Forsyshiyanine A
Foryshiyanine A is a triterpenoid alkaloid. Foryshiyanine A possesses anti-inflammatory activity, inhibiting the release of β-glucuronidase from rat polymorphonuclear leukocytes. Foryshiyanine A exhibits antiviral activity, with an EC50 of 4.5 μM against respiratory syncytial virus (RSV) and an IC50 of 7.3 μM against influenza A virus (H1N1). Foryshiyanine A reduces viral load by disrupting viral replication and entry. Foryshiyanine A may be used for the researches of inflammation and infection.
For research use only. We do not sell to patients.
- CAS No.: 2767053-65-4
- Formula: C17H25NO
- Molecular Weight:259.39
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Forsyshiyanine A (Compound 1) (10 μM) inhibits the release of β-glucuronidase from rat polymorphonuclear leukocytes with an inhibition rate of 54.5%[1].
\r\nForsyshiyanine A exhibits potent anti-influenza A virus (H1N1) activity with an IC50 of 7.3 μM and shows good anti-respiratory syncytial virus (RSV) activity with an EC50 of 4.5 μM[1].
\r\nForsyshiyanine A (0.5-100 μg/mL) shows no significant cytotoxicity to MDCK cells with cell viability maintained above 80%[1].
\r\nForsyshiyanine A (50 μM) shows no significant cytotoxicity against five human tumor cell lines (A549 lung cancer, A2058 melanoma, HepG2 hepatoma, MCF-7 breast cancer, Mia PaCa-2 pancreatic cancer cells)[2].
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MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2767053-65-4
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Molecular Weight 259.39
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Formula C17H25NO
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SMILES
[H][C@@]12CCC3=NC(C)=CC=C3[C@]1(CCC[C@@]2(CO)C)C
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Zhao L, et al. Alkaloids bearing rare skeletons from Forsythia suspensa with anti-inflammatory and anti-viral activities in vitro. Phytochemistry. 2021;186:112739. [Content Brief]
[2]. Rfaish SY, et al. Semisynthesis of Forsyshiyanine A and a Derivative with Significant Anti-Pancreatic Cancer Activity. J Nat Prod. 2025;88(11):2781-2788. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Forsyshiyanine A Related Classifications
HY-N17236 Related Classifications
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