2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. ISM5939

ISM5939 is an orally active and selective ENPP1 inhibitor with an IC50 of 0.63 nM for 2,3-cGAMP degradation and 9.28 nM for ATP hydrolysis. ISM5939 has antitumor activity.

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ISM5939

ISM5939 Chemical Structure

CAS No. : 2965301-60-2

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
5 mg In-stock
10 mg In-stock
25 mg In-stock
50 mg In-stock
100 mg In-stock
200 mg   Get quote  
500 mg   Get quote  

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ISM5939 Related Antibodies

Top Publications Citing Use of Products

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PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

  • Biological Activity

  • Purity & Documentation

  • References

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Description

ISM5939 is an orally active and selective ENPP1 inhibitor with an IC50 of 0.63 nM for 2,3-cGAMP degradation and 9.28 nM for ATP hydrolysis. ISM5939 has antitumor activity[1].

Parmacokinetics
Species Dose Route Bioavailability Clearance (CL) Vss
Mice[1] 1 mg/kg i.v. 32 % 14 mL/min/kg 0.53 L/kg
Mice[1] 5 mg/kg p.o. 32 % 14 mL/min/kg 0.53 L/kg
Mice[1] 1 mg/kg i.v. 49 % 14 mL/min/kg 1.1 L/kg
Mice[1] 5 mg/kg p.o. 49 % 14 mL/min/kg 1.1 L/kg
Mice[1] 0.5 mg/kg i.v. 45 % 2.0 mL/min/kg 0.63 L/kg
Mice[1] 1 mg/kg p.o. 45 % 2.0 mL/min/kg 0.63 L/kg
Clinical Trial
Molecular Weight

427.45

Formula

C20H18FN5O3S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

COC1=C(C2=CC=CC=C2)C3=C(C=N1)N=C(C)N3CC4=C(F)C=C(S(N)(=O)=O)C=N4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (467.89 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3395 mL 11.6973 mL 23.3945 mL
5 mM 0.4679 mL 2.3395 mL 4.6789 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3395 mL 11.6973 mL 23.3945 mL 58.4864 mL
5 mM 0.4679 mL 2.3395 mL 4.6789 mL 11.6973 mL
10 mM 0.2339 mL 1.1697 mL 2.3395 mL 5.8486 mL
15 mM 0.1560 mL 0.7798 mL 1.5596 mL 3.8991 mL
20 mM 0.1170 mL 0.5849 mL 1.1697 mL 2.9243 mL
25 mM 0.0936 mL 0.4679 mL 0.9358 mL 2.3395 mL
30 mM 0.0780 mL 0.3899 mL 0.7798 mL 1.9495 mL
40 mM 0.0585 mL 0.2924 mL 0.5849 mL 1.4622 mL
50 mM 0.0468 mL 0.2339 mL 0.4679 mL 1.1697 mL
60 mM 0.0390 mL 0.1950 mL 0.3899 mL 0.9748 mL
80 mM 0.0292 mL 0.1462 mL 0.2924 mL 0.7311 mL
100 mM 0.0234 mL 0.1170 mL 0.2339 mL 0.5849 mL
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ISM5939 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ISM59392965301-60-2ISM 5939ISM-5939Phosphodiesterase (PDE)ENPP1InhibitorAntitumorinhibitorinhibit

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