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Results for "

A2058 melanoma

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (2) Antibiotic (1) Apoptosis (1) DNA/RNA Synthesis (1) Environmental Pollutants (1) ERK (2) FOXO (1) Histone Methyltransferase (1) Influenza Virus (1) JNK (2) Mitochondrial Metabolism (1) Mitophagy (1) mTOR (2) p38 MAPK (2) PDK-1 (1) Phosphodiesterase (PDE) (2) PI3K (2) PROTACs (1) Reactive Oxygen Species (ROS) (1) Reference Standards (1) Ribosomal S6 Kinase (RSK) (1) RSV (1) Topoisomerase (1) Transmembrane Glycoprotein (1) Wnt (2) β-glucuronidase (1)
By Research Areas:	Cancer (12) Cardiovascular Disease (1) Infection (1) Inflammation/Immunology (3) Neurological Disease (2)

By Targets:

Akt (2)

Antibiotic (1)

Apoptosis (1)

DNA/RNA Synthesis (1)

Environmental Pollutants (1)

ERK (2)

FOXO (1)

Histone Methyltransferase (1)

Influenza Virus (1)

JNK (2)

Mitochondrial Metabolism (1)

Mitophagy (1)

mTOR (2)

p38 MAPK (2)

PDK-1 (1)

Phosphodiesterase (PDE) (2)

PI3K (2)

PROTACs (1)

Reactive Oxygen Species (ROS) (1)

Reference Standards (1)

Ribosomal S6 Kinase (RSK) (1)

RSV (1)

Topoisomerase (1)

Transmembrane Glycoprotein (1)

Wnt (2)

β-glucuronidase (1)

By Research Areas:

Cancer (12)

Cardiovascular Disease (1)

Infection (1)

Inflammation/Immunology (3)

Neurological Disease (2)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Targets Recommended: AIM2

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-123071

Box5 10+ Cited Publications	Wnt	Cancer
Box5 is a potent Wnt5a antagonist. Box5 inhibits Wnt5a signaling and inhibits Wnt5a-mediated Ca ²⁺ release. Box5 inhibits cell migration. Box5 has the potential for the research of melanoma .

HY-N7085

Citropten 5,7-Dimethoxycoumarin; Limettin	Environmental Pollutants ERK p38 MAPK JNK	Neurological Disease Inflammation/Immunology Cancer
Citropten (5, 7-dimethoxycoumarin) is one of the coumarin derivatives. Citropten is an effective oral anticancer agent. Citropten has anti-proliferative activity against A2058 and B16 melanoma cells. Citropten exerts anti-inflammatory effects through the NFκB and MAPK signaling pathways. Citropten acts as an antidepressant through heat shock protein-70, monoamine oxidase-A and inhibition of apoptosis .

HY-123071A

Box5 TFA 10+ Cited Publications	Wnt	Cancer
Box5 TFA is a potent Wnt5a antagonist. Box5 TFA inhibits Wnt5a signaling and inhibits Wnt5a-mediated Ca ²⁺ release. Box5 TFA inhibits cell migration. Box5 TFA has the potential for the research of melanoma .

HY-107767

Antibiotic DC 81 DC 81	Antibiotic Apoptosis DNA/RNA Synthesis	Cancer
Antibiotic DC 81 (DC 81), an antitumor antibiotic produced by Streptomyces species, is a PBD (pyrrolo[2,1-c][1,4]benzodiazepine). Antibiotic DC 81 is potent inhibitor of nucleic acid synthesis. Antibiotic DC 81 can recognize and bind to specific sequences of DNA and form a labile covalent adduct .

HY-N7085R

Citropten (Standard) 5,7-Dimethoxycoumarin (Standard); Limettin (Standard)	ERK JNK p38 MAPK Reference Standards	Neurological Disease Inflammation/Immunology Cancer
Citropten (Standard) is the analytical standard of Citropten. This product is intended for research and analytical applications. Citropten (5, 7-dimethoxycoumarin) is one of the coumarin derivatives. Citropten is an effective oral anticancer agent. Citropten has anti-proliferative activity against A2058 and B16 melanoma cells. Citropten exerts anti-inflammatory effects through the NFκB and MAPK signaling pathways. Citropten acts as an antidepressant through heat shock protein-70, monoamine oxidase-A and inhibition of apoptosis .

HY-16461

Solenopsin (-)-Solenopsin A	Akt Ribosomal S6 Kinase (RSK) PI3K PDK-1 FOXO Mitophagy Reactive Oxygen Species (ROS) Mitochondrial Metabolism	Cardiovascular Disease
Solenopsin ((-)-Solenopsin A) is an ATP-competitive and selective Akt-1 inhibitor with an IC₅₀ of 5-10 μM, and also acts as an RSK1 inhibitor. Solenopsin inhibits the activities of PDK1 in lipid rafts, downregulates PI3K, blocks PI3K-dependent generation of 3-phosphoinositides, and suppresses the phosphorylation of FOXO1a. Solenopsin induces Mitophagy and ROS production, reduces mitochondrial oxygen consumption, and exhibits antiproliferative and antiangiogenic activities. Solenopsin can be used in research related to hyperproliferative skin diseases and malignant diseases .

HY-174837

Topoisomerase IIα-IN-11	Topoisomerase	Cancer
Topoisomerase IIα-IN-11 (Compound 16h) is a potent Topoisomerase IIα inhibitor. Topoisomerase IIα-IN-11 shows significant inhibition on melanoma A2058 cell lines (IC₅₀ 3-6 μM). Topoisomerase IIα-IN-11 is promising for research of cancers (especially melanoma) .

HY-N17236

Forsyshiyanine A	β-glucuronidase Influenza Virus RSV	Infection
Foryshiyanine A is a triterpenoid alkaloid. Foryshiyanine A possesses anti-inflammatory activity, inhibiting the release of β-glucuronidase from rat polymorphonuclear leukocytes. Foryshiyanine A exhibits antiviral activity, with an EC₅₀ of 4.5 μM against respiratory syncytial virus (RSV) and an IC₅₀ of 7.3 μM against influenza A virus (H1N1). Foryshiyanine A reduces viral load by disrupting viral replication and entry. Foryshiyanine A may be used for the researches of inflammation and infection .

HY-134954

Palmitoleoyl 3-carbacyclic phosphatidic acid	Phosphodiesterase (PDE)	Cancer
Palmitoleoyl 3-carbacyclic phosphatidic acid (3ccPA 16:1) is an intermediately potent inhibitor of autotaxin (ATX) with an IC₅₀ of 620 nM. Palmitoleoyl 3-carbacyclic phosphatidic acid can be used for melanoma research .

HY-150061

NVP-BBD130	PI3K mTOR	Cancer
NVP-BBD130 is a potent, stable, ATP-competitive and orally active dual PI3K and mTOR inhibitor . NVP-BBD130 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-N16691

Acrovestone	Others	Inflammation/Immunology Cancer
Acrovestone (compound 4) is an Acronychia-type acetophenone dimer and a selective anticancer agent. Acrovestone has IC₅₀ values ??of 0.38 μM and 0.93 μM against A2058 melanoma cells and DU145 prostate cancer cells, respectively. Acrovestone shows low inhibitory activity against normal human dermal fibroblasts (NHDF), with an IC₅₀ >5 μM. Acrovestone can be used in anticancer research related to prostate cancer and melanoma. Acrovestone can be naturally extracted from the trunk bark of Acronychia pedunculata .

HY-P992392

JM1-24-3	Transmembrane Glycoprotein Akt mTOR	Cancer
JM1-24-3 is an anti-MUC18 mouse monoclonal antibody with a K_d value of 1.60e-9 M. JM1-24-3 reduces the phosphorylation levels of p-AKT (Ser473) and p-mTOR (Ser2448) in a time-dependent manner. JM1-24-3 exhibits anticancer activity against melanoma. JM1-24-3 can be used in studies related to metastatic melanoma .

HY-182275

PROTAC PRMT1 degrader-1	PROTACs Histone Methyltransferase	Cancer
PROTAC PRMT1 degrader-1 (compound 4) is a PRMT1 PROTAC degrader, with a DC₅₀ of 0.77 μM (MCF-7 cells). PROTAC PRMT1 degrader-1 recruits the CRBN E3 ubiquitin ligase to induce proteasome-dependent degradation of PRMT1; it also forms a ternary complex with PRMT1 and CRBN, promoting ubiquitination and subsequent proteasomal degradation of PRMT1. PROTAC PRMT1 degrader-1 reduces the level of asymmetric dimethylarginine in cancer cells, as well as the level of asymmetric dimethylation of arginine 3 on histone H4, while inhibiting the growth of various cancer cells. PROTAC PRMT1 degrader-1 can be used in the research of breast cancer and melanoma .

HY-119601

GRI918013	Phosphodiesterase (PDE)	Cancer
GRI918013 (compound 1) is a selective and competitive autotaxin (ATX/NPP2) inhibitor with anti-invasive and anti-metastatic activity. GRI918013 competitively binds to ATX, blocking lipid substrates such as lysophosphatidylcholine (LPC) from entering the ATX active site, thereby inhibiting ATX-mediated hydrolysis of LPC to lysophosphatidic acid (LPA), and consequently inhibiting ATX-LPA axis-related tumor cell invasion and metastasis. GRI918013 inhibits ATX-mediated hydrolysis of the LPL substrate FS-3 (IC₅₀=31.42 nM, K_i=12.98 nM). GRI918013 can be used in research on cancer invasion and metastasis, such as melanoma, and can also serve as a tool compound for ATX-LPA axis-related diseases such as fibrotic diseases, neuropathic pain, and cholestatic pruritus .

Cat. No.	Product Name	Target	Research Area