1801724-76-4
Chemical Structure
ODN TTAGGG
Synonym(s): ODN A151
- CAS No.: 1801724-76-4
- Formula:N/A
- Molecular Weight:7944.30
IUPAC Name: ethyl 6-fluoro-3-hydroxy-2-oxo-1,2-dihydroquinoline-4-carboxylate
SMILES: [DNA, d(P-thio)(T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G)]
Biological Activity: ODN TTAGGG (ODN A151), an inhibitory oligonucleotide (ODN), is a TLR9, AIM2, and cGAS antagonist. ODN TTAGGG inhibits AIM2 inflammasome activation and cGAS activation through competition with DNA. ODN TTAGGG blocks AIM2-mediated Pyroptosis and inhibits IL-18 production. ODN TTAGGG has immunosuppressive effects and can be used in research on related autoimmune diseases such as lupus erythematosus[1][2][3]. ODN TTAGGG sequence: 5'-T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G-3'.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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ODN TTAGGG | 93.96% | ODN TTAGGG (ODN A151), an inhibitory oligonucleotide (ODN), is a TLR9, AIM2, and cGAS antagonist. ODN TTAGGG inhibits AIM2 inflammasome activation and cGAS activation through competition with DNA. ODN TTAGGG blocks AIM2-mediated Pyroptosis and inhibits IL-18 production. ODN TTAGGG has immunosuppressive effects and can be used in research on related autoimmune diseases such as lupus erythematosus. ODN TTAGGG sequence: 5'-T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G-3'. | ||||||||||||||||||||
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- [1]. John J Kaminski, et al. Synthetic oligodeoxynucleotides containing suppressive TTAGGG motifs inhibit AIM2 inflammasome activation. J Immunol. 2013 Oct 1;191(7):3876-83. [Content Brief]
- [2]. Folkert Steinhagen, et al. Suppressive oligodeoxynucleotides containing TTAGGG motifs inhibit cGAS activation in human monocytes. Eur J Immunol. 2018 Apr;48(4):605-611. [Content Brief]
- [3]. Scheiermann J, et al. Suppressive oligonucleotides inhibit inflammation in a murine model of mechanical ventilator induced lung injury. J Thorac Dis. 2016 Sep;8(9):2434-2443. [Content Brief]
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