Fluphenazine decanoate

Name: Fluphenazine decanoate
Brand: MedChemExpress
SKU: HY-B1904
Rating: 4.5 (0 reviews)

Cat. No.: HY-B1904 Purity: 98.75%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Fluphenazine decanoate is a CNS-penetrant dopamine D₂ receptor inhibitor, is a long-acting phenothiazine neuroleptic. Fluphenazine can be used for schizophrenia research.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Fluphenazine decanoate 화학구조

CAS No. : 5002-47-1

사이즈	재고	수량
Solid or liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Solid or liquid
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
200 mg	견적 받기
500 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

Other Forms of Fluphenazine decanoate:

Fluphenazine dihydrochloride In-stock
Fluphenazine decanoate dihydrochloride 견적 받기
Fluphenazine decanoate (Standard) 견적 받기

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Dopamine Receptor Isoform Specific Products:

View All Isoforms

Dopamine Receptor D₁ Receptor D₂ Receptor D₃ Receptor D₄ Receptor D₅ Receptor

Biological Activity
순도&문서
References
고객리뷰

제품 설명

Fluphenazine decanoate is a CNS-penetrant dopamine D₂ receptor inhibitor, is a long-acting phenothiazine neuroleptic. Fluphenazine can be used for schizophrenia research^[1]^[2]^[3].

IC₅₀ & Target

D₂ Receptor

In Vitro

Fluphenazine decanoate shows activity against T. gondii in human fibroblast cell cultures with an IC₅₀ value of 1.7 mM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Fluphenazine decanoate (0.22 mg/kg and followed by 0.33 mg/kg; i.m.; 8 times every 3 weeks), as an antipsychotic, increases sensitivity to dopamine on monkey model following extended treatment^[2].
Fluphenazine decanoate (25 mg/kg; i.m.; 6 times every 3 weeks; 24 weeks) induces mouth movements in the rat, serves as a pharmacological model of human tardive dyskinesia^[3].
Fluphenazine decanoate (1, 2, 3 mg/kg/d; s.c.; 60 d) shows antifertility effects and induces hyperprolactinemia concomitant with gonadotropin suppression in adult male rat^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Cebus apella monkey^[2]
Dosage:	0.22 mg/kg and followed by 0.33 mg/kg
Administration:	Intramuscular injection; 8 times per 3 weeks; 0.22 mg/kg for 63 weeks and 0.33 mg/kg for 6 weeks
Result:	Decreased the aggressiveness composite behavioral variables (CBV). Resulted stereotypic behavior induced by agonist and decreased prolactin response to AMPH.

Animal Model:	Male Sprague-Dawley rats (250 g)^[3]
Dosage:	25 mg/kg
Administration:	Intramuscular injection into the hind limb; 24 weeks
Result:	Resulted in spontaneous vacuous chewing mouth movements and jaw tremor.

Animal Model:	Adult male rats^[4]
Dosage:	1, 2, 3 mg/kg/d
Administration:	Subcutaneous injection between 10:00-12:00 h; 60 days
Result:	Increased serum prolactin level and suppressed serum LH and FSH levels at day 60. Increased hypothalamic tyrosine hydroxylase levels, enhanced chromatin decondensation, and resulted DNA denaturation.

분자량

591.77

화학식

C₃₂H₄₄F₃N₃O₂S

CAS No.

5002-47-1

Appearance

<30°C Solid,>32°C Liquid

Color

Light yellow to yellow

SMILES

CCCCCCCCCC(OCCN1CCN(CCCN2C3=C(C=CC=C3)SC4=CC=C(C(F)(F)F)C=C24)CC1)=O

선적

Room temperature in continental US; may vary elsewhere.

보관

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

DMSO : 125 mg/mL (211.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : 50 mg/mL (84.49 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6898 mL	8.4492 mL	16.8985 mL
5 mM	0.3380 mL	1.6898 mL	3.3797 mL
10 mM	0.1690 mL	0.8449 mL	1.6898 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1.08 mg/mL (1.83 mM); Clear solution

This protocol yields a clear solution of ≥ 1.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (10.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 1.08 mg/mL (1.83 mM); Clear solution

This protocol yields a clear solution of ≥ 1.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (10.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 1.08 mg/mL (1.83 mM); Clear solution

This protocol yields a clear solution of ≥ 1.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (10.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

순도&문서

Purity: 98.75%

Select Batch:

Data Sheet (273 KB) SDS (644 KB)

COA (243 KB) HNMR (118 KB) LCMS (138 KB)

Handling Instructions (2659 KB)

References

[1]. Goodwin DG, et al. Evaluation of five antischizophrenic agents against Toxoplasma gondii in human cell cultures. J Parasitol. 2011 Feb;97(1):148-51. [Content Brief]

[2]. Lifshitz K, et al. Effects of dopamine agonists on Cebus apella monkeys with previous long-term exposure to fluphenazine. Biol Psychiatry. 1997 Mar 15;41(6):657-67. [Content Brief]

[3]. Stoessl AJ, et al. Chronic neuroleptic-induced mouth movements in the rat: suppression by CCK and selective dopamine D1 and D2 receptor antagonists. Psychopharmacology (Berl). 1989;98(3):372-9. [Content Brief]

[4]. Gill-Sharma MK, et al. Antifertility effects of fluphenazine in adult male rats. J Endocrinol Invest. 2003 Apr;26(4):316-26. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

Ethanol / DMSO	1 mM	1.6898 mL	8.4492 mL	16.8985 mL	42.2461 mL
	5 mM	0.3380 mL	1.6898 mL	3.3797 mL	8.4492 mL
	10 mM	0.1690 mL	0.8449 mL	1.6898 mL	4.2246 mL
	15 mM	0.1127 mL	0.5633 mL	1.1266 mL	2.8164 mL
	20 mM	0.0845 mL	0.4225 mL	0.8449 mL	2.1123 mL
	25 mM	0.0676 mL	0.3380 mL	0.6759 mL	1.6898 mL
	30 mM	0.0563 mL	0.2816 mL	0.5633 mL	1.4082 mL
	40 mM	0.0422 mL	0.2112 mL	0.4225 mL	1.0562 mL
	50 mM	0.0338 mL	0.1690 mL	0.3380 mL	0.8449 mL
	60 mM	0.0282 mL	0.1408 mL	0.2816 mL	0.7041 mL
	80 mM	0.0211 mL	0.1056 mL	0.2112 mL	0.5281 mL
DMSO	100 mM	0.0169 mL	0.0845 mL	0.1690 mL	0.4225 mL