Nicotinic acid riboside

Name: Nicotinic acid riboside
Brand: MedChemExpress
SKU: HY-W104368
Rating: 4.5 (0 reviews)

製品番号: HY-W104368 純度: 99.90%: Data Sheet SDS COA 取扱説明書
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Nicotinic acid riboside is a NAD⁺ precursor in human cells. Nicotinic acid riboside is an authentic intermediate of human NAD⁺ metabolism.

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Nicotinic acid riboside 構造式

CAS 番号 : 17720-18-2

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	USD 198	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	USD 198	在庫あり	Estimated Time of Arrival: December 31
Solid
5 mg	$180	在庫あり	Estimated Time of Arrival: December 31
10 mg	$280	在庫あり	Estimated Time of Arrival: December 31
25 mg	$504	在庫あり	Estimated Time of Arrival: December 31
50 mg	$750	在庫あり	Estimated Time of Arrival: December 31
100 mg	$1200	在庫あり	Estimated Time of Arrival: December 31
200 mg		お問い合わせ
500 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 0 publication(s) in Google Scholar

Other Forms of Nicotinic acid riboside:

Nicotinic acid riboside-d₄ お問い合わせ
Nicotinic acid riboside (Standard) お問い合わせ

Endogenous Metabolite アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

Human Endogenous Metabolite Microbial Metabolite

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

Nicotinic acid riboside is a NAD⁺ precursor in human cells. Nicotinic acid riboside is an authentic intermediate of human NAD⁺ metabolism^[1]^[2].

体外実験

Nicotinic acid riboside (HepG2 cells; 0.01 nM~0.1 mM) helps FK866-treated cells to maintain viability at low micromolar concentrations^[1].
. Nicotinic acid riboside formation and release are caused by overexpression of FLAG-tagged CN-II and CN-III in HEK293 and HepG2 cells. CN-II and CN-III generate Nicotinic acid riboside in vitro by dephosphorylation of nicotinic acid mononucleotide (NAMN)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

255.23

分子式

C₁₁H₁₃NO₆

CAS 番号

17720-18-2

Appearance

Solid

Color

Off-white to light yellow

SMILES

[O-]C(C1=C[N+]([C@@H]2O[C@@H]([C@H]([C@H]2O)O)CO)=CC=C1)=O

Structure Classification

Initial Source

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

H₂O : 62.5 mg/mL (244.88 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.9180 mL	19.5902 mL	39.1803 mL
5 mM	0.7836 mL	3.9180 mL	7.8361 mL
10 mM	0.3918 mL	1.9590 mL	3.9180 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

体内:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (391.80 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

純度とドキュメンテーション

純度: 99.90%

Select Batch:

データシート (273 KB) SDS (393 KB)

COA (249 KB) HNMR (264 KB) RP-HPLC (204 KB) LCMS (102 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Sasaki Y, et al. Nicotinic acid mononucleotide is an allosteric SARM1 inhibitor promoting axonal protection. Exp Neurol. 2021;345:113842. [Content Brief]

[2]. Bogan KL, et al. Identification of Isn1 and Sdt1 as glucose- and vitamin-regulated nicotinamide mononucleotide and nicotinic acid mononucleotide [corrected] 5'-nucleotidases responsible for production of nicotinamide riboside and nicotinic acid riboside [published correction appears in J Biol Chem. 2010 Jan 29;285(5):3524]. J Biol Chem. 2009;284(50):34861-34869. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	3.9180 mL	19.5902 mL	39.1803 mL	97.9509 mL
	5 mM	0.7836 mL	3.9180 mL	7.8361 mL	19.5902 mL
	10 mM	0.3918 mL	1.9590 mL	3.9180 mL	9.7951 mL
	15 mM	0.2612 mL	1.3060 mL	2.6120 mL	6.5301 mL
	20 mM	0.1959 mL	0.9795 mL	1.9590 mL	4.8975 mL
	25 mM	0.1567 mL	0.7836 mL	1.5672 mL	3.9180 mL
	30 mM	0.1306 mL	0.6530 mL	1.3060 mL	3.2650 mL
	40 mM	0.0980 mL	0.4898 mL	0.9795 mL	2.4488 mL
	50 mM	0.0784 mL	0.3918 mL	0.7836 mL	1.9590 mL
	60 mM	0.0653 mL	0.3265 mL	0.6530 mL	1.6325 mL
	80 mM	0.0490 mL	0.2449 mL	0.4898 mL	1.2244 mL
	100 mM	0.0392 mL	0.1959 mL	0.3918 mL	0.9795 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.