2. Immunology/Inflammation Anti-infection
  3. STING HSV
  4. Astin C

Astin C (Asterin) is a cyclopeptide that can be extracted from Aster tataricus. Astin C has anti-inflammatory and anti-cancer activities. Astin C can specifically inhibit the cGAS-STING signaling pathway, block the recruitment of IRF3 to the STING signalosome, and thus inhibit the innate inflammatory response. Astin C can be used in the research of autoimmune diseases and cancers.

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Astin C

Astin C 構造式

CAS 番号 : 148057-23-2

容量 価格（税別） 在庫状況 数量
1 mg $175 在庫あり
5 mg $350 在庫あり
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50 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Astin C 関連抗体

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HSV アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
HSV-1 HSV-2 HSV

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製品説明

Astin C (Asterin) is a cyclopeptide that can be extracted from Aster tataricus. Astin C has anti-inflammatory and anti-cancer activities. Astin C can specifically inhibit the cGAS-STING signaling pathway, block the recruitment of IRF3 to the STING signalosome, and thus inhibit the innate inflammatory response. Astin C can be used in the research of autoimmune diseases and cancers[1][2][3].

体外実験

Astin C (10 μM; 6 h) significantly inhibits the expression of Ifnb mRNA induced by cGAS or STING in HEK293 cells[1].
Astin C (10 μM; 6 h) significantly impaires the interactions between STING and IRF3, as well as between STING and SCAP, and inhibits the aggregation of SCAP and IRF3 in HEK293T cells and MEFs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Astin C 関連抗体

Real Time qPCR[1]

Cell Line: HEK293 treated cGAS or STING
Concentration: 10 μM
Incubation Time: 6 h
Result: Inhibited the mRNA level of Ifnb.
体内実験

Astin C (2-4 mg/kg; tail vein injection; once every 2 days; 7 days) can make C57BL/6 mice more susceptible to HSV-1 infection. Additionally, in the autoimmune disease model of Trex1-/- mice, it exhibits anti-inflammatory activity[1].
Astin C (5.0 mg/kg; intraperitoneal injection; 5 days) achieves a tumor growth inhibition rate of 45% in male ICR mice inoculated with Sarcoma 180 ascites tumor[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Trex1-/- mice[1]
Dosage: 2 and 4 mg/kg
Administration: Tail vein injection; once every 2 days; 7 days
Result: Inhibited the expression of type I interferon and pro-inflammatory cytokines in Trex1-/- BMDMs.
Alleviated autoimmune inflammatory symptoms, decreased the abundance of sera autoantibodies, and reduced the percentage of activated CD8+ T cells in the spleen.
分子量

570.47

分子式

C25H33Cl2N5O6
CAS 番号
Appearance

Solid

Color

Off-white to yellow

Sequence

Cyclo({Abu}-Pro-{Abu}-Ser-{Oaa})
Sequence Shortening

Cyclo({Abu}-P-{Abu}-S-{Oaa})
Structure Classification
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Sealed storage, away from moisture
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 100 mg/mL (175.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7529 mL 8.7647 mL 17.5294 mL
5 mM 0.3506 mL 1.7529 mL 3.5059 mL
10 mM 0.1753 mL 0.8765 mL 1.7529 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

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In Vivo Dissolution Calculator
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純度とドキュメンテーション

純度: 99.47%

COA (257 KB) HNMR (346 KB) LCMS (95 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7529 mL 8.7647 mL 17.5294 mL 43.8235 mL
5 mM 0.3506 mL 1.7529 mL 3.5059 mL 8.7647 mL
10 mM 0.1753 mL 0.8765 mL 1.7529 mL 4.3824 mL
15 mM 0.1169 mL 0.5843 mL 1.1686 mL 2.9216 mL
20 mM 0.0876 mL 0.4382 mL 0.8765 mL 2.1912 mL
25 mM 0.0701 mL 0.3506 mL 0.7012 mL 1.7529 mL
30 mM 0.0584 mL 0.2922 mL 0.5843 mL 1.4608 mL
40 mM 0.0438 mL 0.2191 mL 0.4382 mL 1.0956 mL
50 mM 0.0351 mL 0.1753 mL 0.3506 mL 0.8765 mL
60 mM 0.0292 mL 0.1461 mL 0.2922 mL 0.7304 mL
80 mM 0.0219 mL 0.1096 mL 0.2191 mL 0.5478 mL
100 mM 0.0175 mL 0.0876 mL 0.1753 mL 0.4382 mL
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Astin C Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Astin C148057-23-2AsterinSTINGHSVStimulator of Interferon GenesTMEM173MITAERISMPYSHerpes simplex virusnonribosomal peptideTrex1-/- miceHEK293TMEFsInhibitorinhibitorinhibit

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製品名:
Astin C
製品番号:
HY-P1680
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