2. GPCR/G Protein
  3. Adenosine Receptor
  4. Alloxazine

Alloxazine  (Synonyms: Isoalloxazine)

Art. -Nr.: HY-123085 Reinheit: 99.46%
COA
SDS
Handling Instructions Technical Support

Alloxazine is a selective A2b antagonist. Alloxazine completely block 5’N-Ethylcarboxamido adenosine (NECA)-mediated cyclic AMP accumulation with an IC50 of 2.9 μM. Alloxazine can be used for the research of cancer.

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Alloxazine

Alloxazine Chemische Struktur

CAS. Nr. : 490-59-5

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO Auf Lager
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Other Forms of Alloxazine:

Alloxazine Related Antibodies

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Alle Adenosine Receptor Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen
Adenosine A1 receptor (A1R) Adenosine A2A receptor (A2AR) Adenosine A2B receptor (A2BR) Adenosine A3 receptor (A3R)

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Beschreibung

Alloxazine is a selective A2b antagonist. Alloxazine completely block 5’N-Ethylcarboxamido adenosine (NECA)-mediated cyclic AMP accumulation with an IC50 of 2.9 μM. Alloxazine can be used for the research of cancer[1][2].

IC50 & Target

IC50: 2.9 μM (AMP)[1]
Cellular Effect
Cell Line Type Value Description References
NIH3T3 IC50
> 50 μM
Compound: 62
Inhibitory activity against platelet-derived growth factor receptor tyrosine kinase in Swiss 3T3 cells
Inhibitory activity against platelet-derived growth factor receptor tyrosine kinase in Swiss 3T3 cells
[PMID: 8667360]
In Vitro

Alloxazine (0-30 μM, 20 min) inhibits cyclic AMP production in PGT-β cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Alloxazine Related Antibodies

Cell Viability Assay[1]

Cell Line: PGT-β cells
Concentration: 0-30 μM
Incubation Time: 20 min
Result: Inhibited the cyclic AMP generation concentration-dependently with an IC50 of 2.9 μM.
In Vivo

Alloxazine (1 µmol/L; cortical surface suffusion for 0-20 min) suppresses NECA-induced vasodilation[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats[2]
Dosage: 1 µmol/L
Administration: Cortical surface suffusion; 1 µmol/L once
Result: Significantly suppressed vasodilation with increased EC25 value of 0.60 µmol/L.
Molekulargewicht

214.18

Formel

C10H6N4O2
CAS. Nr.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(N1)N=C2NC3=CC=CC=C3N=C2C1=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Lösungsmittel & Löslichkeit
In Vitro: 

DMSO : 5 mg/mL (23.34 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.6690 mL 23.3449 mL 46.6897 mL
5 mM 0.9338 mL 4.6690 mL 9.3379 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molaritätsrechner

  • Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Reinheit & Dokumentation

Purity: 99.46%

SDS (393 KB)

COA (250 KB) HNMR (246 KB) LCMS (90 KB)

Handling Instructions (2659 KB)
Verweise

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.6690 mL 23.3449 mL 46.6897 mL 116.7243 mL
5 mM 0.9338 mL 4.6690 mL 9.3379 mL 23.3449 mL
10 mM 0.4669 mL 2.3345 mL 4.6690 mL 11.6724 mL
15 mM 0.3113 mL 1.5563 mL 3.1126 mL 7.7816 mL
20 mM 0.2334 mL 1.1672 mL 2.3345 mL 5.8362 mL
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Alloxazine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Alloxazine490-59-5IsoalloxazineAdenosine ReceptorP1 receptorNECAcancerAMPInhibitorinhibitorinhibit

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