Foscarnet sodium (Synonyms: Trisodium phosphonoformate; Phosphonoformic acid trisodium salt)

Name: Foscarnet sodium
Brand: MedChemExpress
SKU: HY-B1318
Rating: 5.0 (3 reviews)

Cat. No.: HY-B1318 Purity: 98.0%: Data Sheet
COA

SDS
Handling Instructions
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Foscarnet sodium (Trisodium phosphonoformate) is a viral DNA polymerase activity inhibitor, leading to reversible suppression of viral replication. Foscarnet sodium is an antiherpesvirus agent used in cytomegalovirus retinitis.

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Foscarnet sodium 화학구조

CAS No. : 63585-09-1

사이즈	재고	수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	해외재고보유	Estimated Time of Arrival: December 31
Solid
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
200 mg	견적 받기
500 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 3 publication(s) in Google Scholar

Other Forms of Foscarnet sodium:

Foscarnet trisodium hexahydrate In-stock
Foscarnet sodium (Standard) 견적 받기

3 Publications Citing Use of MCE Foscarnet sodium

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•Related Screening Libraries:

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View All DNA/RNA Synthesis Isoform Specific Products:

View All Isoforms

RNASE L DNA Polymerases RNA Polymerases Helicases DNA Ligase

Biological Activity
순도&문서
References
고객리뷰

제품 설명

IC₅₀ & Target

DNA Polymerase

Cellular Effect

Cell Line	Type	Value	Description	References
HEL	IC₅₀	15.5 3 Compound: phosphonoformate	Inhibition of human CMV DNA synthesis in CMV-infected HEL cells. Inhibition of human CMV DNA synthesis in CMV-infected HEL cells.	[PMID: 7752205]
HFF	IC₅₀	>100 3 Compound: Foscarnet sodium	Compound was evaluated for the visual cytotoxicity scored on HFF cells at time of HCMV plaque enumeration Compound was evaluated for the visual cytotoxicity scored on HFF cells at time of HCMV plaque enumeration	[PMID: 7562945]
Vero	ED₅₀	230 3 Compound: Foscarnet sodium	Compound was tested for antiviral activity against Herpes simplex virus type 1 (HF) Compound was tested for antiviral activity against Herpes simplex virus type 1 (HF)	[PMID: 3016264]
Vero	ED₅₀	170 3 Compound: Foscarnet sodium	Compound was tested for antiviral activity against Herpes simplex virus type 1(KOS) Compound was tested for antiviral activity against Herpes simplex virus type 1(KOS)	[PMID: 3016264]
HEL	IC₅₀	15.5 3 Compound: phosphonoformate	Inhibition of human CMV DNA synthesis in CMV-infected HEL cells. Inhibition of human CMV DNA synthesis in CMV-infected HEL cells.	[PMID: 7752205]
Vero	ED₅₀	89 3 Compound: Foscarnet sodium	Compound was tested for antiviral activity against Herpes simplex virus type 2 (MS) Compound was tested for antiviral activity against Herpes simplex virus type 2 (MS)	[PMID: 3016264]
Vero	ED₅₀	20 3 Compound: Foscarnet sodium	Compound was tested for antiviral activity against Herpes simplex virus type 2 of strain 333 Compound was tested for antiviral activity against Herpes simplex virus type 2 of strain 333	[PMID: 3016264]
HFF	IC₅₀	> 100 3 Compound: Foscarnet sodium	Compound was evaluated for the visual cytotoxicity scored on HFF cells at time of HCMV plaque enumeration Compound was evaluated for the visual cytotoxicity scored on HFF cells at time of HCMV plaque enumeration	[PMID: 7562945]
Vero	ED₅₀	>5 2 Compound: Foscarnet sodium	Compound was tested for antiviral activity against measles virus Compound was tested for antiviral activity against measles virus	[PMID: 3016264]
Vero	ED₅₀	170 3 Compound: Foscarnet sodium	Compound was tested for antiviral activity against Herpes simplex virus type 1(KOS) Compound was tested for antiviral activity against Herpes simplex virus type 1(KOS)	[PMID: 3016264]
Vero	ED₅₀	5 2 Compound: Foscarnet sodium	Compound was tested for antiviral activity against para 3 Compound was tested for antiviral activity against para 3	[PMID: 3016264]
Vero	ED₅₀	20 3 Compound: Foscarnet sodium	Compound was tested for antiviral activity against Herpes simplex virus type 2 of strain 333 Compound was tested for antiviral activity against Herpes simplex virus type 2 of strain 333	[PMID: 3016264]
Vero	ED₅₀	230 3 Compound: Foscarnet sodium	Compound was tested for antiviral activity against Herpes simplex virus type 1 (HF) Compound was tested for antiviral activity against Herpes simplex virus type 1 (HF)	[PMID: 3016264]
Vero	ED₅₀	5000 3 Compound: Foscarnet sodium	Compound was tested for antiviral activity against para 3 Compound was tested for antiviral activity against para 3	[PMID: 3016264]
Vero	ED₅₀	89 3 Compound: Foscarnet sodium	Compound was tested for antiviral activity against Herpes simplex virus type 2 (MS) Compound was tested for antiviral activity against Herpes simplex virus type 2 (MS)	[PMID: 3016264]
Vero	ED₅₀	> 5000 3 Compound: Foscarnet sodium	Compound was tested for antiviral activity against measles virus Compound was tested for antiviral activity against measles virus	[PMID: 3016264]
Vero	ED₅₀	> 5000 3 Compound: Foscarnet sodium	Compound was tested for antiviral activity against vaccinia Compound was tested for antiviral activity against vaccinia	[PMID: 3016264]

In Vitro

Foscarnet sodium (Trisodium phosphonoformate) inhibits Influenza A Victoria (IC₅₀=29 μM), Influenza B HK (IC₅₀=61 μM), and Avian myeloblastosis virus (IC₅₀=5-8 μM),HSV-1, several strains (IC₅₀=0.4-3.5 μM)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

191.95

화학식

CNa₃O₅P

CAS No.

63585-09-1

Appearance

Solid

Color

White to off-white

SMILES

O=P(O[Na])(O[Na])C(O[Na])=O

선적

Room temperature in continental US; may vary elsewhere.

보관

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

용액&용해도

In Vitro:

H₂O : 16.67 mg/mL (86.85 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.2097 mL	26.0485 mL	52.0969 mL
5 mM	1.0419 mL	5.2097 mL	10.4194 mL
10 mM	0.5210 mL	2.6048 mL	5.2097 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

순도&문서

Purity: 98.0%

Select Batch:

Data Sheet (277 KB) SDS (393 KB)

COA (253 KB) CNMR (255 KB)

Handling Instructions (2659 KB)

References

[1]. Manischewitz JF, et al. Synergistic effect of ganciclovir and foscarnet on cytomegalovirus replication in vitro.Antimicrob Agents Chemother. 1990 Feb;34(2):373-5. [Content Brief]

[2]. Oberg B, et al. Antiviral effects of phosphonoformate (PFA, foscarnet sodium).Pharmacol Ther. 1982;19(3):387-415. [Content Brief]

[3]. Hakki M, et al. Moving Past Ganciclovir and Foscarnet: Advances in CMV Therapy.Curr Hematol Malig Rep. 2020 Jan 24. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	5.2097 mL	26.0485 mL	52.0969 mL	130.2423 mL
	5 mM	1.0419 mL	5.2097 mL	10.4194 mL	26.0485 mL
	10 mM	0.5210 mL	2.6048 mL	5.2097 mL	13.0242 mL
	15 mM	0.3473 mL	1.7366 mL	3.4731 mL	8.6828 mL
	20 mM	0.2605 mL	1.3024 mL	2.6048 mL	6.5121 mL
	25 mM	0.2084 mL	1.0419 mL	2.0839 mL	5.2097 mL
	30 mM	0.1737 mL	0.8683 mL	1.7366 mL	4.3414 mL
	40 mM	0.1302 mL	0.6512 mL	1.3024 mL	3.2561 mL
	50 mM	0.1042 mL	0.5210 mL	1.0419 mL	2.6048 mL
	60 mM	0.0868 mL	0.4341 mL	0.8683 mL	2.1707 mL
	80 mM	0.0651 mL	0.3256 mL	0.6512 mL	1.6280 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Foscarnet sodium Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Foscarnet63585-09-1Trisodium phosphonoformate Phosphonoformic acid trisodiumDNA/RNA SynthesisviralDNApolymerasereversiblesuppressionreplicationantiherpesviruscytomegalovirusretinitisInhibitorinhibitorinhibit

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Foscarnet sodium (Synonyms: Trisodium phosphonoformate; Phosphonoformic acid trisodium salt)

고객리뷰

Other Forms of Foscarnet sodium:

Foscarnet sodium Related Antibodies

3 Publications Citing Use of MCE Foscarnet sodium

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All DNA/RNA Synthesis Isoform Specific Products:

Biological Activity

순도&문서

References

고객리뷰

Foscarnet sodium Related Antibodies

몰농도 계산기

농도 희석 계산기

Complete Stock Solution Preparation Table

Foscarnet sodium Related Classifications

Keywords:

최근 본 상품:

고객리뷰

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report