Anti-Human/Mouse GRP78 Antibody (C38) 

Anti-Human/Mouse GRP78 Antibody (C38) is a kind of mouse IgG2b antibody inhibitor, targeting to GRP78. Anti-Human/Mouse GRP78 Antibody (C38) inhibits RhoA, ROCK and AKT activation. Anti-Human/Mouse GRP78 Antibody (C38) can be used for the researches of cancer and metabolic disease, such as melanoma and diabetes^[1][2].

Mouse IgG2b kappa

Mouse IgG2b kappa, Isotype Control

Human/Mouse

GRP78

Anti-Human/Mouse GRP78 Antibody (C38) (2 μg) inhibits high glucose-induced RhoA and ROCK activation in mesangial cells^[1].
Anti-Human/Mouse GRP78 Antibody (C38) (30 mins) completely abrogates Akt activation in B16F1 melanoma cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Human/Mouse GRP78 Antibody (C38) (200 μg at an initial dose and 100 µg weekly for 12 weeks, i.p.) Attenuated RhoA activation in diabetic kidneys in type 1 diabetes mice models ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

14828  [NCBI]

P20029

in vivo GRP78 targeting; in vitro GRP78 targeting; Flow cytometry

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

150 kDa

Liquid

Colorless to light yellow

[Anti-Human/Mouse GRP78 Antibody (C38)]

Please refer to the lot-specific COA for specific buffer information.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Soomro A, et al. Activin A and Cell-Surface GRP78 Are Novel Targetable RhoA Activators for Diabetic Kidney Disease. Int J Mol Sci. 2021 Mar 11;22(6):2839.  [Content Brief]

  [2]. de Ridder GG, et al. A murine monoclonal antibody directed against the carboxyl-terminal domain of GRP78 suppresses melanoma growth in mice. Melanoma Res. 2012 Jun;22(3):225-35.  [Content Brief]