2. Others Metabolic Enzyme/Protease Membrane Transporter/Ion Channel Anti-infection
  3. Sodium Channel Environmental Pollutants Bacterial Carbonic Anhydrase
  4. Halazone

Halazone is an atypical antimicrobial sulfonamide derivative and a carbonic anhydrase II inhibitor with a Kd value of 1.45 μM. Halazone protects sodium channels from inactivation. Halazone is widely used for disinfection of drinking water.

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Halazone

Halazone Estructura química

No. CAS : 80-13-7

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Halazone Related Antibodies

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Descripciòn

Halazone is an atypical antimicrobial sulfonamide derivative and a carbonic anhydrase II inhibitor with a Kd value of 1.45 μM. Halazone protects sodium channels from inactivation. Halazone is widely used for disinfection of drinking water[1][2].

IC50 & Target

CA Ⅱ

 

In Vitro

Halazone is chemically closely related to Chloramine-T, the nitrogen atom is linked with two instead of one chlorine atom and, certainly more important here, a methyl group is replaced by a carboxyl group. The effect of Halazone on the sodium current is studied in voltage-clamped single nerve fibers of the frog. The oxidant Halazone drastically inhibits inactivation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Halazone Related Antibodies
Peso molecular

270.09

Fòrmula

C7H5Cl2NO4S
No. CAS
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)C1=CC=C(S(=O)(N(Cl)Cl)=O)C=C1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

4°C, sealed storage, away from moisture

*The compound is unstable in solutions, freshly prepared is recommended.

Solvente y solubilidad
In Vitro: 

DMSO : 100 mg/mL (370.25 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7025 mL 18.5123 mL 37.0247 mL
5 mM 0.7405 mL 3.7025 mL 7.4049 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Pureza y Documentación
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.7025 mL 18.5123 mL 37.0247 mL 92.5617 mL
5 mM 0.7405 mL 3.7025 mL 7.4049 mL 18.5123 mL
10 mM 0.3702 mL 1.8512 mL 3.7025 mL 9.2562 mL
15 mM 0.2468 mL 1.2342 mL 2.4683 mL 6.1708 mL
20 mM 0.1851 mL 0.9256 mL 1.8512 mL 4.6281 mL
25 mM 0.1481 mL 0.7405 mL 1.4810 mL 3.7025 mL
30 mM 0.1234 mL 0.6171 mL 1.2342 mL 3.0854 mL
40 mM 0.0926 mL 0.4628 mL 0.9256 mL 2.3140 mL
50 mM 0.0740 mL 0.3702 mL 0.7405 mL 1.8512 mL
60 mM 0.0617 mL 0.3085 mL 0.6171 mL 1.5427 mL
80 mM 0.0463 mL 0.2314 mL 0.4628 mL 1.1570 mL
100 mM 0.0370 mL 0.1851 mL 0.3702 mL 0.9256 mL
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Halazone Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Halazone80-13-7Sodium ChannelEnvironmental PollutantsBacterialCarbonic AnhydraseNa channelsNa+ channelsEnvironmental ContaminantsCarbonate dehydrataseOxidizingbiocidedisinfectiondrinkingwaterantimicrobialsulfonamidecarbonicanhydraseInhibitorinhibitorinhibit

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Nombre del producto:
Halazone
Cat. No.:
HY-B1386
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