Foscarnet trisodium hexahydrate
Based on 3 publication(s) in Google Scholar
Foscarnet trisodium hexahydrate (Trisodium phosphonatoformate hexahydrate) is a viral DNA polymerase activity inhibitor, leading to reversible suppression of viral replication. Foscarnet trisodium hexahydrate is an antiherpesvirus agent used in cytomegalovirus retinitis.
For research use only. We do not sell to patients.
- Purity: 99.50%
- CAS No.: 34156-56-4
- Formula: CH12Na3O11P
- Molecular Weight:300.04
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Foscarnet trisodium hexahydrate
MoreAll DNA/RNA Synthesis Isoforms
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Biological Activity
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DNA Polymerase |
Foscarnet sodium (Phosphonoformic acid) inhibit the human cytomegalovirus DNA polymerase (UL54) by mimicking the pyrophosphate leaving group of the nucleotide transfer reaction[1].
Foscarnet sodium (Trisodium phosphonoformate) inhibits Influenza A Victoria (IC50=29 μM), Influenza B HK (IC50=61 μM), and Avian myeloblastosis virus (IC50=5-8 μM), HSV-1, several strains (IC50=0.4-3.5 μM)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 34156-56-4
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Appearance Solid
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Molecular Weight 300.04
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Formula CH12Na3O11P
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Color White to off-white
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SMILES
O=C(P(O[Na])(O[Na])=O)O[Na].[6H2O]
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Synonyms
Trisodium phosphonoformate hexahydrate; Phosphonoformic acid trisodium salt hexahydrate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (3)
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Journal Impact Factor
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Most Recent
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Antiviral Res
Generation of a panel of mutants that are resistant to standard of care therapies in a clinically relevant strain of human cytomegalovirus for drug resistance profiling. [Abstract]2025 Sep:241:106237. PMID: 40653174 -
Viruses
Role of PARP-1 in Human Cytomegalovirus Infection and Functional Partners Encoded by This Virus. [Abstract]2022 Sep 15;14(9):2049. PMID: 36146855 -
J Med Virol
2023 Jan;95(1):e28352. PMID: 36437481
Solvent & Solubility
H2O : 50 mg/mL (166.64 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (280 KB)
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SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
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Handling Instructions (2659 KB)
References
[1]. Zahn KE, Doublié S, et al. Phosphonoformic acid inhibits viral replication by trapping the closed form of the DNA polymerase. J Biol Chem. 2011 Jul 15;286(28):25246-55. [Content Brief]
[2]. Oberg B, et al. Antiviral effects of phosphonoformate (PFA, foscarnet sodium).Pharmacol Ther. 1982;19(3):387-415. [Content Brief]
[3]. Hakki M, et al. Moving Past Ganciclovir and Foscarnet: Advances in CMV Therapy.Curr Hematol Malig Rep. 2020 Jan 24. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 3.3329 mL | 16.6644 mL | 33.3289 mL | 83.3222 mL |
| 5 mM | 0.6666 mL | 3.3329 mL | 6.6658 mL | 16.6644 mL | |
| 10 mM | 0.3333 mL | 1.6664 mL | 3.3329 mL | 8.3322 mL | |
| 15 mM | 0.2222 mL | 1.1110 mL | 2.2219 mL | 5.5548 mL | |
| 20 mM | 0.1666 mL | 0.8332 mL | 1.6664 mL | 4.1661 mL | |
| 25 mM | 0.1333 mL | 0.6666 mL | 1.3332 mL | 3.3329 mL | |
| 30 mM | 0.1111 mL | 0.5555 mL | 1.1110 mL | 2.7774 mL | |
| 40 mM | 0.0833 mL | 0.4166 mL | 0.8332 mL | 2.0831 mL | |
| 50 mM | 0.0667 mL | 0.3333 mL | 0.6666 mL | 1.6664 mL | |
| 60 mM | 0.0555 mL | 0.2777 mL | 0.5555 mL | 1.3887 mL | |
| 80 mM | 0.0417 mL | 0.2083 mL | 0.4166 mL | 1.0415 mL | |
| 100 mM | 0.0333 mL | 0.1666 mL | 0.3333 mL | 0.8332 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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