1. Membrane Transporter/Ion Channel
  2. Sodium Channel
  3. Oxybuprocaine hydrochloride

Oxybuprocaine hydrochloride (Synonyms: Benoxinate hydrochloride)

Cat. No.: HY-B1288 Purity: ≥98.0%
Handling Instructions

Oxybuprocaine hydrochloride (Benoxinate hydrochloride) reversibly blocks sodium channels and prevents propagation of painful nerve impulses in the cornea, conjunctiva, and sclera. Oxybuprocaine hydrochloride is used especially in ophthalmology and otolaryngology.

For research use only. We do not sell to patients.

Oxybuprocaine hydrochloride Chemical Structure

Oxybuprocaine hydrochloride Chemical Structure

CAS No. : 5987-82-6

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 99 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 99 In-stock
Estimated Time of Arrival: December 31
Solid
50 mg USD 90 In-stock
Estimated Time of Arrival: December 31
100 mg USD 150 In-stock
Estimated Time of Arrival: December 31
250 mg USD 290 In-stock
Estimated Time of Arrival: December 31
500 mg   Get quote  
1 g   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Oxybuprocaine hydrochloride (Benoxinate hydrochloride) reversibly blocks sodium channels and prevents propagation of painful nerve impulses in the cornea, conjunctiva, and sclera. Oxybuprocaine hydrochloride is used especially in ophthalmology and otolaryngology[1][2][3].

In Vivo

Oxybuprocaine hydrochloride (Benoxinate hydrochloride; 27.6, 51.7, 103.5, 413.9 μg; s.c.) provides a dose-dependent block to pinpricks in rats[1].
Oxybuprocaine hydrochloride (27.6 μg) produces 100% of sensory/nociceptive block[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (203-253 g)[1]
Dosage: 27.6, 51.7, 103.5, 413.9 μg
Administration: SC
Result: Provided a dose-dependent block to pinpricks.
Clinical Trial
Molecular Weight

344.88

Formula

C₁₇H₂₉ClN₂O₃

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (289.96 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8996 mL 14.4978 mL 28.9956 mL
5 mM 0.5799 mL 2.8996 mL 5.7991 mL
10 mM 0.2900 mL 1.4498 mL 2.8996 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.25 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.25 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.25 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Oxybuprocaine hydrochloride
Cat. No.:
HY-B1288
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