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Cat. No.: HY-111413

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c(phg-isoDGR-(NMe)k)

c(phg-isoDGR-(NMe)k) is a selective and potent α5β1-integrin ligand with an IC₅₀ of 2.9 nM.

For research use only. We do not sell to patients.

CAS No.: 1844830-65-4
Formula: C₂₇H₄₁N₉O₇
Molecular Weight:603.67

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

c(phg-isoDGR-(NMe)k) Chemical Structure

CAS No.: 1844830-65-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

c(phg-isoDGR-(NMe)k) is a selective and potent α5β1-integrin ligand with an IC₅₀ of 2.9 nM^[1].

IC₅₀ & Target

IC50: 2.9 nM (α5β1)^[1]

All Integrin Isoforms :

In Vivo

c(phg-isoDGR-(NMe)k) is trimerized with the chelator TRAP and used as a positron-emission tomography tracer for monitoring α5β1 integrin expression in a M21 mouse xenograft^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1844830-65-4
Molecular Weight 603.67
Formula C₂₇H₄₁N₉O₇
SMILES

O=C(CNC(C[C@@H](C(O)=O)NC([C@@H](C1=CC=CC=C1)NC([C@H]2CCCCN)=O)=O)=O)N[C@@H](CCCNC(N)=N)C(N2C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kapp TG, et al. N-Methylation of isoDGR Peptides: Discovery of a Selective α5β1-Integrin Ligand as a Potent Tumor Imaging Agent. J Med Chem. 2018 Mar 22;61(6):2490-2499. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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