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  4. Monactin

Monactin is a mactrotetralide antibiotic and a non-selective ionophore for monovalent cations, including potassium, sodium, and lithium. Monactin is isolated from Streptomyces and has antiproliferative activity.

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Monactin

Monactin 화학구조

CAS No. : 7182-54-9

사이즈 가격 재고 수량
1 mg 견적 받기 3 - 4 Weeks 4 - 5 weeks 5 - 6 weeks 2 - 3 weeks
5 mg 견적 받기

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Monactin Related Antibodies

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제품 설명

Monactin is a mactrotetralide antibiotic and a non-selective ionophore for monovalent cations, including potassium, sodium, and lithium. Monactin is isolated from Streptomyces and has antiproliferative activity[1][2][3].

In Vitro

Monactin displays strong antiproliferative activity against A2780 ovarian cancer cells (IC50 0.13 μM), A2058 melanoma cells (0.02 μM), and H522-T1 non small-cell cancer lung cells (0.01 μM)[3].
Monactin inhibits TCF/β-catenin transcriptional activity[4].
At a concentration of 10 μM, nigericin and monactin inhibited growth of Streptococcus faecalis, and the inhibition was reversed by addition of excess K(+)[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Monactin Related Antibodies
In Vivo

Monactin is potent uncoupler of oxidative phosphorylation and inducer of ATP hydrolysis in rat liver mitochondria[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
분자량

750.96

화학식

C41H66O12
CAS No.
SMILES

CC[C@@H](OC([C@@H]([C@H]1O[C@@](C[C@@H](OC([C@H]([C@@](CC2)([H])O[C@@]2([H])C3)C)=O)C)([H])CC1)C)=O)C[C@]4([H])O[C@@]([C@@H](C(O[C@H](C[C@@]5([H])O[C@H]([C@H](C(O[C@@H]3C)=O)C)CC5)C)=O)C)([H])CC4
Structure Classification
Initial Source

Streptomyces griseus
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
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Monactin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Monactin7182-54-9Oxidative PhosphorylationBacterialAntibiotictranscriptionalmactrotetralideionophorecationsantiproliferativeInhibitorinhibitorinhibit

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상품명:
Monactin
Cat. No.:
HY-111525
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