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Cat. No.: HY-146573

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AKR1C3-IN-6

AKR1C3-IN-6 (Compound 1) is a potent, selective AKR1C3 inhibitor with IC₅₀ values of 0.31 μM and 73.23 μM against AKR1C3 and AKR1C2, respectively. AKR1C3-IN-6 shows antitumor activity.

For research use only. We do not sell to patients.

CAS No.: 2137881-54-8
Formula: C₁₈H₁₅F₃N₄O₃
Molecular Weight:392.33

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

AKR1C3-IN-6 Chemical Structure

CAS No.: 2137881-54-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

AKR1C3

0.31 μM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
CWR22R	IC₅₀	81.4 μM Compound: 1	Antiproliferative activity against human 22Rv1 cells after 72 hrs by sulforhodamine B colorimetric assay Antiproliferative activity against human 22Rv1 cells after 72 hrs by sulforhodamine B colorimetric assay	[PMID: 29602039]
CWR22R	IC₅₀	81.4 μM Compound: 1	Antiproliferative activity against human 22Rv1 cells expressing AKR1C3 assessed as inhibition of cell growth incubated for 72 hrs by SRB assay Antiproliferative activity against human 22Rv1 cells expressing AKR1C3 assessed as inhibition of cell growth incubated for 72 hrs by SRB assay	[PMID: 35447434]
CWR22R	IC₅₀	81.4 μM Compound: 8	Antiproliferative activity against human 22Rv1 cells after 72 hrs by sulforhodamine B colorimetric proliferation assay Antiproliferative activity against human 22Rv1 cells after 72 hrs by sulforhodamine B colorimetric proliferation assay	[PMID: 28881288]

In Vitro

AKR1C3-IN-6 (Compound 1) shows antiproliferative activity with an IC₅₀ of 81.40 ± 2.29 μM against prostate cancer cell line 22rv1^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2137881-54-8
Molecular Weight 392.33
Formula C₁₈H₁₅F₃N₄O₃
SMILES

COC1=CC=C(C=C1)CN2N=NC(O)=C2C(NC3=CC(C(F)(F)F)=CC=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Pippione AC, et al. New aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the hydroxytriazole scaffold. Eur J Med Chem. 2022 Jul 5;237:114366. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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