AKR1C3-IN-6
AKR1C3-IN-6 (Compound 1) is a potent, selective AKR1C3 inhibitor with IC50 values of 0.31 μM and 73.23 μM against AKR1C3 and AKR1C2, respectively. AKR1C3-IN-6 shows antitumor activity.
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- No. CAS: 2137881-54-8
- Fòrmula: C18H15F3N4O3
- Peso molecular:392.33
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Actividad biológica
Descripciòn
IC50 & Target
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AKR1C3 0.31 μM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CWR22R | IC50 |
81.4 μM
Compound: 1
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Antiproliferative activity against human 22Rv1 cells after 72 hrs by sulforhodamine B colorimetric assay
Antiproliferative activity against human 22Rv1 cells after 72 hrs by sulforhodamine B colorimetric assay
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[PMID: 29602039] |
| CWR22R | IC50 |
81.4 μM
Compound: 1
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Antiproliferative activity against human 22Rv1 cells expressing AKR1C3 assessed as inhibition of cell growth incubated for 72 hrs by SRB assay
Antiproliferative activity against human 22Rv1 cells expressing AKR1C3 assessed as inhibition of cell growth incubated for 72 hrs by SRB assay
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[PMID: 35447434] |
| CWR22R | IC50 |
81.4 μM
Compound: 8
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Antiproliferative activity against human 22Rv1 cells after 72 hrs by sulforhodamine B colorimetric proliferation assay
Antiproliferative activity against human 22Rv1 cells after 72 hrs by sulforhodamine B colorimetric proliferation assay
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[PMID: 28881288] |
In Vitro
AKR1C3-IN-6 (Compound 1) shows antiproliferative activity with an IC50 of 81.40 ± 2.29 μM against prostate cancer cell line 22rv1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 2137881-54-8
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Peso molecular 392.33
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Fòrmula C18H15F3N4O3
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SMILES
COC1=CC=C(C=C1)CN2N=NC(O)=C2C(NC3=CC(C(F)(F)F)=CC=C3)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AKR1C3-IN-6 Related Classifications
HY-146573 Related Classifications
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