2. Protein Tyrosine Kinase/RTK PI3K/Akt/mTOR
  3. VEGFR Tie Akt
  4. Gersizangitide

Gersizangitide (AXT107) is an anti-angiogenic peptide consisting of 20 amino acids, derived from collagen IV. Gersizangitide is an inhibitor of VEGF-A and VEGF-C and an activator of Tie2. Gersizangitide can block VEGF receptor signaling, inhibit vascular leakage, neovascularization and inflammation. Gersizangitide can be used in the research of diseases related to ocular neovascularization and angiogenesis.

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Custom Peptide Synthesis

Gersizangitide

Gersizangitide 화학구조

CAS No. : 2417491-82-6

사이즈 가격 재고 수량
5 mg 해외재고보유
10 mg 해외재고보유
50 mg   견적 받기  
100 mg   견적 받기  

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

Gersizangitide Related Antibodies

Top Publications Citing Use of Products

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VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

View All Tie Isoform Specific Products:

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Tie1 Tie2

View All Akt Isoform Specific Products:

View All Isoforms
Akt Akt1 Akt2 Akt3

  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

Gersizangitide (AXT107) is an anti-angiogenic peptide consisting of 20 amino acids, derived from collagen IV. Gersizangitide is an inhibitor of VEGF-A and VEGF-C and an activator of Tie2. Gersizangitide can block VEGF receptor signaling, inhibit vascular leakage, neovascularization and inflammation. Gersizangitide can be used in the research of diseases related to ocular neovascularization and angiogenesis[1][2].

IC50 & Target[1]

Tie2

 

VEGF-A

 

VEGF-C

 

In Vitro

Gersizangitide (0-100 μM; 105 min) can enhance the phosphorylation of Tie2 and Akt induced by Ang2 in microvascular endothelial cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Gersizangitide Related Antibodies

Western Blot Analysis[2]

Cell Line: Microvascular endothelial cells treated Ang2
Concentration: 0, 10, 32 and 100 μM
Incubation Time: Pretreated with 75 min, then co-incubation for 30 min
Result: Increased the phosphorylation levels of Tie2 and Akt in a dose-dependent manner.
In Vivo

Gersizangitide (1 μg; intravitreal injection; single dose) enhances the phosphorylation of Tie2 in the endothelial cells of retinal neovascularization in a mouse model of oxygen-induced ischemic retinopathy[2].
Gersizangitide (1 μg; intravitreal injection; single dose) inhibits vascular leakage and reduces the level of albumin in the vitreous humor in a mouse model of uveitis induced by LPS (HY-D1056)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
분자량

2355.69

화학식

C111H167N29O28
CAS No.
Appearance

Solid

Color

White to off-white

Sequence Shortening

LRRFSTAPFAFIDINDVINF-NH2
선적

Room temperature in continental US; may vary elsewhere.
보관

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

용액&용해도
In Vitro: 

H2O : 33.33 mg/mL (14.15 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.4245 mL 2.1225 mL 4.2450 mL
5 mM 0.0849 mL 0.4245 mL 0.8490 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
순도&문서
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.4245 mL 2.1225 mL 4.2450 mL 10.6126 mL
5 mM 0.0849 mL 0.4245 mL 0.8490 mL 2.1225 mL
10 mM 0.0425 mL 0.2123 mL 0.4245 mL 1.0613 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Gersizangitide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gersizangitide2417491-82-6AXT-107AXT107AXT 107VEGFRTieAktVascular endothelial growth factor receptorAngiopoietin receptorPKBProtein kinase Bangiogenesismicrovascular endothelial cellsischemic retinopathy modeluveitis modelInhibitorinhibitorinhibit

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상품명:
Gersizangitide
Cat. No.:
HY-P3369
수량:
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