Quinizarin (Synonyms: 1,4-Dihydroxyanthraquinone)

Name: Quinizarin
Brand: MedChemExpress
SKU: HY-D0226
Rating: 4.5 (0 reviews)

Cat. No.: HY-D0226 Pureza: 98.84%: Ficha de datos
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Quinizarin (1,4-Dihydroxyanthraquinone), a part of the anticancer agents such as Doxorubicin, Daunorubicin, and Adriamycin, interacts with DNA by intercalating mode (K_d=86.1 μM). Quinizarin is used as a fungicide and pesticide chemical and has shown the ability to inhibit tumor cell growth.

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Quinizarin Estructura química

No. CAS : 81-64-1

Tamaño	Stock	Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	En stock	Estimated Time of Arrival: December 31
Solid
100 g	En stock	Estimated Time of Arrival: December 31
250 g	En stock	Estimated Time of Arrival: December 31
500 g	En stock	Estimated Time of Arrival: December 31
1 kg	En stock	Estimated Time of Arrival: December 31

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Other Forms of Quinizarin:

Quinizarin (Standard) Obtener un presupuesto

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Descripciòn

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	> 200 3 Compound: Quinizarin	Inhibition of topoisomerase 2 in human A549 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay Inhibition of topoisomerase 2 in human A549 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay	[PMID: 30846253]
A-431	IC₅₀	>30 6 Compound: DHAQ	Inhibitory concentration required against A 431 human epidermoid carcinoma cell line Inhibitory concentration required against A 431 human epidermoid carcinoma cell line	[PMID: 11354370]
A-431	IC₅₀	> 30 6 Compound: DHAQ	Inhibitory concentration required against A 431 human epidermoid carcinoma cell line Inhibitory concentration required against A 431 human epidermoid carcinoma cell line	[PMID: 11354370]
Ca-Ski	IC₅₀	> 10 3 Compound: 1	Cytotoxicity against human CaSki cells after 72 hrs by MTT assay Cytotoxicity against human CaSki cells after 72 hrs by MTT assay	[PMID: 24657570]
A549	IC₅₀	> 200 3 Compound: Quinizarin	Inhibition of topoisomerase 2 in human A549 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay Inhibition of topoisomerase 2 in human A549 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay	[PMID: 30846253]
A549	IC₅₀	>200 3 Compound: Quinizarin	Inhibition of topoisomerase 2 in human A549 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay Inhibition of topoisomerase 2 in human A549 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay	[PMID: 30846253]
HeLa	IC₅₀	> 200 3 Compound: Quinizarin	Inhibition of topoisomerase 2 in human HeLa cells assessed as reduction in cell growth measured after 72 hrs by MTT assay Inhibition of topoisomerase 2 in human HeLa cells assessed as reduction in cell growth measured after 72 hrs by MTT assay	[PMID: 30846253]
B16	IC₅₀	>30 6 Compound: DHAQ	Inhibitory concentration against B16 murine melanoma cell line Inhibitory concentration against B16 murine melanoma cell line	[PMID: 11354370]
B16	IC₅₀	> 30 6 Compound: DHAQ	Inhibitory concentration against B16 murine melanoma cell line Inhibitory concentration against B16 murine melanoma cell line	[PMID: 11354370]
Ca-Ski	IC₅₀	>10 3 Compound: 1	Cytotoxicity against human CaSki cells after 72 hrs by MTT assay Cytotoxicity against human CaSki cells after 72 hrs by MTT assay	[PMID: 24657570]
HepG2	IC₅₀	> 200 3 Compound: Quinizarin	Inhibition of topoisomerase 2 in human HepG2 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay Inhibition of topoisomerase 2 in human HepG2 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay	[PMID: 30846253]
Ca-Ski	IC₅₀	> 10 3 Compound: 1	Cytotoxicity against human CaSki cells after 72 hrs by MTT assay Cytotoxicity against human CaSki cells after 72 hrs by MTT assay	[PMID: 24657570]
L02	IC₅₀	> 200 3 Compound: Quinizarin	Cytotoxicity against human L02 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay Cytotoxicity against human L02 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay	[PMID: 30846253]
HCT-116	IC₅₀	>30 6 Compound: DHAQ	Inhibitory concentration against HCT 116 human colon cancer cell line Inhibitory concentration against HCT 116 human colon cancer cell line	[PMID: 11354370]
MCF7	IC₅₀	> 200 3 Compound: Quinizarin	Inhibition of topoisomerase 2 in human MCF7 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay Inhibition of topoisomerase 2 in human MCF7 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay	[PMID: 30846253]
HeLa	IC₅₀	>200 3 Compound: Quinizarin	Inhibition of topoisomerase 2 in human HeLa cells assessed as reduction in cell growth measured after 72 hrs by MTT assay Inhibition of topoisomerase 2 in human HeLa cells assessed as reduction in cell growth measured after 72 hrs by MTT assay	[PMID: 30846253]
HCT-116	IC₅₀	> 30 6 Compound: DHAQ	Inhibitory concentration against HCT 116 human colon cancer cell line Inhibitory concentration against HCT 116 human colon cancer cell line	[PMID: 11354370]
MDA-MB-231	IC₅₀	> 200 3 Compound: Quinizarin	Inhibition of topoisomerase 2 in human MDA-MB-231 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay Inhibition of topoisomerase 2 in human MDA-MB-231 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay	[PMID: 30846253]
HepG2	IC₅₀	>200 3 Compound: Quinizarin	Inhibition of topoisomerase 2 in human HepG2 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay Inhibition of topoisomerase 2 in human HepG2 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay	[PMID: 30846253]
HeLa	IC₅₀	> 200 3 Compound: Quinizarin	Inhibition of topoisomerase 2 in human HeLa cells assessed as reduction in cell growth measured after 72 hrs by MTT assay Inhibition of topoisomerase 2 in human HeLa cells assessed as reduction in cell growth measured after 72 hrs by MTT assay	[PMID: 30846253]
L02	IC₅₀	>200 3 Compound: Quinizarin	Cytotoxicity against human L02 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay Cytotoxicity against human L02 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay	[PMID: 30846253]
MCF7	IC₅₀	>200 3 Compound: Quinizarin	Inhibition of topoisomerase 2 in human MCF7 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay Inhibition of topoisomerase 2 in human MCF7 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay	[PMID: 30846253]
HepG2	IC₅₀	> 200 3 Compound: Quinizarin	Inhibition of topoisomerase 2 in human HepG2 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay Inhibition of topoisomerase 2 in human HepG2 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay	[PMID: 30846253]
MDA-MB-231	IC₅₀	>200 3 Compound: Quinizarin	Inhibition of topoisomerase 2 in human MDA-MB-231 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay Inhibition of topoisomerase 2 in human MDA-MB-231 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay	[PMID: 30846253]
L02	IC₅₀	> 200 3 Compound: Quinizarin	Cytotoxicity against human L02 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay Cytotoxicity against human L02 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay	[PMID: 30846253]
MCF7	IC₅₀	> 200 3 Compound: Quinizarin	Inhibition of topoisomerase 2 in human MCF7 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay Inhibition of topoisomerase 2 in human MCF7 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay	[PMID: 30846253]
MDA-MB-231	IC₅₀	> 200 3 Compound: Quinizarin	Inhibition of topoisomerase 2 in human MDA-MB-231 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay Inhibition of topoisomerase 2 in human MDA-MB-231 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay	[PMID: 30846253]

In Vitro

1,4-Dihydroxyanthraquinone (1,4-DHAQ, a fluorophore) doped cellulose (CL) (denoted as 1,4-DHAQ@CL) microporous nanofiber film has been achieved via simple electrospinning and subsequent deacetylating, and used for highly sensitive and selective fluorescence detection of Cu²⁺ in aqueous solution^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Peso molecular

240.21

Fòrmula

C₁₄H₈O₄

No. CAS

81-64-1

Appearance

Solid

Color

Orange to red

Emission (Em)

456

Excitation (Ex)

424

SMILES

O=C1C2=C(C=CC=C2)C(C3=C(O)C=CC(O)=C13)=O

Structure Classification

Initial Source

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvente y solubilidad

In Vitro:

DMSO : 3.33 mg/mL (13.86 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.1630 mL	20.8151 mL	41.6302 mL
5 mM	0.8326 mL	4.1630 mL	8.3260 mL
10 mM	0.4163 mL	2.0815 mL	4.1630 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad
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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Pureza y Documentación

Purity: 98.84%

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Ficha de datos (279 KB) SDS (458 KB)

COA (256 KB) HNMR (114 KB) RP-HPLC (249 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Verebová V, et al. Anthraquinones quinizarin and danthron unwind negatively supercoiled DNA and lengthen linear DNA. Biochem Biophys Res Commun. 2014;444(1):50-55. [Content Brief]

[2]. Dominic Cheuk, et al. Investigation into solid and solution properties of quinizarin.

[3]. Wang M, et al. Electrospun 1,4-DHAQ-doped cellulose nanofiber films for reusable fluorescence detection of trace Cu2+ and further for Cr3+. Environ Sci Technol. 2012;46(1):367-373. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.1630 mL	20.8151 mL	41.6302 mL	104.0756 mL
	5 mM	0.8326 mL	4.1630 mL	8.3260 mL	20.8151 mL
	10 mM	0.4163 mL	2.0815 mL	4.1630 mL	10.4076 mL

Quinizarin Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Quinizarin81-64-11,4-DihydroxyanthraquinoneDNA/RNA SynthesisFungaltumorcellgrowthDNAfungicidepesticideInhibitorinhibitorinhibit

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Quinizarin (Synonyms: 1,4-Dihydroxyanthraquinone)

Revisión del cliente

Other Forms of Quinizarin:

Quinizarin Related Antibodies

Recomendaciones destacadas

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Ver todos los productos específicos de isoformas DNA/RNA Synthesis:

Actividad biológica

Pureza y Documentación

Referencias

Revisión del cliente

Quinizarin Related Antibodies

Calculadora de molaridad

Calculadora de dilución

Complete Stock Solution Preparation Table

Quinizarin Related Classifications

Keywords:

Productos vistos recientemente:

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