148057-23-2
Chemical Structure
Astin C
Synonym(s): Asterin
- CAS No.: 148057-23-2
- Formula:C25H33Cl2N5O6
- Molecular Weight:570.47
IUPAC Name: (3R,6S,9R,13S,17R,18S,18aR)-17,18-dichloro-3,13-diethyl-6-(hydroxymethyl)-9-phenyldodecahydropyrrolo[1,2-d][1,4,7,10,13]pentaazacyclohexadecine-1,4,7,11,14(8H)-pentaone
InChIKey: YWGAKIGNXGAAQR-BPOVIGQYSA-N
SMILES: O=C(C[C@H](C1=CC=CC=C1)NC([C@H](CO)NC([C@@H](CC)N2)=O)=O)N[C@@H](CC)C(N3[C@]([C@H](Cl)[C@H](Cl)C3)([H])C2=O)=O
Biological Activity: Astin C (Asterin) is a cyclopeptide that can be extracted from Aster tataricus. Astin C has anti-inflammatory and anti-cancer activities. Astin C can specifically inhibit the cGAS-STING signaling pathway, block the recruitment of IRF3 to the STING signalosome, and thus inhibit the innate inflammatory response. Astin C can be used in the research of autoimmune diseases and cancers[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Astin C | 99.47% | Astin C (Asterin) is a cyclopeptide that can be extracted from Aster tataricus. Astin C has anti-inflammatory and anti-cancer activities. Astin C can specifically inhibit the cGAS-STING signaling pathway, block the recruitment of IRF3 to the STING signalosome, and thus inhibit the innate inflammatory response. Astin C can be used in the research of autoimmune diseases and cancers. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
- [1]. Li S, et al. The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING. Cell Rep. 2018 Dec 18;25(12):3405-3421.e7. [Content Brief]
- [2]. Antoine Vassaux, et al. Astin C Production by the Endophytic Fungus Cyanodermella asteris in Planktonic and Immobilized Culture Conditions. Biotechnol J. 2019 Aug;14(8):e1800624. [Content Brief]
- [3]. Morita H, et al. Cyclic peptides from higher plants. XXVIII. Antitumor activity and hepatic microsomal biotransformation of cyclic pentapeptides, astins, from Aster tataricus. Chem Pharm Bull (Tokyo). 1996 May;44(5):1026-32. [Content Brief]
Keywords
