2. Anti-infection GPCR/G Protein
  3. Influenza Virus G protein-coupled Bile Acid Receptor 1 Adenosine Receptor
  4. SCH-202676

SCH-202676 is an allosteric modulator of G protein-coupled receptors (GPCRs) and adenosine receptor (AR). SCH-202676 has antiviral activity and inhibits 3CLpro in a time-dependent manner with an IC50 value of 0.655 µM.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

SCH-202676

SCH-202676 화학구조

CAS No. : 70375-43-8

사이즈 가격 재고 수량
5 mg 해외재고보유
10 mg 해외재고보유
50 mg   견적 받기  
100 mg   견적 받기  

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

Other Forms of SCH-202676:

SCH-202676 Related Antibodies

Top Publications Citing Use of Products

View All Adenosine Receptor Isoform Specific Products:

View All Isoforms
Adenosine A1 receptor (A1R) Adenosine A2A receptor (A2AR) Adenosine A2B receptor (A2BR) Adenosine A3 receptor (A3R)

  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

SCH-202676 is an allosteric modulator of G protein-coupled receptors (GPCRs) and adenosine receptor (AR). SCH-202676 has antiviral activity and inhibits 3CLpro in a time-dependent manner with an IC50 value of 0.655 µM[1][2][3][4].

IC50 & Target[4]

Adenosine A3 receptor

 

In Vitro

SCH-202676 (compound 6a) (0.01-10 µM; 0, 5, 10 and 20 min) shows antiviral activity and inhibits 3CLpro in a time-dependent manner, with IC50 values of 0.409, 0.302, 0.206 and 0.191 µM for 0, 5, 10 and 20 min, respectively[1].
SCH-202676 (10 μM; 90 min) enhances the labelling of [35S]GTPγS in rat forebrain membranes[2].
SCH-202676 inhibits the agonist [3H]UK-14,304 (HY-B0659) and the antagonist [3H] Yohimbine (HY-12715) binding to the α2a adrenergic receptor[3].
SCH-202676 (10 μM) selectively accelerates agonist dissociation at adenosine A3 receptors, slows antagonist dissociation at adenosine Ai receptors, accelerates antagonist dissociation at adenosine AzA receptors[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SCH-202676 Related Antibodies
분자량

267.35

화학식

C15H13N3S
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

C/N=C1N=C(C2=CC=CC=C2)N(C3=CC=CC=C3)S/1
선적

Room temperature in continental US; may vary elsewhere.
보관
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
용액&용해도
In Vitro: 

DMSO : 100 mg/mL (374.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7404 mL 18.7021 mL 37.4041 mL
5 mM 0.7481 mL 3.7404 mL 7.4808 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
순도&문서
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.7404 mL 18.7021 mL 37.4042 mL 93.5104 mL
5 mM 0.7481 mL 3.7404 mL 7.4808 mL 18.7021 mL
10 mM 0.3740 mL 1.8702 mL 3.7404 mL 9.3510 mL
15 mM 0.2494 mL 1.2468 mL 2.4936 mL 6.2340 mL
20 mM 0.1870 mL 0.9351 mL 1.8702 mL 4.6755 mL
25 mM 0.1496 mL 0.7481 mL 1.4962 mL 3.7404 mL
30 mM 0.1247 mL 0.6234 mL 1.2468 mL 3.1170 mL
40 mM 0.0935 mL 0.4676 mL 0.9351 mL 2.3378 mL
50 mM 0.0748 mL 0.3740 mL 0.7481 mL 1.8702 mL
60 mM 0.0623 mL 0.3117 mL 0.6234 mL 1.5585 mL
80 mM 0.0468 mL 0.2338 mL 0.4676 mL 1.1689 mL
100 mM 0.0374 mL 0.1870 mL 0.3740 mL 0.9351 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

SCH-202676 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SCH-20267670375-43-8SCH202676SCH 202676Influenza VirusG protein-coupled Bile Acid Receptor 1Adenosine ReceptorG-protein coupled receptor 19GPCR19TGR5GPBAR1P1 receptorAntiviral activity[35S]GTPγS[3H]UK-14,304[3H] YohimbineInhibitorinhibitorinhibit

최근 본 상품:

온라인 문의

Your information is safe with us. * Required Fields.

상품명

  

Requested Quantity *

고객명 *

 

호칭

메일주소 *

 

전화번호 *

Department

 

회사명 *

City

도

Country or Region *

      

비고

대량구매 문의

Inquiry Information

상품명:
SCH-202676
Cat. No.:
HY-133862
수량:
MCE Japan Authorized Agent:

고객리뷰

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

상품명

  

Lot #

고객명 *

 

메일주소 *

전화번호

 

Department *

회사명 *

 

Country or Region *

비고

SAFETY DATA SHEET (SDS)

English - EN (251 KB) Français - FR (251 KB) Deutsch - DE (251 KB) Norwegian - NO (251 KB) Español - ES (251 KB) Swedish - SV (251 KB) Italian - IT (251 KB) Korean - KR (251 KB) Portuguese - PT (251 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.