AKR1C3

By Targets:	17β-HSD (1) Aldose Reductase (4) DNA Alkylator/Crosslinker (1) Fluorescent Dye (1) Reactive Oxygen Species (1) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (21) Inflammation/Immunology (2) Neurological Disease (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-138557

AKR1C3-IN-4	17β-HSD	Cancer
AKR1C3-IN-4 is a potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitor with an IC₅₀ of 0.56 μM. AKR1C3-IN-4 has the potential for castrate resistant prostate cancer (CRPC) research .

HY-RS00536

AKR1C3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
AKR1C3 Human Pre-designed siRNA Set A contains three designed siRNAs for AKR1C3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

AKR1C3 Human Pre-designed siRNA Set A AKR1C3 Human Pre-designed siRNA Set A

HY-163323

AKR1C3-IN-12	Aldose Reductase	Cancer
AKR1C3-IN-12 (compound 2j) is an aldo-keto reductase 1C3 (AKR1C3) inhibitor with an IC₅₀ of 27 nM. AKR1C3-IN-12 enhances the efficacy of Gemcitabine and Cisplatin in bladder cancer .

HY-144749

AKR1C3-IN-5	Others	Cancer
AKR1C3-IN-5 (Compound 6e) is a potent inhibitor of *AKR1C3. AKR1C3* enzyme is overexpressed in hormone-dependent prostate and breast tumors. AKR1C3-IN-5 derived from drupanin, which exhibits half-maximal inhibitory concentration (IC₅₀) of 9.6 ± 3 μM and selectivity index (SI) of 5.5 against MCF-7 cells .

HY-146573

AKR1C3-IN-6	Others	Cancer
AKR1C3-IN-6 (Compound 1) is a potent, selective *AKR1C3* inhibitor with IC₅₀ values of 0.31 μM and 73.23 μM against AKR1C3 and AKR1C2, respectively. AKR1C3-IN-6 shows antitumor activity .

HY-146574

AKR1C3-IN-7

Others Cancer

AKR1C3-IN-7 (Compound 13) is a potent, selective AKR1C3 inhibitor with an IC₅₀ of 0.19 μM. AKR1C3-IN-7 shows antitumor activity .
HY-146575

AKR1C3-IN-8

Others Cancer

AKR1C3-IN-8 (Compound 5) is a potent, selective AKR1C3 inhibitor with an IC₅₀ of 0.069 μM. AKR1C3-IN-8 shows antitumor activity .
HY-107379

AKR1C3-IN-1

Others Others

AKR1C3-IN-1 is a potent, highly selective inhibitor of AKR1C3, with an IC₅₀ of 13 nM.

AKR1C3-IN-7	Others	Cancer
AKR1C3-IN-7 (Compound 13) is a potent, selective *AKR1C3* inhibitor with an IC₅₀ of 0.19 μM. AKR1C3-IN-7 shows antitumor activity .

AKR1C3-IN-8	Others	Cancer
AKR1C3-IN-8 (Compound 5) is a potent, selective *AKR1C3* inhibitor with an IC₅₀ of 0.069 μM. AKR1C3-IN-8 shows antitumor activity .

AKR1C3-IN-1	Others	Others
AKR1C3-IN-1 is a potent, highly selective inhibitor of *AKR1C3, with an IC₅₀* of 13 nM.

HY-157810

AKR1C3-IN-11	Aldose Reductase	Cancer
AKR1C3-IN-11 (Compound 6e) is a Aldo-keto reductase 1C3 (AKR1C3) inhibitor with an IC₅₀ of 2.0 μM. AKR1C3-IN-11 inhibit cell proliferation in combination with abiraterone (HY-70013). AKR1C3-IN-11 can be used for the research of prostate cancer .

HY-155502

AKR1C3-IN-10

Aldose Reductase Cancer

AKR1C3-IN-10 (compound 5r) is a selective AKR1C3 inhibitor (IC₅₀=51 nM). AKR1C3-IN-10 shows good activity in a prostate cancer xenograft model .

AKR1C3-IN-10	Aldose Reductase	Cancer
AKR1C3-IN-10 (compound 5r) is a selective *AKR1C3* inhibitor (IC₅₀=51 nM). AKR1C3-IN-10 shows good activity in a prostate cancer xenograft model .

HY-152188

AKR1C3-IN-9	Aldose Reductase	Cancer
AKR1C3-IN-9 is a selective inhibitor of Aldo-keto Reductase 1C3 (AKR1C3) with an IC₅₀ value of 8.92 nM. AKR1C3-IN-9 significantly reverses the Doxorubicin (HY-15142A) (DOX) resistance in a resistant breast cancer cell line .

HY-D1342

Coumberol

Fluorescent Dye Cancer

Coumberol is a fluorescent substrate of AKR1C3 protein. Coumberol can be used for the research of AKR1C3 .
HY-150646

S07-2009

Others Cancer

S07-2009 is a potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitor with an IC₅₀ value of 0.20 μM .

Coumberol	Fluorescent Dye	Cancer
Coumberol is a fluorescent substrate of AKR1C3 protein. Coumberol can be used for the research of AKR1C3 .

S07-2009	Others	Cancer
S07-2009 is a potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitor with an IC₅₀ value of 0.20 μM .

HY-150649

S07-2005 (racemic)	Others	Cancer
S07-2005 racemic is a potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitor with an IC₅₀ value of 0.13 μM and 0.75 μM for AKR1C3 and AKR1C4, respectively. S07-2005 racemic has potential as a chemotherapeutic potentiator for cancer agent resistance .

HY-19903

ASP-9521

1 Publications Verification

Others Cancer

ASP-9521 is a potent, selective and orally available AKR1C3 inhibitor with an IC₅₀ of 11 nM for human AKR1C3.

ASP-9521 1 Publications Verification	Others	Cancer
ASP-9521 is a potent, selective and orally available *AKR1C3* inhibitor with an IC₅₀ of 11 nM for human AKR1C3.

HY-155035

S07-1066	Others	Cancer
S07-1066 is an aldo-keto reductase 1C3 (AKR1C3) inhibitor, synergizing doxorubicin (DOX) cytotoxicity. S07-1066 selectively blocks AKR1C3-mediated reduction of DOX, and reverses the DOX resistance in overexpressing AKR1C3 cells .

HY-N10361

Drupanin	Others	Cancer
Drupanin is a compound isolated from green propolis. Drupanin can selectively inhibit the AKR1C3 enzyme. Drupanin has the potential for the research of breast cancer .

HY-109154

Obafistat

Others Inflammation/Immunology

Obafistat is a potent aldo-keto reductase AKR1C3 inhibitor with an IC₅₀ of 1.2 nM for human AKR1C3 (patent WO2017202817A1, example 4) .

Obafistat	Others	Inflammation/Immunology
Obafistat is a potent aldo-keto reductase *AKR1C3* inhibitor with an IC₅₀ of 1.2 nM for human AKR1C3 (patent WO2017202817A1, example 4) .

HY-152189

S19-1035	Others	Cancer
S19-1035 is a highly potent and specific aldo-keto reductase 1C3 (AKR1C3) inhibitor. S19-1035 inhibits AKR1C3 with an IC₅₀ value of 3.04 nM. S19-1035 can be used for the research of tumor .

HY-150648

S07-2008

Others Cancer

S07-2008 is a selective aldo-keto reductase family 1 member C3 (AKR1C3) inhibitor with an IC₅₀ of 0.16 μM. S07-2008 shows anticancer activities .

S07-2008	Others	Cancer
S07-2008 is a selective aldo-keto reductase family 1 member C3 (AKR1C3) inhibitor with an IC₅₀ of 0.16 μM. S07-2008 shows anticancer activities .

HY-124573

OBI-3424 TH-3424	DNA Alkylator/Crosslinker	Cancer
OBI-3424 (TH-3424) is a proagent that is selectively converted by AKR1C3 (aldo-keto reductase 1C3) to a potent DNA-alkylating agent. OBI-3424 can be used for hepatocellular carcinoma, castrate-resistant prostate cancer, and acute lymphoblastic leukemia (ALL) research .

HY-150650

S07-2001	Others	Cancer
S07-2001 is a potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitor with an IC₅₀ value of 2.08 μM. S07-2001 enhances the activity of Doxorubicin against cancer cells. S07-2001 has potential as a chemotherapeutic potentiator for cancer agent resistance .

HY-150644

S07-2010	Others	Cancer
S07-2010 is a potent pan-AKR1C (aldo-keto reductase family 1 member C) inhibitor, with IC₅₀ values of 0.19, 0.36, 0.47, and 0.73 μM for *AKR1C3, AKR1C4, AKR1C1* and AKR1C2, respectively. S07-2010 induces apoptosis in A549/DDP cells. S07-2010 strengthens the cytotoxicity of chemotherapeutic agents in drug-resistant cells. S07-2010 significantly inhibits the proliferation of drug-resistant cells .

HY-N0376

Liquiritin 5 Publications Verification	Reactive Oxygen Species	Neurological Disease Inflammation/Immunology Cancer
Liquiritin, a flavonoid isolated from Glycyrrhiza uralensis, is a potent and competitive AKR1C1 inhibitor with IC₅₀s of 0.62 μM, 0.61 μM, and 3.72μM for AKR1C1, AKR1C2 and AKR1C3, respectively. Liquiritin efficiently inhibits progesterone metabolism mediated by AKR1C1 in vivo . Liquiritin acts as an antioxidant and has neuroprotective, anti-cancer and anti-inflammatory activity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N10361

Drupanin	Monophenols Classification of Application Fields Animals Source classification Phenols Disease Research Fields Cancer	Others
Drupanin is a compound isolated from green propolis. Drupanin can selectively inhibit the AKR1C3 enzyme. Drupanin has the potential for the research of breast cancer .

HY-N0376

Liquiritin 5 Publications Verification	Structural Classification Neurological Disease Classification of Application Fields Source classification Plants Monophenols Flavonoids Leguminosae Flavonones Phenols Inflammation/Immunology Disease Research Fields Glycyrrhiza uralensis Fisch.	Reactive Oxygen Species
Liquiritin, a flavonoid isolated from Glycyrrhiza uralensis, is a potent and competitive AKR1C1 inhibitor with IC₅₀s of 0.62 μM, 0.61 μM, and 3.72μM for AKR1C1, AKR1C2 and AKR1C3, respectively. Liquiritin efficiently inhibits progesterone metabolism mediated by AKR1C1 in vivo . Liquiritin acts as an antioxidant and has neuroprotective, anti-cancer and anti-inflammatory activity .

Cat. No.	Compare	Product Name	Species	Source

HY-P7604

	AKR1C3 Protein, Human (HEK293, His) rHuAKR1C3, His; AKR1C3; HA1753; Dihydrodiol Dehydrogenase Type I; Indanol Dehydrogenase; Prostaglandin F Synthase	Human	HEK293
	AKR1C3 Protein, Human (HEK293, His) expresses in HEK293 cells with a His tag. Aldo-keto reductase family 1 member C3 (AKR1C3) is a steroidogenic enzyme that plays a crucial role in the conversion of adrenal androgen dehydroepiandrosterone (DHEA) into high-affinity ligands for the androgen receptor (testosterone [T] and dihydrotestosterone [DHT]).


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HY-P82593

AKR1C3 Antibody (YA2338)

DD3; DDX; HA1753; HAKRB; HAKRe; HSD17B5; KIAA0119; hluPGFS
WB, ICC/IF, IP, FC Human

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AKR1C3

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