L-Homocysteine-d₄

Cat. No.: HY-W653733: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

L-Homocysteine-d₄ is deuterium labeled L-Homocysteine (HY-W010347). L-Homocysteine, an amino acid, is a homocysteine that has L configuration. Homocysteine is an essential intermediate in normal mammalian metabolism of methionine. L-Homocysteine induces upregulation of Cathepsin V that mediates vascular endothelial inflammation in hyperhomocysteinaemia

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L-Homocysteine-d₄ 화학구조

CAS No. : 331665-12-4

사이즈	가격	재고
500 μg		Ask For Quote & Lead Time
1 mg		Ask For Quote & Lead Time

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

Other Forms of L-Homocysteine-d₄:

L-Homocysteine In-stock

1 Publications Citing Use of MCE L-Homocysteine-d₄

•J Pharm Biomed Anal. 2025 Oct 3:268:117178. [Abstract]

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•Related Small Molecules:

•Related Proteins:

View All Endogenous Metabolite Isoform Specific Products:

View All Isoforms

Human Endogenous Metabolite Microbial Metabolite

View All Cathepsin Isoform Specific Products:

View All Isoforms

Cathepsin B Cathepsin C Cathepsin D Cathepsin E Cathepsin K Cathepsin L Cathepsin S

Biological Activity
순도&문서
References
고객리뷰

제품 설명

L-Homocysteine-d₄ is deuterium labeled L-Homocysteine (HY-W010347)^[1]. L-Homocysteine, an amino acid, is a homocysteine that has L configuration. Homocysteine is an essential intermediate in normal mammalian metabolism of methionine. L-Homocysteine induces upregulation of Cathepsin V that mediates vascular endothelial inflammation in hyperhomocysteinaemia

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

139.21

화학식

C₄H₅D₄NO₂S

CAS No.

331665-12-4

Unlabeled CAS

6027-13-0

Appearance

Solid

Color

White to off-white

SMILES

SC([2H])([2H])C([2H])([2H])[C@H](N)C(O)=O

선적

Room temperature in continental US; may vary elsewhere.

보관

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

용액&용해도

In Vitro:

H2O : 25 mg/mL (179.58 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	7.1834 mL	35.9170 mL	71.8339 mL
5 mM	1.4367 mL	7.1834 mL	14.3668 mL
10 mM	0.7183 mL	3.5917 mL	7.1834 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

순도&문서

Purity: 94.89%

Select Batch:

Data Sheet (274 KB) SDS (394 KB)

COA (250 KB) Elemental Analysis Report (109 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H2O	1 mM	7.1834 mL	35.9170 mL	71.8339 mL	179.5848 mL
	5 mM	1.4367 mL	7.1834 mL	14.3668 mL	35.9170 mL
	10 mM	0.7183 mL	3.5917 mL	7.1834 mL	17.9585 mL
	15 mM	0.4789 mL	2.3945 mL	4.7889 mL	11.9723 mL
	20 mM	0.3592 mL	1.7958 mL	3.5917 mL	8.9792 mL
	25 mM	0.2873 mL	1.4367 mL	2.8734 mL	7.1834 mL
	30 mM	0.2394 mL	1.1972 mL	2.3945 mL	5.9862 mL
	40 mM	0.1796 mL	0.8979 mL	1.7958 mL	4.4896 mL
	50 mM	0.1437 mL	0.7183 mL	1.4367 mL	3.5917 mL
	60 mM	0.1197 mL	0.5986 mL	1.1972 mL	2.9931 mL
	80 mM	0.0898 mL	0.4490 mL	0.8979 mL	2.2448 mL
	100 mM	0.0718 mL	0.3592 mL	0.7183 mL	1.7958 mL