1-Alaninechlamydocin
1-Alaninechlamydocin, a cyclic tetrapeptide, is a potent HDAC inhibitor (IC50=6.4 nM). 1-Alaninechlamydocin induces G2/M cell cycle arrest and apoptosis in MIA PaCa-2 cells.
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- CAS No.: 141446-96-0
- Formule: C27H36N4O6
- Masse moléculaire:512.60
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Activité biologique
Description
IC50 & Target
[1]|
HDAC 6.4 nM (IC50) |
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
6.4 nM
Compound: 1
|
Inhibition of HDAC in human HeLa cell lysates after 30 mins by fluorescence based assay
Inhibition of HDAC in human HeLa cell lysates after 30 mins by fluorescence based assay
|
[PMID: 24999749] |
| MIA PaCa-2 | GI50 |
5.3 nM
Compound: 1
|
Antiproliferative activity against human MIAPaCa2 cells after 48 hrs by MTT assay
Antiproliferative activity against human MIAPaCa2 cells after 48 hrs by MTT assay
|
[PMID: 24999749] |
| PANC-1 | GI50 |
14 nM
Compound: 1
|
Antiproliferative activity against human PANC1 cells after 48 hrs by MTT assay
Antiproliferative activity against human PANC1 cells after 48 hrs by MTT assay
|
[PMID: 24999749] |
Chemical Information
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CAS No. 141446-96-0
-
Masse moléculaire 512.60
-
Formule C27H36N4O6
-
Structure Classification
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Initial Source
Diheterospora chlamydosporia
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)