2. Immunology/Inflammation Apoptosis
  3. Toll-like Receptor (TLR) AIM2 Pyroptosis Interleukin Related
  4. ODN TTAGGG

ODN TTAGGG  (Synonyms: ODN A151)

製品番号: HY-150751 純度: 93.96%
COA 取扱説明書 Technical Support

ODN TTAGGG (ODN A151), an inhibitory oligonucleotide (ODN), is a TLR9, AIM2, and cGAS antagonist. ODN TTAGGG inhibits AIM2 inflammasome activation and cGAS activation through competition with DNA. ODN TTAGGG blocks AIM2-mediated Pyroptosis and inhibits IL-18 production. ODN TTAGGG has immunosuppressive effects and can be used in research on related autoimmune diseases such as lupus erythematosus. ODN TTAGGG sequence: 5'-T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G-3'.

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DNA, d(P-thio)(T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G)

ODN TTAGGG 構造式

CAS 番号 : 1801724-76-4

容量 価格（税別） 在庫状況 数量
1 mg $160 在庫あり
5 mg $440 在庫あり
10 mg $686 在庫あり
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Based on 3 publication(s) in Google Scholar

Other Forms of ODN TTAGGG:

ODN TTAGGG 関連抗体

Top Publications Citing Use of Products

Toll-like Receptor (TLR) アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

Interleukin Related アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

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製品説明

ODN TTAGGG (ODN A151), an inhibitory oligonucleotide (ODN), is a TLR9, AIM2, and cGAS antagonist. ODN TTAGGG inhibits AIM2 inflammasome activation and cGAS activation through competition with DNA. ODN TTAGGG blocks AIM2-mediated Pyroptosis and inhibits IL-18 production. ODN TTAGGG has immunosuppressive effects and can be used in research on related autoimmune diseases such as lupus erythematosus[1][2][3]. ODN TTAGGG sequence: 5'-T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G-3'.

IC50 & Target[1][2][3]

IL-18

 

体外実験

ODN TTAGGG reduces IFNβ responses to both viruses (HSV-1 or MCMV) in BMDC and BMDM[1].
ODN TTAGGG suppresses IL-18 secretion in response to poly(dA:dT) but not nigericin in BMDC[1].
ODN TTAGGG (6 µg) is capable of interacting with AIM2 even in the absence of an activating stimulus[1].
ODN TTAGGG blocks inflammasome assembly in an AIM2-citrine reporter cell line[1].
ODN TTAGGG (0.3 μM) blocks cGAS-mediated type I IFN response induced by cytosolic DNA in THP-1 cells[2].
ODN TTAGGG (0.3-3 μM; 7 days) inhibits autonomous type I IFN response in TREX1 deficient THP-1 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ODN TTAGGG 関連抗体
体内実験

ODN TTAGGG (50 µg; instilled into the lungs) significantly reduces the pulmonary inflammation induced by mechanical ventilation in mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MV-induced pulmonary inflammation mice[3]
Dosage: 50 µg in 20 µL of PBS
Administration: instilled into the lungs
Result: Resulted in a 3-5 fold decrease in the number of PMN migrating into the lung parenchyma and BAL of mice after MV.
Normalized MV-induced changes in BAL and lung macrophage frequency.
分子量

7944.30

CAS 番号
Appearance

Solid

Color

White to off-white

Sequence

DNA, d(P-thio)(T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G)
SMILES

[DNA, d(P-thio)(T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G)]
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
体外: 

H2O : ≥ 20 mg/mL (2.52 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.1259 mL 0.6294 mL 1.2588 mL
5 mM --- --- ---
10 mM --- --- ---
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
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This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

純度: 99.87%

COA (239 KB) LCMS (1135 KB)

取扱説明書 (2242 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.1259 mL 0.6294 mL 1.2588 mL 3.1469 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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ODN TTAGGG Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ODN TTAGGG1801724-76-4ODN A151ODN A 151ODN A-151Toll-like Receptor (TLR)AIM2PyroptosisInterleukin RelatedAbsent in melanoma 2Interferon-inducible protein AIM2PYHINILTLR antagonistcGASoligonucleotideimmunosuppressivelupus erythematosusInhibitorinhibitorinhibit

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ODN TTAGGG
製品番号:
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