DM-1157

DM-1157 (Compound 22) (0.9-1.8 nM; 72 h) potently inhibits growth of chloroquine-sensitive D6, chloroquine-resistant Dd2, and chloroquine-resistant 7G8 Plasmodium falciparum strains in vitro with normalized IC₅₀ values of 0.9 nM, 1.6 nM, and 1.8 nM, respectively^[1].
DM-1157 (6500 nM) has a low in vitro cytotoxicity against murine spleenic lymphocytes, with a cytotoxicity IC₅₀ of 6500 nM and a therapeutic index of 4060 relative to its antimalarial activity against Dd2 Plasmodium falciparum^[1].
DM-1157 (10-50 nM; 24 h) potently inhibits hemozoin production in synchronized chloroquine-sensitive D6 and chloroquine-resistant Dd2 Plasmodium falciparum strains in vitro, with near-complete inhibition at 10 nM and complete inhibition at 50 nM, while inducing digestive vacuole enlargement^[1].
DM-1157 (72 h) potently inhibits in vitro growth of chloroquine-sensitive P. falciparum D6 (IC₅₀ = 0.2 nM) and chloroquine-resistant P. falciparum Dd2 (IC₅₀ = 2.2 nM) and 7G8 (IC₅₀ = 1.8 nM) strains, and shows cytotoxicity against mouse spleen lymphocytes with an LC₅₀ of 6500 nM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.