2. Apoptosis NF-κB Metabolic Enzyme/Protease Immunology/Inflammation Cell Cycle/DNA Damage
  3. Apoptosis Reactive Oxygen Species (ROS) Polo-like Kinase (PLK)
  4. Scytonemin

Scytonemin is a hydrophobic alkaloid pigment that can be isolated from the outer sheath of cyanobacteria. Scytonemin has protective function against short-wave solar ultraviolet (UV) radiation, which can reduce the generation of reactive oxygen species (ROS) and the formation of DNA damage. Scytonemin also has anti-inflammatory and anti-proliferative activities, produces concentration-dependent inhibition (IC50=2.0 μM) of polo-like kinase 1 (PLK1)-mediated cdc25C phosphorylation, and plays an important role in regulating the G2/M transition in the cell cycle. It can be used in the research of cancer, acute inflammation and sunscreen cosmetics.

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Scytonemin

Scytonemin Estructura química

No. CAS : 152075-98-4

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Scytonemin Related Antibodies

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Descripciòn

Scytonemin is a hydrophobic alkaloid pigment that can be isolated from the outer sheath of cyanobacteria. Scytonemin has protective function against short-wave solar ultraviolet (UV) radiation, which can reduce the generation of reactive oxygen species (ROS) and the formation of DNA damage. Scytonemin also has anti-inflammatory and anti-proliferative activities, produces concentration-dependent inhibition (IC50=2.0 μM) of polo-like kinase 1 (PLK1)-mediated cdc25C phosphorylation, and plays an important role in regulating the G2/M transition in the cell cycle. It can be used in the research of cancer, acute inflammation and sunscreen cosmetics[1][2][3][4][5].

In Vitro

Scytonemin (3 μM; 24 h) inhibits the proliferation of human T-cell leukemia Jurkat cells (IC50= 7.8 μM) and induces apoptosis[4].
Scytonemin (100 nM-30 μM) has an inhibitory effect on PDGF-induced RSF and ECGF-induced HUVEC proliferation (IC50=1.5 μM; IC50=5.4 μM) [4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Scytonemin Related Antibodies

Cell Viability Assay[4]

Cell Line: human T-cell leukemia Jurkat cells
Concentration: 3 μM
Incubation Time: 24 h
Result: Induced 24% of cells to undergo apoptosis.
In Vivo

Scytonemin has a highly effective inhibitory effect (ED50=10 mg/kg) on Phorbol 12-myristate 13-acetate (HY-18739) induced ear inflammation in mice when administered parenterally[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Peso molecular

544.56

Fòrmula

C36H20N2O4
No. CAS
Appearance

Solid

Color

Brown to black

SMILES

O=C(/C1=C\C2=CC=C(O)C=C2)C(C(C(/C3=C\C4=CC=C(O)C=C4)=O)=C5C3=NC6=C5C=CC=C6)=C7C1=NC8=C7C=CC=C8
Structure Classification
Initial Source

Cyanobacteria
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvente y solubilidad
In Vitro: 

DMSO : 5 mg/mL (9.18 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8363 mL 9.1817 mL 18.3634 mL
5 mM 0.3673 mL 1.8363 mL 3.6727 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureza y Documentación

Purity: 99.53%

SDS (251 KB)

COA (259 KB) HNMR (295 KB) RP-HPLC (206 KB) LCMS (306 KB)

Instrucciones de manejo (2659 KB)
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8363 mL 9.1817 mL 18.3634 mL 45.9086 mL
5 mM 0.3673 mL 1.8363 mL 3.6727 mL 9.1817 mL
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Scytonemin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Scytonemin152075-98-4ApoptosisReactive Oxygen Species (ROS)Polo-like Kinase (PLK)Inhibitorinhibitorinhibit

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Nombre del producto:
Scytonemin
Cat. No.:
HY-112356
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