Fosribnicotinamide Related Classifications

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    Keywords:

    Fosribnicotinamide1094-61-7β-Nicotinamide mononucleotide β-NM NMNEndogenous MetabolitecardioprotectiondiabetesAlzheimer'sdiseaseobesitycancerNADintermediateInhibitorinhibitorinhibit

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