Foscarnet sodium (Synonyms: Trisodium phosphonoformate; Phosphonoformic acid trisodium salt)

Name: Foscarnet sodium
Brand: MedChemExpress
SKU: HY-B1318
Rating: 5.0 (3 reviews)

Cat. No.: HY-B1318 Pureza: 98.0%: Ficha de datos
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Foscarnet sodium (Trisodium phosphonoformate) is a viral DNA polymerase activity inhibitor, leading to reversible suppression of viral replication. Foscarnet sodium is an antiherpesvirus agent used in cytomegalovirus retinitis.

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Foscarnet sodium Estructura química

No. CAS : 63585-09-1

Tamaño	Stock	Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	En stock	Estimated Time of Arrival: December 31
Solid
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	En stock	Estimated Time of Arrival: December 31
200 mg	Obtener un presupuesto
500 mg	Obtener un presupuesto

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Revisión del cliente

Based on 3 publication(s) in Google Scholar

Other Forms of Foscarnet sodium:

Foscarnet trisodium hexahydrate In-stock
Foscarnet sodium (Standard) Obtener un presupuesto

3 Publications Citing Use of MCE Foscarnet sodium

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Ver todos los productos específicos de isoformas DNA/RNA Synthesis:

Ver todas las isoformas

RNASE L DNA Polymerases RNA Polymerases Helicases DNA Ligase

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Referencias
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Descripciòn

IC₅₀ & Target

DNA Polymerase

Cellular Effect

Cell Line	Type	Value	Description	References
HEL	IC₅₀	15.5 3 Compound: phosphonoformate	Inhibition of human CMV DNA synthesis in CMV-infected HEL cells. Inhibition of human CMV DNA synthesis in CMV-infected HEL cells.	[PMID: 7752205]
HFF	IC₅₀	>100 3 Compound: Foscarnet sodium	Compound was evaluated for the visual cytotoxicity scored on HFF cells at time of HCMV plaque enumeration Compound was evaluated for the visual cytotoxicity scored on HFF cells at time of HCMV plaque enumeration	[PMID: 7562945]
Vero	ED₅₀	230 3 Compound: Foscarnet sodium	Compound was tested for antiviral activity against Herpes simplex virus type 1 (HF) Compound was tested for antiviral activity against Herpes simplex virus type 1 (HF)	[PMID: 3016264]
Vero	ED₅₀	170 3 Compound: Foscarnet sodium	Compound was tested for antiviral activity against Herpes simplex virus type 1(KOS) Compound was tested for antiviral activity against Herpes simplex virus type 1(KOS)	[PMID: 3016264]
HEL	IC₅₀	15.5 3 Compound: phosphonoformate	Inhibition of human CMV DNA synthesis in CMV-infected HEL cells. Inhibition of human CMV DNA synthesis in CMV-infected HEL cells.	[PMID: 7752205]
Vero	ED₅₀	89 3 Compound: Foscarnet sodium	Compound was tested for antiviral activity against Herpes simplex virus type 2 (MS) Compound was tested for antiviral activity against Herpes simplex virus type 2 (MS)	[PMID: 3016264]
Vero	ED₅₀	20 3 Compound: Foscarnet sodium	Compound was tested for antiviral activity against Herpes simplex virus type 2 of strain 333 Compound was tested for antiviral activity against Herpes simplex virus type 2 of strain 333	[PMID: 3016264]
HFF	IC₅₀	> 100 3 Compound: Foscarnet sodium	Compound was evaluated for the visual cytotoxicity scored on HFF cells at time of HCMV plaque enumeration Compound was evaluated for the visual cytotoxicity scored on HFF cells at time of HCMV plaque enumeration	[PMID: 7562945]
Vero	ED₅₀	>5 2 Compound: Foscarnet sodium	Compound was tested for antiviral activity against measles virus Compound was tested for antiviral activity against measles virus	[PMID: 3016264]
Vero	ED₅₀	170 3 Compound: Foscarnet sodium	Compound was tested for antiviral activity against Herpes simplex virus type 1(KOS) Compound was tested for antiviral activity against Herpes simplex virus type 1(KOS)	[PMID: 3016264]
Vero	ED₅₀	5 2 Compound: Foscarnet sodium	Compound was tested for antiviral activity against para 3 Compound was tested for antiviral activity against para 3	[PMID: 3016264]
Vero	ED₅₀	20 3 Compound: Foscarnet sodium	Compound was tested for antiviral activity against Herpes simplex virus type 2 of strain 333 Compound was tested for antiviral activity against Herpes simplex virus type 2 of strain 333	[PMID: 3016264]
Vero	ED₅₀	230 3 Compound: Foscarnet sodium	Compound was tested for antiviral activity against Herpes simplex virus type 1 (HF) Compound was tested for antiviral activity against Herpes simplex virus type 1 (HF)	[PMID: 3016264]
Vero	ED₅₀	5000 3 Compound: Foscarnet sodium	Compound was tested for antiviral activity against para 3 Compound was tested for antiviral activity against para 3	[PMID: 3016264]
Vero	ED₅₀	89 3 Compound: Foscarnet sodium	Compound was tested for antiviral activity against Herpes simplex virus type 2 (MS) Compound was tested for antiviral activity against Herpes simplex virus type 2 (MS)	[PMID: 3016264]
Vero	ED₅₀	> 5000 3 Compound: Foscarnet sodium	Compound was tested for antiviral activity against measles virus Compound was tested for antiviral activity against measles virus	[PMID: 3016264]
Vero	ED₅₀	> 5000 3 Compound: Foscarnet sodium	Compound was tested for antiviral activity against vaccinia Compound was tested for antiviral activity against vaccinia	[PMID: 3016264]

In Vitro

Foscarnet sodium (Trisodium phosphonoformate) inhibits Influenza A Victoria (IC₅₀=29 μM), Influenza B HK (IC₅₀=61 μM), and Avian myeloblastosis virus (IC₅₀=5-8 μM),HSV-1, several strains (IC₅₀=0.4-3.5 μM)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Peso molecular

191.95

Fòrmula

CNa₃O₅P

No. CAS

63585-09-1

Appearance

Solid

Color

White to off-white

SMILES

O=P(O[Na])(O[Na])C(O[Na])=O

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvente y solubilidad

In Vitro:

H₂O : 16.67 mg/mL (86.85 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.2097 mL	26.0485 mL	52.0969 mL
5 mM	1.0419 mL	5.2097 mL	10.4194 mL
10 mM	0.5210 mL	2.6048 mL	5.2097 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Pureza y Documentación

Purity: 98.0%

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Ficha de datos (277 KB) SDS (393 KB)

COA (253 KB) CNMR (255 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Manischewitz JF, et al. Synergistic effect of ganciclovir and foscarnet on cytomegalovirus replication in vitro.Antimicrob Agents Chemother. 1990 Feb;34(2):373-5. [Content Brief]

[2]. Oberg B, et al. Antiviral effects of phosphonoformate (PFA, foscarnet sodium).Pharmacol Ther. 1982;19(3):387-415. [Content Brief]

[3]. Hakki M, et al. Moving Past Ganciclovir and Foscarnet: Advances in CMV Therapy.Curr Hematol Malig Rep. 2020 Jan 24. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	5.2097 mL	26.0485 mL	52.0969 mL	130.2423 mL
	5 mM	1.0419 mL	5.2097 mL	10.4194 mL	26.0485 mL
	10 mM	0.5210 mL	2.6048 mL	5.2097 mL	13.0242 mL
	15 mM	0.3473 mL	1.7366 mL	3.4731 mL	8.6828 mL
	20 mM	0.2605 mL	1.3024 mL	2.6048 mL	6.5121 mL
	25 mM	0.2084 mL	1.0419 mL	2.0839 mL	5.2097 mL
	30 mM	0.1737 mL	0.8683 mL	1.7366 mL	4.3414 mL
	40 mM	0.1302 mL	0.6512 mL	1.3024 mL	3.2561 mL
	50 mM	0.1042 mL	0.5210 mL	1.0419 mL	2.6048 mL
	60 mM	0.0868 mL	0.4341 mL	0.8683 mL	2.1707 mL
	80 mM	0.0651 mL	0.3256 mL	0.6512 mL	1.6280 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Foscarnet sodium Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Foscarnet63585-09-1Trisodium phosphonoformate Phosphonoformic acid trisodiumDNA/RNA SynthesisviralDNApolymerasereversiblesuppressionreplicationantiherpesviruscytomegalovirusretinitisInhibitorinhibitorinhibit

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Foscarnet sodium (Synonyms: Trisodium phosphonoformate; Phosphonoformic acid trisodium salt)

Revisión del cliente

Other Forms of Foscarnet sodium:

Foscarnet sodium Related Antibodies

3 Publications Citing Use of MCE Foscarnet sodium

Recomendaciones destacadas

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Ver todos los productos específicos de isoformas DNA/RNA Synthesis:

Actividad biológica

Pureza y Documentación

Referencias

Revisión del cliente

Foscarnet sodium Related Antibodies

Calculadora de molaridad

Calculadora de dilución

Complete Stock Solution Preparation Table

Foscarnet sodium Related Classifications

Keywords:

Productos vistos recientemente:

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