2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC
  4. HDAC-IN-38

HDAC-IN-38 (compound 13) is a potent HDAC inhibitor. HDAC-IN-38 shows similar micro-molar inhibitory activity toward HDAC1, 2, 3, 5, 6, and 8. HDAC-IN-38 increases cerebral blood flow (CBF), attenuates cognitive impairment, and improves hippocampal atrophy. HDAC-IN-38 also increases the level of histone acetylation (H3K14 or H4K5).

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HDAC-IN-38

HDAC-IN-38 화학구조

CAS No. : 2408123-36-2

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HDAC-IN-38 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE HDAC-IN-38

View All HDAC Isoform Specific Products:

View All Isoforms
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

HDAC-IN-38 (compound 13) is a potent HDAC inhibitor. HDAC-IN-38 shows similar micro-molar inhibitory activity toward HDAC1, 2, 3, 5, 6, and 8. HDAC-IN-38 increases cerebral blood flow (CBF), attenuates cognitive impairment, and improves hippocampal atrophy. HDAC-IN-38 also increases the level of histone acetylation (H3K14 or H4K5)[1].

IC50 & Target

HDAC8

0.533 μM (IC50)

HDAC6

1.27 μM (IC50)

HDAC3

2.86 μM (IC50)

HDAC1

3.82 μM (IC50)

HDAC5

6.27 μM (IC50)

HDAC2

6.62 μM (IC50)

Cellular Effect
Cell Line Type Value Description References
Sf21 IC50
3.82 μM
Compound: 13
Inhibition of recombinant full length human C-terminal FLAG/His-tagged HDAC1 (1 to 482 residues) expressed in baculovirus infected Sf21 cells using RHK-K(Ac)-AMC as substrate measured after 60 mins by fluorimetric assay
Inhibition of recombinant full length human C-terminal FLAG/His-tagged HDAC1 (1 to 482 residues) expressed in baculovirus infected Sf21 cells using RHK-K(Ac)-AMC as substrate measured after 60 mins by fluorimetric assay
[PMID: 31838329]
Sf21 IC50
3.82 × 10-6M
Compound: 13
Inhibition of recombinant full length human C-terminal FLAG/His-tagged HDAC1 (1 to 482 residues) expressed in baculovirus infected Sf21 cells using RHK-K(Ac)-AMC as substrate measured after 60 mins by fluorimetric assay
Inhibition of recombinant full length human C-terminal FLAG/His-tagged HDAC1 (1 to 482 residues) expressed in baculovirus infected Sf21 cells using RHK-K(Ac)-AMC as substrate measured after 60 mins by fluorimetric assay
[PMID: 31838329]
Sf21 IC50
3.82 x 10-6M
Compound: 13
Inhibition of recombinant full length human C-terminal FLAG/His-tagged HDAC1 (1 to 482 residues) expressed in baculovirus infected Sf21 cells using RHK-K(Ac)-AMC as substrate measured after 60 mins by fluorimetric assay
Inhibition of recombinant full length human C-terminal FLAG/His-tagged HDAC1 (1 to 482 residues) expressed in baculovirus infected Sf21 cells using RHK-K(Ac)-AMC as substrate measured after 60 mins by fluorimetric assay
[PMID: 31838329]
Sf21 IC50
6.62 μM
Compound: 13
Inhibition of recombinant human C-terminal GST-tagged HDAC2 (1 to 488 residues) expressed in baculovirus infected sf21 cells using RHK-K(Ac)-AMC as substrate after 60 mins by fluorimetry assay
Inhibition of recombinant human C-terminal GST-tagged HDAC2 (1 to 488 residues) expressed in baculovirus infected sf21 cells using RHK-K(Ac)-AMC as substrate after 60 mins by fluorimetry assay
[PMID: 31838329]
Sf21 IC50
6.62 × 10-6M
Compound: 13
Inhibition of recombinant human C-terminal GST-tagged HDAC2 (1 to 488 residues) expressed in baculovirus infected sf21 cells using RHK-K(Ac)-AMC as substrate after 60 mins by fluorimetry assay
Inhibition of recombinant human C-terminal GST-tagged HDAC2 (1 to 488 residues) expressed in baculovirus infected sf21 cells using RHK-K(Ac)-AMC as substrate after 60 mins by fluorimetry assay
[PMID: 31838329]
Sf21 IC50
6.62 x 10-6M
Compound: 13
Inhibition of recombinant human C-terminal GST-tagged HDAC2 (1 to 488 residues) expressed in baculovirus infected sf21 cells using RHK-K(Ac)-AMC as substrate after 60 mins by fluorimetry assay
Inhibition of recombinant human C-terminal GST-tagged HDAC2 (1 to 488 residues) expressed in baculovirus infected sf21 cells using RHK-K(Ac)-AMC as substrate after 60 mins by fluorimetry assay
[PMID: 31838329]
분자량

461.98

화학식

C27H28ClN3O2
CAS No.
SMILES

O=C(NO)/C=C/C1=CC=C(C=C1)CNCCCN2C3=C(CCC4=C2C=C(C=C4)Cl)C=CC=C3
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
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HDAC-IN-38 Related Classifications

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  • 농도 희석 계산기

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC-IN-382408123-36-2HDACHistone deacetylasesSH-SY5Y cellsVascular cognitive impairmentNeurodegenerative diseaseHistone deacetylase inhibitorshippocampal atrophyInhibitorinhibitorinhibit

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상품명:
HDAC-IN-38
Cat. No.:
HY-146351
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