N-(3-Aminopropyl)cyclohexylamine

Cat. No.: HY-W015514 Pureza: 98.80%: Ficha de datos
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N-(3-Aminopropyl)cyclohexylamine, a cyclohexylamine derivative, acts as a selective and competitive inhibitor of spermine synthase. N-(3-Aminopropyl)cyclohexylamine can be used for the research of neurological diseases.

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N-(3-Aminopropyl)cyclohexylamine Estructura química

No. CAS : 3312-60-5

Tamaño	Stock	Cantidad
Liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	En stock	Estimated Time of Arrival: December 31
Liquid
100 mg	En stock	Estimated Time of Arrival: December 31
200 mg	Obtener un presupuesto
500 mg	Obtener un presupuesto

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Descripciòn

In Vitro

N-(3-Aminopropyl)cyclohexylamine (100 µM, 3 days) reduces the intracellular spermine content, increases the spermidine content, and decreases glucose-induced insulin secretion in cell Beta-TC6^[3].
N-(3-Aminopropyl)cyclohexylamine (100 µM, 5-8 days) promotes lipid accumulation and GPDH activity in preadipocytes, and inhibits lipid accumulation in mature adipocytes^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

N-(3-Aminopropyl)cyclohexylamine (25 mg/kg, ip, once daily for 2 days) exhibits anti-epileptic effect in WAG/Rij rat model^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	WAG/Rij rat model^[2]
Dosage:	25 mg/kg
Administration:	ip, once daily for 2 days
Result:	Increased spike-wave discharge activity without affecting its duration.

Peso molecular

156.27

Fòrmula

C₉H₂₀N₂

No. CAS

3312-60-5

Appearance

Liquid (Density: 0.917 g/cm³)

Color

Colorless to light yellow

SMILES

NCCCNC1CCCCC1

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvente y solubilidad

In Vitro:

DMSO : 100 mg/mL (639.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 100 mg/mL (639.92 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.3992 mL	31.9959 mL	63.9918 mL
5 mM	1.2798 mL	6.3992 mL	12.7984 mL
10 mM	0.6399 mL	3.1996 mL	6.3992 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (639.92 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Pureza y Documentación

Purity: 99.00%

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Ficha de datos (270 KB) SDS (476 KB)

COA (242 KB) HNMR (125 KB) GC (264 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. P J Chu, et al.Antagonistic effect of N-(3-Aminopropyl)cyclohexylamine on neurotrophic action of spermine in primary cultured rat hippocampal and cerebellar neurons. Jpn J Pharmacol. 1995 Dec;69(4):311-5. [Content Brief]

[2]. Kovács Z, et al., Critical Role of Astrocytic Polyamine and GABA Metabolism in Epileptogenesis. Front Cell Neurosci. 2022 Jan 6;15:787319. [Content Brief]

[3]. Ohtani M, et al., Spermidine regulates insulin synthesis and cytoplasmic Ca(2+) in mouse beta-TC6 insulinoma cells. Cell Struct Funct. 2009;34(2):105-13. [Content Brief]

[4]. Ishii I, et al., Polyamine metabolism is involved in adipogenesis of 3T3-L1 cells. Amino Acids. 2012 Feb;42(2-3):619-26. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	6.3992 mL	31.9959 mL	63.9918 mL	159.9795 mL
	5 mM	1.2798 mL	6.3992 mL	12.7984 mL	31.9959 mL
	10 mM	0.6399 mL	3.1996 mL	6.3992 mL	15.9980 mL
	15 mM	0.4266 mL	2.1331 mL	4.2661 mL	10.6653 mL
	20 mM	0.3200 mL	1.5998 mL	3.1996 mL	7.9990 mL
	25 mM	0.2560 mL	1.2798 mL	2.5597 mL	6.3992 mL
	30 mM	0.2133 mL	1.0665 mL	2.1331 mL	5.3327 mL
	40 mM	0.1600 mL	0.7999 mL	1.5998 mL	3.9995 mL
	50 mM	0.1280 mL	0.6399 mL	1.2798 mL	3.1996 mL
	60 mM	0.1067 mL	0.5333 mL	1.0665 mL	2.6663 mL
	80 mM	0.0800 mL	0.3999 mL	0.7999 mL	1.9997 mL
	100 mM	0.0640 mL	0.3200 mL	0.6399 mL	1.5998 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.