Cholesterol 24-hydroxylase-IN-1

Art. -Nr.: HY-144309 Reinheit: 99.55%: Data Sheet
COA

SDS
Handling Instructions
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Technical Support

Cholesterol 24-hydroxylase-IN-1 (compound 17) is a potent, orally active, and highly selective cholesterol 24-hydroxylase (CH24H or CYP46A1) inhibitor (IC₅₀=8.5 nM). Cholesterol 24-hydroxylase-IN-1 can cross blood-brain barrier.

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Cholesterol 24-hydroxylase-IN-1 Chemische Struktur

CAS. Nr. : 1613480-70-8

Größe	Verfügbarkeit	Menge

Kostenlose Probe (0.1 - 0.2 mg)	Jetzt bewerben
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	Auf Lager	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	Auf Lager	Estimated Time of Arrival: December 31
Solid
5 mg	Auf Lager	Estimated Time of Arrival: December 31
10 mg	Auf Lager	Estimated Time of Arrival: December 31
25 mg	Auf Lager	Estimated Time of Arrival: December 31
50 mg	Auf Lager	Estimated Time of Arrival: December 31
100 mg	Auf Lager	Estimated Time of Arrival: December 31
200 mg	Angebot einholen
500 mg	Angebot einholen

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Spezialitätsempfehlungen

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Alle Cytochrome P450 Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen

CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A CYP3A4 CYP17A1

Biologische Aktivität
Reinheit & Dokumentation
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Beschreibung

Molekulargewicht

313.40

Formel

C₁₇H₂₃N₅O

CAS. Nr.

1613480-70-8

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1CCN(C2=C(N3N=CC(C)=C3)C=CN=C2)CC1)N(C)C

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (319.08 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1908 mL	15.9541 mL	31.9081 mL
5 mM	0.6382 mL	3.1908 mL	6.3816 mL
10 mM	0.3191 mL	1.5954 mL	3.1908 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner
Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Reinheit & Dokumentation

Purity: 99.55%

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Data Sheet (271 KB) SDS (251 KB)

COA (252 KB) HNMR (174 KB) LCMS (102 KB)

Handling Instructions (2659 KB)

Verweise

[1]. Kajita Y, et al. Discovery of Novel 3-Piperidinyl Pyridine Derivatives as Highly Potent and Selective Cholesterol 24-Hydroxylase (CH24H) Inhibitors. J Med Chem. 2022;65(4):3343-3358. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.1908 mL	15.9541 mL	31.9081 mL	79.7703 mL
	5 mM	0.6382 mL	3.1908 mL	6.3816 mL	15.9541 mL
	10 mM	0.3191 mL	1.5954 mL	3.1908 mL	7.9770 mL
	15 mM	0.2127 mL	1.0636 mL	2.1272 mL	5.3180 mL
	20 mM	0.1595 mL	0.7977 mL	1.5954 mL	3.9885 mL
	25 mM	0.1276 mL	0.6382 mL	1.2763 mL	3.1908 mL
	30 mM	0.1064 mL	0.5318 mL	1.0636 mL	2.6590 mL
	40 mM	0.0798 mL	0.3989 mL	0.7977 mL	1.9943 mL
	50 mM	0.0638 mL	0.3191 mL	0.6382 mL	1.5954 mL
	60 mM	0.0532 mL	0.2659 mL	0.5318 mL	1.3295 mL
	80 mM	0.0399 mL	0.1994 mL	0.3989 mL	0.9971 mL
	100 mM	0.0319 mL	0.1595 mL	0.3191 mL	0.7977 mL