2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. Foscarnet trisodium hexahydrate

Foscarnet trisodium hexahydrate  (Synonyms: Trisodium phosphonoformate hexahydrate; Phosphonoformic acid trisodium salt hexahydrate)

Cat. No.: HY-W013256 Assay: 99.50%
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Foscarnet trisodium hexahydrate (Trisodium phosphonatoformate hexahydrate) is a viral DNA polymerase activity inhibitor, leading to reversible suppression of viral replication. Foscarnet trisodium hexahydrate is an antiherpesvirus agent used in cytomegalovirus retinitis.

For research use only. We do not sell to patients.

Foscarnet trisodium hexahydrate Chemical Structure

Foscarnet trisodium hexahydrate Chemical Structure

CAS No. : 34156-56-4

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Based on 2 publication(s) in Google Scholar

Other Forms of Foscarnet trisodium hexahydrate:

Foscarnet trisodium hexahydrate Related Antibodies

Top Publications Citing Use of Products

2 Publications Citing Use of MCE Foscarnet trisodium hexahydrate

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  • Purity & Documentation

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Description

Foscarnet trisodium hexahydrate (Trisodium phosphonatoformate hexahydrate) is a viral DNA polymerase activity inhibitor, leading to reversible suppression of viral replication. Foscarnet trisodium hexahydrate is an antiherpesvirus agent used in cytomegalovirus retinitis[1][2][3].

In Vitro

Foscarnet sodium (Phosphonoformic acid) inhibit the human cytomegalovirus DNA polymerase (UL54) by mimicking the pyrophosphate leaving group of the nucleotide transfer reaction[1].
Foscarnet sodium (Trisodium phosphonoformate) inhibits Influenza A Victoria (IC50=29 μM), Influenza B HK (IC50=61 μM), and Avian myeloblastosis virus (IC50=5-8 μM), HSV-1, several strains (IC50=0.4-3.5 μM)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Foscarnet trisodium hexahydrate Related Antibodies
Molecular Weight

300.04

Formula

CH12Na3O11P
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(P(O[Na])(O[Na])=O)O[Na].[6H2O]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (166.64 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3329 mL 16.6644 mL 33.3289 mL
5 mM 0.6666 mL 3.3329 mL 6.6658 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.50%

COA (256 KB) CNMR (341 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.3329 mL 16.6644 mL 33.3289 mL 83.3222 mL
5 mM 0.6666 mL 3.3329 mL 6.6658 mL 16.6644 mL
10 mM 0.3333 mL 1.6664 mL 3.3329 mL 8.3322 mL
15 mM 0.2222 mL 1.1110 mL 2.2219 mL 5.5548 mL
20 mM 0.1666 mL 0.8332 mL 1.6664 mL 4.1661 mL
25 mM 0.1333 mL 0.6666 mL 1.3332 mL 3.3329 mL
30 mM 0.1111 mL 0.5555 mL 1.1110 mL 2.7774 mL
40 mM 0.0833 mL 0.4166 mL 0.8332 mL 2.0831 mL
50 mM 0.0667 mL 0.3333 mL 0.6666 mL 1.6664 mL
60 mM 0.0555 mL 0.2777 mL 0.5555 mL 1.3887 mL
80 mM 0.0417 mL 0.2083 mL 0.4166 mL 1.0415 mL
100 mM 0.0333 mL 0.1666 mL 0.3333 mL 0.8332 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Foscarnet trisodium hexahydrate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Foscarnet trisodium hexahydrate34156-56-4Trisodium phosphonoformate hexahydratePhosphonoformic acid trisodium salt hexahydrateDNA/RNA SynthesisInhibitorinhibitorinhibit

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