2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. Oxybuprocaine

Oxybuprocaine  (Synonyms: Benoxinate; Novesinol; Oxybucaine)

Cat. No.: HY-B1288A Pureza: 99.93%
COA
SDS
Instrucciones de manejo Technical Support

Oxybuprocaine is a short-acting ester anesthetic. Oxybuprocaine binds to sodium channels and reversibly stabilizes neuronal membranes. Oxybuprocaine has cutaneous analgesic properties. Oxybuprocaine is less potent than Bupivacaine (HY-B0405) at producing central nervous system and cardiovascular toxicity. Oxybuprocaine can be used in ophthalmology and otolaryngology.

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Oxybuprocaine

Oxybuprocaine Estructura química

No. CAS : 99-43-4

Tamaño Precio Stock Cantidad
Solid or liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 En stock
Solution
10 mM * 1 mL in DMSO En stock
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500 mg   Obtener un presupuesto  

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Other Forms of Oxybuprocaine:

Oxybuprocaine Related Antibodies

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Descripciòn

Oxybuprocaine is a short-acting ester anesthetic. Oxybuprocaine binds to sodium channels and reversibly stabilizes neuronal membranes. Oxybuprocaine has cutaneous analgesic properties. Oxybuprocaine is less potent than Bupivacaine (HY-B0405) at producing central nervous system and cardiovascular toxicity. Oxybuprocaine can be used in ophthalmology and otolaryngology[1][2][3][4][5][6].

In Vivo

Oxybuprocaine (0.4%; topical instillation into eyes) hydrochloride ensures good conductivity and local anesthesia when applied before electrical stimulation in the maximal electroshock (MES) and 6-Hz seizure models in mice[3].
Oxybuprocaine (6.67 μmol/kg/min; i.v.) hydrochloride produces slower decreases in mean arterial blood pressure and heart rate compared with Bupivacaine (HY-B0405) in Sprague-Dawley rats, and the time to induce seizure, apnea, and impending death is longer than that of Bupivacaine[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Peso molecular

308.42

Fòrmula

C17H28N2O3
No. CAS
Appearance

Viscous Liquid

Color

Colorless to light yellow

SMILES

O=C(OCCN(CC)CC)C1=CC=C(N)C(OCCCC)=C1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvente y solubilidad
In Vitro: 

DMSO : ≥ 125 mg/mL (405.29 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2423 mL 16.2117 mL 32.4233 mL
5 mM 0.6485 mL 3.2423 mL 6.4847 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureza y Documentación

Purity: 99.93%

SDS (394 KB)

COA (243 KB) HNMR (262 KB) LCMS (83 KB)

Instrucciones de manejo (2659 KB)
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2423 mL 16.2117 mL 32.4233 mL 81.0583 mL
5 mM 0.6485 mL 3.2423 mL 6.4847 mL 16.2117 mL
10 mM 0.3242 mL 1.6212 mL 3.2423 mL 8.1058 mL
15 mM 0.2162 mL 1.0808 mL 2.1616 mL 5.4039 mL
20 mM 0.1621 mL 0.8106 mL 1.6212 mL 4.0529 mL
25 mM 0.1297 mL 0.6485 mL 1.2969 mL 3.2423 mL
30 mM 0.1081 mL 0.5404 mL 1.0808 mL 2.7019 mL
40 mM 0.0811 mL 0.4053 mL 0.8106 mL 2.0265 mL
50 mM 0.0648 mL 0.3242 mL 0.6485 mL 1.6212 mL
60 mM 0.0540 mL 0.2702 mL 0.5404 mL 1.3510 mL
80 mM 0.0405 mL 0.2026 mL 0.4053 mL 1.0132 mL
100 mM 0.0324 mL 0.1621 mL 0.3242 mL 0.8106 mL
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Oxybuprocaine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Oxybuprocaine99-43-4Benoxinate Novesinol OxybucaineSodium ChannelNa channelsNa+ channelsophthalmologyotolaryngologycutaneous analgesiaInhibitorinhibitorinhibit

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Oxybuprocaine
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