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  3. Cyclo(Arg-Gly-Asp-D-Phe-Val) TFA

Cyclo(Arg-Gly-Asp-D-Phe-Val) TFA 

Cat. No.: HY-P1613A Purity: 99.40%
Handling Instructions

Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) is an inhibitor of integrin αvβ3, with antitumor activity.

For research use only. We do not sell to patients.

Cyclo(Arg-Gly-Asp-D-Phe-Val) TFA Chemical Structure

Cyclo(Arg-Gly-Asp-D-Phe-Val) TFA Chemical Structure

CAS No. : 199807-33-5

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1 mg USD 120 In-stock
Estimated Time of Arrival: December 31
5 mg USD 380 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) is an inhibitor of integrin αvβ3, with antitumor activity.

IC50 & Target

αvβ3[1]

In Vitro

Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) is an inhibitor of integrin αvβ3. Cyclo(Arg-Gly-Asp-D-Phe-Val) [c(RGDfV); 35 nM] induces disruption of leukemia cell migration and adhesion to leukemia osteoblasts in the 3D and 2D culture systems, affects the leukemia cell cycle and induces apoptosis in leukemia cells[1].

Molecular Weight

688.65

Formula

C₂₈H₃₉F₃N₈O₉

CAS No.

199807-33-5

Sequence

Cyclo(Arg-Gly-Asp-{d-Phe}-Val)

Sequence Shortening

Cyclo(RGD-{d-Phe}-V)

SMILES

O=C([[email protected]@H](NC(CNC([[email protected]](CCCNC(N)=N)NC([[email protected]](C(C)C)NC1=O)=O)=O)=O)CC(O)=O)N[[email protected]@H]1CC2=CC=CC=C2.FC(C(O)=O)(F)F

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
References
Cell Assay
[1]

The osteoblasts are cultured in RPMI 1640 medium for 2 days. MV4-11 cells (1.8×105 cells/mL in the 2D culture system and 1×106 cells/mL in the 3D culture system) are co-cultured with leukemia osteoblasts in RPMI 1640 medium. The experiments used two groups: The experimental group received c(RGDfV) (35 nmol/mL) and the control group received an equal volume of phosphate-buffered saline (PBS) only[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Cyclo(Arg-Gly-Asp-D-Phe-Val) TFA
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