2. Metabolic Enzyme/Protease
  3. Drug Metabolite Endogenous Metabolite
  4. Acetaminophen glucuronide

Acetaminophen glucuronide  (Synonyms: APAP-glu)

Cat. No.: HY-113083 Pureza: 99.96%
COA
SDS
Instrucciones de manejo Technical Support

Acetaminophen glucuronide (APAP-glu) is an inactive glucuronide metabolite of Acetaminophen (HY-66005). Acetaminophen is a selective cyclooxygenase-2 (COX-2) inhibitor and a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor.

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Acetaminophen glucuronide

Acetaminophen glucuronide Estructura química

No. CAS : 16110-10-4

Tamaño Precio Stock Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 En stock
Solution
10 mM * 1 mL in DMSO En stock
Solid
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10 mg En stock
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Other Forms of Acetaminophen glucuronide:

Acetaminophen glucuronide Related Antibodies

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Descripciòn

Acetaminophen glucuronide (APAP-glu) is an inactive glucuronide metabolite of Acetaminophen (HY-66005)[1][2]. Acetaminophen is a selective cyclooxygenase-2 (COX-2) inhibitor and a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor[3][4].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Acetaminophen is metabolized in the liver mainly by glucuronidation and sulfation, thus generating the nontoxic metabolites, Acetaminophen glucuronide (APAP-glu). Acetaminophen glucuronide is a substrate for both canalicular Mrp2 and basolateral Mrp3 in rodents[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Acetaminophen glucuronide Related Antibodies
Peso molecular

327.29

Fòrmula

C14H17NO8
No. CAS
Appearance

Solid

Color

White to light yellow

SMILES

OC([C@H]([C@H]([C@@H]([C@H]1O)O)O)O[C@H]1OC2=CC=C(C=C2)NC(C)=O)=O
Structure Classification
Initial Source
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvente y solubilidad
In Vitro: 

DMSO : 50 mg/mL (152.77 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0554 mL 15.2770 mL 30.5539 mL
5 mM 0.6111 mL 3.0554 mL 6.1108 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureza y Documentación

Purity: 99.96%

SDS (393 KB)

COA (248 KB) HNMR (133 KB) LCMS (339 KB)

Instrucciones de manejo (2659 KB)
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0554 mL 15.2770 mL 30.5539 mL 76.3849 mL
5 mM 0.6111 mL 3.0554 mL 6.1108 mL 15.2770 mL
10 mM 0.3055 mL 1.5277 mL 3.0554 mL 7.6385 mL
15 mM 0.2037 mL 1.0185 mL 2.0369 mL 5.0923 mL
20 mM 0.1528 mL 0.7638 mL 1.5277 mL 3.8192 mL
25 mM 0.1222 mL 0.6111 mL 1.2222 mL 3.0554 mL
30 mM 0.1018 mL 0.5092 mL 1.0185 mL 2.5462 mL
40 mM 0.0764 mL 0.3819 mL 0.7638 mL 1.9096 mL
50 mM 0.0611 mL 0.3055 mL 0.6111 mL 1.5277 mL
60 mM 0.0509 mL 0.2546 mL 0.5092 mL 1.2731 mL
80 mM 0.0382 mL 0.1910 mL 0.3819 mL 0.9548 mL
100 mM 0.0306 mL 0.1528 mL 0.3055 mL 0.7638 mL
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Acetaminophen glucuronide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Acetaminophen glucuronide16110-10-4APAP-gluDrug MetaboliteEndogenous MetabolitemetaboliteMrp2Mrp3Inhibitorinhibitorinhibit

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Acetaminophen glucuronide
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