2. Cytoskeleton Apoptosis
  3. Integrin Apoptosis
  4. Cyclo(Arg-Gly-Asp-D-Phe-Val)

Cyclo(Arg-Gly-Asp-D-Phe-Val)  (Synonyms: Cyclo(RGDfV); C(RGDfV))

製品番号: HY-P1613
取扱説明書 Technical Support

Cyclo(Arg-Gly-Asp-D-Phe-Val) (Cyclo(RGDfV)) is an integrin αvβ3 inhibitor. Cyclo(Arg-Gly-Asp-D-Phe-Val) has antitumor activity. Cyclo(Arg-Gly-Asp-D-Phe-Val) can be used for the research of acute myeloid leukemia.

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Cyclo(Arg-Gly-Asp-D-Phe-Val)

Cyclo(Arg-Gly-Asp-D-Phe-Val) 構造式

CAS 番号 : 137813-35-5

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Other 在庫あり Forms of Cyclo(Arg-Gly-Asp-D-Phe-Val):

Other Forms of Cyclo(Arg-Gly-Asp-D-Phe-Val):

Cyclo(Arg-Gly-Asp-D-Phe-Val) 関連抗体

Top Publications Citing Use of Products

Integrin アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

  • 生物活性

  • 純度とドキュメンテーション

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製品説明

Cyclo(Arg-Gly-Asp-D-Phe-Val) (Cyclo(RGDfV)) is an integrin αvβ3 inhibitor. Cyclo(Arg-Gly-Asp-D-Phe-Val) has antitumor activity. Cyclo(Arg-Gly-Asp-D-Phe-Val) can be used for the research of acute myeloid leukemia[1].

IC50 & Target

αvβ3[1]
Cellular Effect
Cell Line Type Value Description References
A549 IC50
3.25 x 10-7 M
Compound: 6, c(RGDfV)
Displacement of [125I]echistatin from human integrin alpha5beta3 expressed in human A549 cells by binding assay
Displacement of [125I]echistatin from human integrin alpha5beta3 expressed in human A549 cells by binding assay
[PMID: 21349709]
HUVEC IC50
0.53 μM
Compound: CycloRGDfV
Inhibition of HUVEC migration after 4 hrs
Inhibition of HUVEC migration after 4 hrs
[PMID: 19081719]
HUVEC IC50
3.1 μM
Compound: CycloRGDfV
Inhibition of FGF-induced HUVEC proliferation after 48 hrs
Inhibition of FGF-induced HUVEC proliferation after 48 hrs
[PMID: 19081719]
HUVEC IC50
4.5 μM
Compound: CycloRGDfV
Inhibition of VEGF-induced HUVEC proliferation after 48 hrs
Inhibition of VEGF-induced HUVEC proliferation after 48 hrs
[PMID: 19081719]
HUVEC IC50
9.6 μM
Compound: c[RGDfV]
Inhibition of alphavbeta3 integrin-mediated cell adhesion in HUVEC on vitronectin coated plate after 30 mins
Inhibition of alphavbeta3 integrin-mediated cell adhesion in HUVEC on vitronectin coated plate after 30 mins
[PMID: 20055426]
K562 IC50
0.68 μM
Compound: c (RGDfV)
Inhibition of adhesion of K562 cells expressing alphaVbeta3 integrin receptor to vitronectin
Inhibition of adhesion of K562 cells expressing alphaVbeta3 integrin receptor to vitronectin
[PMID: 16722662]
K562 IC50
34.7 μM
Compound: c[RGDfV]
Inhibition of alpha5beta1 integrin-mediated cell adhesion in human K562 cells on fibronectin coated plate after 30 mins
Inhibition of alpha5beta1 integrin-mediated cell adhesion in human K562 cells on fibronectin coated plate after 30 mins
[PMID: 20055426]
K562 IC50
34.7 μM
Compound: cyclo-Arg-Gly-Asp-D-Phe-Val
Antagonist activity at alpha5beta1 integrin in human K562 cells assessed as inhibition of fibronectin-mediated cell adhesion after 30 mins by fluorescence assay
Antagonist activity at alpha5beta1 integrin in human K562 cells assessed as inhibition of fibronectin-mediated cell adhesion after 30 mins by fluorescence assay
[PMID: 24973662]
M21 IC50
0.6 μM
Compound: c (RGDfV)
Inhibition of integrin alphavbeta3 mediated cell adhesion of human M21 cells to vitronectin
Inhibition of integrin alphavbeta3 mediated cell adhesion of human M21 cells to vitronectin
[PMID: 16982193]
WM-115 IC50
0.5 μM
Compound: c-(-Arg-Gly-Asp-D-Phe-Val-)
Binding affinity to integrin in human WM-115 cells after 30 mins by immobilized vitronectin-based competitive cell adhesion assay
Binding affinity to integrin in human WM-115 cells after 30 mins by immobilized vitronectin-based competitive cell adhesion assay
[PMID: 23387527]
体外実験

Cyclo(Arg-Gly-Asp-d-Phe-Val) (Cyclo(RGDfV)) (35 nM, 4-24 h) disruptes the adhesion and migration between the tumor cells and the matrix, induces the leukemia cells to leave the protective microenvironment and increases their sensitivity to cell cycle-dependent agents[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cyclo(Arg-Gly-Asp-D-Phe-Val) 関連抗体

Cell Cycle Analysis[1]

Cell Line: MV4–11 cells
Concentration: 35 nM
Incubation Time: 24 h
Result: Affected the leukemia cell cycle, decreased the G0/G1 phase of leukemia cells in the 3D and 2D culture systems and increased the S phase of leukemia cells in the 3D and 2D culture systems.

Apoptosis Analysis[1]

Cell Line: MV4–11 cells
Concentration: 35 nM
Incubation Time: 24 h
Result: Increased the apoptosis rates.
分子量

574.63

分子式

C26H38N8O7
CAS 番号
Sequence Shortening

Cyclo(RGD-{d-Phe}-V)
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
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Cyclo(Arg-Gly-Asp-D-Phe-Val) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cyclo(Arg-Gly-Asp-D-Phe-Val)137813-35-5Cyclo(RGDfV)C(RGDfV)IntegrinApoptosisintegrin αvβ3antitumoracute myeloid leukemiacancerInhibitorinhibitorinhibit

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製品名:
Cyclo(Arg-Gly-Asp-D-Phe-Val)
製品番号:
HY-P1613
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