Polymyxin B

Name: Polymyxin B
Brand: MedChemExpress
SKU: HY-149179
Rating: 5.0 (23 reviews)

Cat. No.: HY-149179 Purity: 92.99%: Data Sheet
COA

SDS
Handling Instructions
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Technical Support

Polymyxin B is an antibiotic. Polymyxin B inhibits Gram-negative infections by binding to the LPS of the bacterial wall with high affinity. Polymyxin B neutralizes the effect of endotoxin. Polymyxin B induces bacterial death by increasing its permeability. Polymyxin B is used in endotoxemia research.

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CAS No. : 1404-26-8

사이즈	재고	수량
무료 샘플 (0.1 - 0.2 mg)	지금 신청하기
100 mg	해외재고보유	Estimated Time of Arrival: December 31
500 mg	해외재고보유	Estimated Time of Arrival: December 31
1 g	견적 받기
5 g	견적 받기

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This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 23 publication(s) in Google Scholar

Other Forms of Polymyxin B:

Polymyxin B Sulfate In-stock

23 Publications Citing Use of MCE Polymyxin B

Cell Proliferation/Viability Assay

Gel Electrophoresis

Microbiological Assay

Bio/Physico-chemical Assay

Cell Imaging/Staining

Histological Imaging/Staining

In Vivo Efficacy Study

: Polymyxin B purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2025 Jul 1;23(1):465. [Abstract]; Electrophoretic migration of Td and the Polymyxin B@Td nanocomplex at different gradient mixture ratios (Polymyxin B: Td = 10:1, 50:1, and 100:1).

: Polymyxin B purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2025 Jul 1;23(1):465. [Abstract]; Analysis of the zeta potentials of Polymyxin B, Td, and the Polymyxin B@Td nanocomplex.

: Polymyxin B purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2025 Jul 1;23(1):465. [Abstract]; Penetration of free or Td-bound Polymyxin B into a bacterial biofilm, as characterized by CLSM (blue: Hoechst33342-stained bacteria; green: FITC-labeled Td; red: Cy5-labeled Polymyxin B). Scale bar: 50 μm.

: Polymyxin B purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2025 Jul 1;23(1):465. [Abstract]; SEM analysis of biofilm structural disruption by Polymyxin B and Polymyxin B@Td. Red arrows: biofilm matrix components. Red dotted-line square: representative dead bacteria. Scale bar: 5–3 μm.

: Polymyxin B purchased from MedChemExpress. Usage Cited in: J Control Release. 2025 May 30:113907. [Abstract]; Antimicrobial effects of PMB-LNPs. MIC and Polymyxin B values of Polymyxin B -LNPs or free Polymyxin B against E. coli, A. baumannii.

: Polymyxin B purchased from MedChemExpress. Usage Cited in: Mater Today Bio. 2025 Feb 18:31:101590.; The cytotoxicity assessment of PEG-pHSA@PMB nanoparticles. The toxicity of Polymyxin B Sulfate (PMB, 24 h), PEG-pHSA@PMB, and PEG-pHSA to HBE cells was detected by the CCK-8 kit.

: Polymyxin B purchased from MedChemExpress. Usage Cited in: Mater Today Bio. 2025 Feb 18:31:101590.; Polymyxin B Sulfate, 4 μg/mL. The bacteriostasis curves of the drugs. The OD600 value of the CRKP suspension was determined at different times.

: Polymyxin B purchased from MedChemExpress. Usage Cited in: Mater Today Bio. 2025 Feb 18:31:101590.; The load of CRKP in the lungs of mice that inhaled different drugs. The bacterial load of CRKP in the lungs of pneumonia mice treated with inhaled drugs (equivalent to 4 mg/kg loaded Polymyxin B Sulfate) was measured by the bacterial plate counting method.

: Polymyxin B purchased from MedChemExpress. Usage Cited in: Mater Today Bio. 2025 Feb 18:31:101590.; PEG-pHSA@PMB (4 mg/kg loaded Polymyxin B Sulfate). HE staining of lung sections of CRKP pneumonia mice treated with different drugs. The scale bar is 50 μm.

: Polymyxin B purchased from MedChemExpress. Usage Cited in: Mater Today Bio. 2025 Feb 18:31:101590.; PEG-pHSA@PMB (4 mg/kg loaded Polymyxin B Sulfate). The statistical chart of lung injury score by HE staining of lung tissue in each group, n = 9.

: Polymyxin B purchased from MedChemExpress. Usage Cited in: Mater Today Bio. 2025 Feb 18:31:101590.; HE staining of different tissues in mice treated with different drugs. The HE staining results of the lungs, kidneys, brains, hearts, livers, and spleens of ICR mice were examined after inhaling 30 μL of different drugs (equivalent to 8 mg/kg loaded Polymyxin B Sulfate) three times daily for 3 days, n = 5. The scale bar is 100 μm.

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

In Vitro

Polymyxin B (10 μg/mL, 6 h) decreases the TNF-α and IL-10 production in Human peripheral blood mononuclear cells (PBMC) ^[3].
Polymyxin B shows antibacterial activities with MICs of 0.5 mg/l for E. coli strain IH3080^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Polymyxin B (0.5-120 mg/kg; s.c.) shows antibacterial activities in thigh or lung infection mouse model^[2].
Polymyxin B (2 mg/kg, s.c.) shows potent in mouse bactericidal effect against E. coli strain IH3080^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Eight-week-old, 24-30 g, female Swiss mice^[2]
Dosage:	0.5-120 mg/kg for thigh infection model; 5-120 mg/kg for lung infection model
Administration:	S.c.
Result:	Showed antibacterial activities for three K. pneumoniae strains.

Animal Model:	7-9 weeks, female NMRI mice (E. coli IH3080)^[3]
Dosage:	2 mg/kg
Administration:	S.c.
Result:	Decreased the bacterial count in a dose dependent manner.

Clinical Trial

CAS No.

1404-26-8

Appearance

Solid

Color

White to light yellow

SMILES

[Polymyxin B]

선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

0.5 M HCl : ≥ 50 mg/mL

H₂O : 33.33 mg/mL (ultrasonic and adjust pH to 2 with HCl)

H₂O : 33.33 mg/mL (ultrasonic and adjust pH to 2 with 1 M HCl)

*"≥" means soluble, but saturation unknown.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

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Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

순도&문서

Purity: 92.99%

Select Batch:

Data Sheet (271 KB) SDS (393 KB)

COA (243 KB) RP-HPLC (214 KB)

Handling Instructions (2659 KB)

References

[1]. Danner RL, et al. Purification, toxicity, and antiendotoxin activity of polymyxin B nonapeptide. Antimicrob Agents Chemother. 1989 Sep;33(9):1428-34. [Content Brief]

[2]. Landersdorfer CB, et al. Pharmacokinetics/pharmacodynamics of systemically administered polymyxin B against Klebsiella pneumoniae in mouse thigh and lung infection models. J Antimicrob Chemother. 2018 Feb 1;73(2):462-468. [Content Brief]

[3]. Vingsbo Lundberg C, et al. Novel polymyxin derivatives are effective in treating experimental Escherichia coli peritoneal infection in mice. J Antimicrob Chemother. 2010 May;65(5):981-5. [Content Brief]

[4]. Cardoso LS, et al.Polymyxin B as inhibitor of LPS contamination of Schistosoma mansoni recombinant proteins in human cytokine analysis. Microb Cell Fact. 2007 Jan 3;6:1. [Content Brief]

Polymyxin B Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Polymyxin B1404-26-8AntibioticBacterialEndotoxemiaGram-negative infectionLPSNephrotoxicitySprague-Dawley ratsE. coliPBMCInhibitorinhibitorinhibit

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Polymyxin B

고객리뷰

Other Forms of Polymyxin B:

Polymyxin B Related Antibodies

23 Publications Citing Use of MCE Polymyxin B

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•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Antibiotic Isoform Specific Products:

Biological Activity

순도&문서

References

고객리뷰

Polymyxin B Related Antibodies

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Polymyxin B Related Classifications

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