2. Metabolic Enzyme/Protease
  3. Cathepsin
  4. N-CBZ-Phe-Arg-AMC

N-CBZ-Phe-Arg-AMC (Z-FR-AMC) is a cathepsin substrate used in assessment activity of lysosomal cathepsin enzymes.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Synthèse de peptides personnalisée

N-CBZ-Phe-Arg-AMC

N-CBZ-Phe-Arg-AMC Chemical Structure

CAS No. : 65147-22-0

Size Prix Stock Quantité
5 mg En stock
10 mg En stock
50 mg   Obtenir un devis  
100 mg   Obtenir un devis  

* Veuillez sélectionner la quantité avant d'ajouter des articles.

This product is a controlled substance and not for sale in your territory.

Avis client

Based on 1 Customer Validation

Other Forms of N-CBZ-Phe-Arg-AMC:

N-CBZ-Phe-Arg-AMC Related Antibodies

Top Publications Citing Use of Products

Voir tous les produits spécifiques à Isoform Cathepsin:

Voir toutes les isoformes
Cathepsin B Cathepsin C Cathepsin D Cathepsin E Cathepsin K Cathepsin L Cathepsin S

  • Activité biologique

  • Pureté et documentation

  • Références

  • Avis client

Description

N-CBZ-Phe-Arg-AMC (Z-FR-AMC) is a cathepsin substrate used in assessment activity of lysosomal cathepsin enzymes[1][2].

In Vitro

N-CBZ-Phe-Arg-AMC (5 μM; 10-20 min) serves as a fluorescent substrate for trypsin, papain, and cathepsin B, enabling detection of apparent protease activity inhibition by myoglobin and hemin via reduced fluorescence signal[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

N-CBZ-Phe-Arg-AMC Related Antibodies
Masse moléculaire

612.68

Formule

C33H36N6O6
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

CBZ-Phe-Arg-AMC
Sequence Shortening

CBZ-FR-AMC
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvant et solubilité
In Vitro: 

DMSO : 100 mg/mL (163.22 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6322 mL 8.1609 mL 16.3217 mL
5 mM 0.3264 mL 1.6322 mL 3.2643 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculateur de molarité

  • Calculateur de dilution

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureté et documentation

Purity: 99.88%

SDS (396 KB)

COA (251 KB) LCMS (269 KB)

Instruction de manipulation (2659 KB)
Références

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6322 mL 8.1609 mL 16.3217 mL 40.8043 mL
5 mM 0.3264 mL 1.6322 mL 3.2643 mL 8.1609 mL
10 mM 0.1632 mL 0.8161 mL 1.6322 mL 4.0804 mL
15 mM 0.1088 mL 0.5441 mL 1.0881 mL 2.7203 mL
20 mM 0.0816 mL 0.4080 mL 0.8161 mL 2.0402 mL
25 mM 0.0653 mL 0.3264 mL 0.6529 mL 1.6322 mL
30 mM 0.0544 mL 0.2720 mL 0.5441 mL 1.3601 mL
40 mM 0.0408 mL 0.2040 mL 0.4080 mL 1.0201 mL
50 mM 0.0326 mL 0.1632 mL 0.3264 mL 0.8161 mL
60 mM 0.0272 mL 0.1360 mL 0.2720 mL 0.6801 mL
80 mM 0.0204 mL 0.1020 mL 0.2040 mL 0.5101 mL
100 mM 0.0163 mL 0.0816 mL 0.1632 mL 0.4080 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

N-CBZ-Phe-Arg-AMC Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-CBZ-Phe-Arg-AMC65147-22-0Z-FR-AMCCathepsinserine proteaseskallikreinplasminprimary porcine trabecular meshwork cellstrypsincathepsin Bprimary open-angle glaucomaheminmyoglobinpapainInhibitorinhibitorinhibit

Vos produits récemment consultés:

Demande en ligne

Your information is safe with us. * Required Fields.

Nom du produit

  

Requested Quantity *

Nom du demandeur *

 

Civilité

Adresse e-mail *

 

Numéro de téléphone *

Department

 

Nom de l'organisation *

City

État

Country or Region *

      

Remarques

Bulk Inquiry

Inquiry Information

Nom du produit:
N-CBZ-Phe-Arg-AMC
Cat. No.:
HY-P1759
Quantité:
MCE Japan Authorized Agent:

Avis client

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Nom du produit

  

Lot #

Nom du demandeur *

 

Adresse e-mail *

Numéro de téléphone

 

Department *

Nom de l'organisation *

 

Country or Region *

Remarques

SAFETY DATA SHEET (SDS)

English - EN (396 KB) Français - FR (396 KB) Deutsch - DE (396 KB) Norwegian - NO (396 KB) Español - ES (396 KB) Swedish - SV (396 KB) Italian - IT (396 KB) Korean - KR (396 KB) Portuguese - PT (396 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.