AMP-PCP 

AMP-PCP is an ATP analogue and can bind to Hsp90 N-terminal domain with a K_d value of 3.8 μM. AMP-PCP binding favors the formation of the active homodimer of Hsp90^[1].

AMP-PCP binding favors the formation of the active homodimer of Hsp90 by enhancing the slow-motion featured conformational exchanges of those residues (A117-A141) within the lid segment (A111-G135) and around region. In total, 170 non-proline residues are identified for the triple-labeled Hsp90 bound with AMP-PCP^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

505.21

C₁₁H₁₈N₅O₁₂P₃

3469-78-1

O[C@H]1[C@@H](O[C@H](COP(OP(CP(O)(O)=O)(O)=O)(O)=O)[C@H]1O)N2C3=C(C(N)=NC=N3)N=C2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Zhang H, et al. A dynamic view of ATP-coupled functioning cycle of Hsp90 N-terminal domain. Sci Rep. 2015 Apr 13;5:9542.  [Content Brief]