2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis Topoisomerase
  4. MGB4

MGB4 is a DNA minor groove binder. MGB4 binds to ARE-containing DNA and inhibition of topoisomerase I activity. MGB4 can impacts key cellular pathways, including inhibition oftranslation and alterations in sphingolipid and amino acid metabolism. MGB4 also reduces spermine and spermidine metabolism companied with Doxorubicin (HY-15142A). MGB4 can be used for the research of cancer, such as Prostate cancer.

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MGB4

MGB4 Estructura química

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MGB4 Related Antibodies

Top Publications Citing Use of Products

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RNASE L DNA Polymerases RNA Polymerases Helicases DNA Ligase

Ver todos los productos específicos de isoformas Topoisomerase:

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Topoisomerase Topo I Topo II DNA gyrase

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Descripciòn

MGB4 is a DNA minor groove binder. MGB4 binds to ARE-containing DNA and inhibition of topoisomerase I activity. MGB4 can impacts key cellular pathways, including inhibition oftranslation and alterations in sphingolipid and amino acid metabolism. MGB4 also reduces spermine and spermidine metabolism companied with Doxorubicin (HY-15142A). MGB4 can be used for the research of cancer, such as Prostate cancer[1].

IC50 & Target[1]

Topoisomerase I

 

Peso molecular

739.79

Fòrmula

C30H36F3N9O6S2
SMILES

O=C(C1=C(C(C)C)SC(NC(C2=CC(NC(C3=CC(NC(C4=CSC=N4)=O)=CN3C)=O)=CN2C)=O)=N1)NCCCN(C)C.FC(F)(C(O)=O)F
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
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MGB4 Related Classifications

  • Calculadora de molaridad

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MGB4MGB 4MGB-4DNA/RNA SynthesisTopoisomeraseDNAAREtopoisomerase Ioftranslationalterationssphingolipidamino acidsperminespermidineDoxorubicinCancerProstate cancerInhibitorinhibitorinhibit

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Nombre del producto:
MGB4
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HY-178174
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