2. MAPK/ERK Pathway
  3. MEK
  4. MEK4 inhibitor-1

MEK4 inhibitor-1 is a novel MEK4 inhibitor against pancreatic adenocarcinoma with an IC50 value of 61 nM.

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MEK4 inhibitor-1

MEK4 inhibitor-1 Chemische Struktur

CAS. Nr. : 2570386-36-4

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MEK4 inhibitor-1 Related Antibodies

Top Publications Citing Use of Products

Alle MEK Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen
MEK1 MEK2 MEK5 MEK MAP2K4/MEK4 MAP2K7/MEK7

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Beschreibung

MEK4 inhibitor-1 is a novel MEK4 inhibitor against pancreatic adenocarcinoma with an IC50 value of 61 nM.

Molekulargewicht

291.30

Formel

C13H10FN3O2S
CAS. Nr.
Appearance

Solid

Color

White to off-white

SMILES

FC1=CC=C(C(C2=CC=C(S(=O)(N)=O)C=C2)=NN3)C3=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Lösungsmittel & Löslichkeit
In Vitro: 

DMSO : 125 mg/mL (429.11 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4329 mL 17.1644 mL 34.3289 mL
5 mM 0.6866 mL 3.4329 mL 6.8658 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molaritätsrechner

  • Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Reinheit & Dokumentation
Verweise

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4329 mL 17.1644 mL 34.3289 mL 85.8222 mL
5 mM 0.6866 mL 3.4329 mL 6.8658 mL 17.1644 mL
10 mM 0.3433 mL 1.7164 mL 3.4329 mL 8.5822 mL
15 mM 0.2289 mL 1.1443 mL 2.2886 mL 5.7215 mL
20 mM 0.1716 mL 0.8582 mL 1.7164 mL 4.2911 mL
25 mM 0.1373 mL 0.6866 mL 1.3732 mL 3.4329 mL
30 mM 0.1144 mL 0.5721 mL 1.1443 mL 2.8607 mL
40 mM 0.0858 mL 0.4291 mL 0.8582 mL 2.1456 mL
50 mM 0.0687 mL 0.3433 mL 0.6866 mL 1.7164 mL
60 mM 0.0572 mL 0.2861 mL 0.5721 mL 1.4304 mL
80 mM 0.0429 mL 0.2146 mL 0.4291 mL 1.0728 mL
100 mM 0.0343 mL 0.1716 mL 0.3433 mL 0.8582 mL
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MEK4 inhibitor-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MEK4 inhibitor-12570386-36-4MEKMitogen-activated protein kinase kinaseMAPKKMAP2KInhibitorinhibitorinhibit

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