2. Protein Tyrosine Kinase/RTK PI3K/Akt/mTOR
  3. VEGFR Tie Akt
  4. Gersizangitide

Gersizangitide (AXT107) is an anti-angiogenic peptide consisting of 20 amino acids, derived from collagen IV. Gersizangitide is an inhibitor of VEGF-A and VEGF-C and an activator of Tie2. Gersizangitide can block VEGF receptor signaling, inhibit vascular leakage, neovascularization and inflammation. Gersizangitide can be used in the research of diseases related to ocular neovascularization and angiogenesis.

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Kundenspezifische Peptidsynthese

Gersizangitide

Gersizangitide Chemische Struktur

CAS. Nr. : 2417491-82-6

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Gersizangitide Related Antibodies

Top Publications Citing Use of Products

Alle VEGFR Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen
VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

Alle Tie Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen
Tie1 Tie2

Alle Akt Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen
Akt Akt1 Akt2 Akt3

  • Biologische Aktivität

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Beschreibung

Gersizangitide (AXT107) is an anti-angiogenic peptide consisting of 20 amino acids, derived from collagen IV. Gersizangitide is an inhibitor of VEGF-A and VEGF-C and an activator of Tie2. Gersizangitide can block VEGF receptor signaling, inhibit vascular leakage, neovascularization and inflammation. Gersizangitide can be used in the research of diseases related to ocular neovascularization and angiogenesis[1][2].

IC50 & Target[1]

Tie2

 

VEGF-A

 

VEGF-C

 

In Vitro

Gersizangitide (0-100 μM; 105 min) can enhance the phosphorylation of Tie2 and Akt induced by Ang2 in microvascular endothelial cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Gersizangitide Related Antibodies

Western Blot Analysis[2]

Cell Line: Microvascular endothelial cells treated Ang2
Concentration: 0, 10, 32 and 100 μM
Incubation Time: Pretreated with 75 min, then co-incubation for 30 min
Result: Increased the phosphorylation levels of Tie2 and Akt in a dose-dependent manner.
In Vivo

Gersizangitide (1 μg; intravitreal injection; single dose) enhances the phosphorylation of Tie2 in the endothelial cells of retinal neovascularization in a mouse model of oxygen-induced ischemic retinopathy[2].
Gersizangitide (1 μg; intravitreal injection; single dose) inhibits vascular leakage and reduces the level of albumin in the vitreous humor in a mouse model of uveitis induced by LPS (HY-D1056)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Klinische Studie
Molekulargewicht

2355.69

Formel

C111H167N29O28
CAS. Nr.
Appearance

Solid

Color

White to off-white

Sequence Shortening

LRRFSTAPFAFIDINDVINF-NH2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Lösungsmittel & Löslichkeit
In Vitro: 

H2O : 33.33 mg/mL (14.15 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.4245 mL 2.1225 mL 4.2450 mL
5 mM 0.0849 mL 0.4245 mL 0.8490 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molaritätsrechner

  • Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Reinheit & Dokumentation
Verweise

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.4245 mL 2.1225 mL 4.2450 mL 10.6126 mL
5 mM 0.0849 mL 0.4245 mL 0.8490 mL 2.1225 mL
10 mM 0.0425 mL 0.2123 mL 0.4245 mL 1.0613 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Gersizangitide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gersizangitide2417491-82-6AXT-107AXT107AXT 107VEGFRTieAktVascular endothelial growth factor receptorAngiopoietin receptorPKBProtein kinase Bangiogenesismicrovascular endothelial cellsischemic retinopathy modeluveitis modelInhibitorinhibitorinhibit

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