ODN TTAGGG
Based on 5 publication(s) in Google Scholar
ODN TTAGGG (ODN A151), an inhibitory oligonucleotide (ODN), is a TLR9, AIM2, and cGAS antagonist. ODN TTAGGG inhibits AIM2 inflammasome activation and cGAS activation through competition with DNA. ODN TTAGGG blocks AIM2-mediated Pyroptosis and inhibits IL-18 production. ODN TTAGGG has immunosuppressive effects and can be used in research on related autoimmune diseases such as lupus erythematosus. ODN TTAGGG sequence: 5'-T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G-3'.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 93.96%
- CAS 番号: 1801724-76-4
- 分子量:7944.30
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保管条件:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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MedChemExpress（MCE）の使用を引用している文献 ODN TTAGGG
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生物活性
製品説明
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IL-18 |
体外実験
ODN TTAGGG reduces IFNβ responses to both viruses (HSV-1 or MCMV) in BMDC and BMDM[1].
ODN TTAGGG suppresses IL-18 secretion in response to poly(dA:dT) but not nigericin in BMDC[1].
ODN TTAGGG (6 µg) is capable of interacting with AIM2 even in the absence of an activating stimulus[1].
ODN TTAGGG blocks inflammasome assembly in an AIM2-citrine reporter cell line[1].
ODN TTAGGG (0.3 μM) blocks cGAS-mediated type I IFN response induced by cytosolic DNA in THP-1 cells[2].
ODN TTAGGG (0.3-3 μM; 7 days) inhibits autonomous type I IFN response in TREX1 deficient THP-1 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:MV-induced pulmonary inflammation mice[3]
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Dosage:50 µg in 20 µL of PBS
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Administration:instilled into the lungs
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Result:Resulted in a 3-5 fold decrease in the number of PMN migrating into the lung parenchyma and BAL of mice after MV.
Normalized MV-induced changes in BAL and lung macrophage frequency.
化学情報
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CAS 番号 1801724-76-4
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性状 Solid
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分子量 7944.30
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Color White to off-white
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SMILES
[DNA, d(P-thio)(T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G)]
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別名
ODN A151
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配列
DNA, d(P-thio)(T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G)
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (5)
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Journal Impact Factor
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Most Recent
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Cell Mol Biol Lett
Fusobacterium nucleatum-derived extracellular vesicles carrying virulence factor DNA trigger AIM2 inflammasome activation to facilitate UC progression. [Abstract]2025 Nov 17;30(1):138. PMID: 41249954 -
Cell Commun Signal
Neutrophil extracellular traps facilitate liver inflammation/fibrosis progression by entering macrophages and triggering AIM2 inflammasome-dependent pyroptosis. [Abstract]2024 Nov 20;22(1):556. PMID: 39568027 -
Phytother Res
Resveratrol Alleviates Inflammation in Polycystic Ovary Syndrome by Inhibiting Absent in Melanoma 2 Expression. [Abstract]2026 May 12. PMID: 42118129 -
Biochem Pharmacol
IFN-γ-induced AIM2-PANoptosis in granulosa cells leads to ovulatory dysfunction in polycystic ovary syndrome. [Abstract]2026 May 12;250(Pt 2):118039. PMID: 42114679
溶剤 & 溶解度
体外:
H2O : ≥ 20 mg/mL (2.52 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (270 KB)
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SDS (251 KB)
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- Deutsch - DE (251 KB)
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- Español - ES (251 KB)
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- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2242 KB)
参考文献
[1]. John J Kaminski, et al. Synthetic oligodeoxynucleotides containing suppressive TTAGGG motifs inhibit AIM2 inflammasome activation. J Immunol. 2013 Oct 1;191(7):3876-83. [Content Brief]
[2]. Folkert Steinhagen, et al. Suppressive oligodeoxynucleotides containing TTAGGG motifs inhibit cGAS activation in human monocytes. Eur J Immunol. 2018 Apr;48(4):605-611. [Content Brief]
[3]. Scheiermann J, et al. Suppressive oligonucleotides inhibit inflammation in a murine model of mechanical ventilator induced lung injury. J Thorac Dis. 2016 Sep;8(9):2434-2443. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.1259 mL | 0.6294 mL | 1.2588 mL | 3.1469 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
ODN TTAGGG 関連分類
HY-150751 関連分類
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